L-seryl-tRNA(Sec) kinase - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

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Q58933 (PSTK_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 73. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
L-seryl-tRNA(Sec) kinase
EC=2.7.1.164

Alternative name(s):
O-phosphoseryl-tRNA(Sec) kinase
Short name=PSTK

Gene names

Name:	pstK
Ordered Locus Names:	MJ1538

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus ›

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis. Ref.2
Catalytic activity	ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec).
Pathway	Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 1/2.
Sequence similarities	Belongs to the L-seryl-tRNA(Sec) kinase family.
Sequence caution	The sequence AAB99557.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	selenocysteinyl-tRNA(Sec) biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activity Inferred from electronic annotation. Source: UniProtKB-KW phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 248

248

L-seryl-tRNA(Sec) kinase

PRO_0000107396

Regions

Nucleotide binding

7 – 14

ATP Potential

Secondary structure

248

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q58933 [UniParc].

Last modified May 1, 2007. Version 2.
Checksum: 815EF9A453BEA450
Show »

FASTA

248

29,467

        10         20         30         40         50         60 
MLIILTGLPG VGKSTFSKNL AKILSKNNID VIVLGSDLIR ESFPVWKEKY EEFIKKSTYR 

        70         80         90        100        110        120 
LIDSALKNYW VIVDDTNYYN SMRRDLINIA KKYNKNYAII YLKASLDVLI RRNIERGEKI 

       130        140        150        160        170        180 
PNEVIKKMYE KFDEPGKKYK WDEPFLIIDT TKDIDFNEIA KKLIEKSKEI PKFYVLEENK 

       190        200        210        220        230        240 
NKNNNISDKI DKETRKIVSE YIKSKKLDKD KIKEVVELRK EFLKKIKKME EVDADRVLKE 


FKDLLNSY

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. Venter J.C. Science 273:1058-1073(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
[2]	"Structural and functional investigation of a putative archaeal selenocysteine synthase." Kaiser J.T., Gromadski K., Rother M., Engelhardt H., Rodnina M.V., Wahl M.C. Biochemistry 44:13315-13327(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L77117 Genomic DNA. Translation: AAB99557.1. Different initiation.

PIR

A64492.

RefSeq

NP_248546.1. NC_000909.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3A4L	X-ray	1.80	A/B	1-248	[»]
3A4M	X-ray	1.79	A/B	1-248	[»]
3A4N	X-ray	2.50	A/B	1-248	[»]
3ADB	X-ray	2.80	A/B	1-248	[»]
3ADC	X-ray	2.90	A/B	1-248	[»]
3ADD	X-ray	2.40	A/B	1-248	[»]
3AM1	X-ray	2.40	A	1-248	[»]

ProteinModelPortal

Q58933.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-48971N.

STRING

243232.MJ1538.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAB99557; AAB99557; MJ_1538.

GeneID

1452446.

KEGG

mja:MJ_1538.

Phylogenomic databases

eggNOG

COG4088.

K10837.

OMA

VDDTNYY.

ProtClustDB

CLSK876615.

Enzyme and pathway databases

BioCyc

MetaCyc:MONOMER-14956.

UniPathway

UPA00906; UER00897.

Family and domain databases

InterPro

IPR013641. Chromatin_KTI12.
IPR020024. L-seryl-tRNA_Sec_kinase_arc.
[Graphical view]

Pfam

PF08433. KTI12. 1 hit.
[Graphical view]

TIGRFAMs

TIGR03574. selen_PSTK. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q58933.

Entry information

Entry name

PSTK_METJA

Accession

Primary (citable) accession number: Q58933

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	May 1, 2007
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Other

Entry information

Relevant documents