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Protein

Putative thioredoxin reductase

Gene

MJ1536

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.By similarity

Catalytic activityi

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39FADBy similarity8
Nucleotide bindingi272 – 280FADBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciMJAN243232:G1GKE-1664-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative thioredoxin reductase (EC:1.8.1.9)
Short name:
TRXR
Gene namesi
Ordered Locus Names:MJ1536
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001667591 – 301Putative thioredoxin reductaseAdd BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi130 ↔ 133Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi243232.MJ_1536

Structurei

3D structure databases

ProteinModelPortaliQ58931
SMRiQ58931
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiarCOG01296 Archaea
COG0492 LUCA
InParanoidiQ58931
KOiK00384
OMAiITHQIAN
OrthoDBiPOG093Z05W6
PhylomeDBiQ58931

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR008255 Pyr_nucl-diS_OxRdtase_2_AS
IPR000103 Pyridine_nuc-diS_OxRdtase_2
IPR005982 Thioredox_Rdtase
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PRINTSiPR00469 PNDRDTASEII
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01292 TRX_reduct, 1 hit
PROSITEiView protein in PROSITE
PS00573 PYRIDINE_REDOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q58931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHDTIIIGA GPGGLTAGIY AMRGKLNALC IEKENAGGRI AEAGIVENYP
60 70 80 90 100
GFEEIRGYEL AEKFKNHAEK FKLPIIYDEV IKIETKERPF KVITKNSEYL
110 120 130 140 150
TKTIVIATGT KPKKLGLNED KFIGRGISYC TMCDAFFYLN KEVIVIGRDT
160 170 180 190 200
PAIMSAINLK DIAKKVIVIT DKSELKAAES IMLDKLKEAN NVEIIYNAKP
210 220 230 240 250
LEIVGEERAE GVKISVNGKE EIIKADGIFI SLGHVPNTEF LKDSGIELDK
260 270 280 290 300
KGFIKTDENC RTNIDGIYAV GDVRGGVMQV AKAVGDGCVA MANIIKYLQK

L
Length:301
Mass (Da):33,035
Last modified:November 1, 1996 - v1
Checksum:iB8319F2B33559AD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB99556.1
PIRiG64491
RefSeqiWP_010871060.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB99556; AAB99556; MJ_1536
GeneIDi1452444
KEGGimja:MJ_1536

Similar proteinsi

Entry informationi

Entry nameiTRXB_METJA
AccessioniPrimary (citable) accession number: Q58931
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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