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Q58893

- MTM5_METJA

UniProt

Q58893 - MTM5_METJA

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Protein

Modification methylase MjaV

Gene
mjaVM, MJ1498
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

This methylase recognizes the double-stranded sequence GTAC, causes specific methylation on C-4 on both strands, and protects the DNA from cleavage by the MjaV endonuclease Reviewed prediction.

Catalytic activityi

S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N(4)-methylcytosine.

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. N-methyltransferase activity Source: InterPro
  3. site-specific DNA-methyltransferase (cytosine-N4-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3897. M.MjaV.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase MjaV (EC:2.1.1.113)
Short name:
M.MjaV
Alternative name(s):
N-4 cytosine-specific methyltransferase MjaV
Gene namesi
Name:mjaVM
Ordered Locus Names:MJ1498
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Modification methylase MjaVPRO_0000087938Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ1498.

Structurei

3D structure databases

ProteinModelPortaliQ58893.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0863.
OMAiHYKPINS.
PhylomeDBiQ58893.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002941. DNA_methylase_N4/N6.
IPR017985. MeTrfase_CN4_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00508. S21N4MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00093. N4_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58893-1 [UniParc]FASTAAdd to Basket

« Hide

MEINKIYCMD CLEGMKQLKD KTVDVVVTSP PYNIGIKYNK YSDNLSREDY    50
LNWIEEVVKE IKRVLKDDGS FFINVGYTAK DPWIAFDVAN VIRKHFKLQN 100
TIHWVKSIAI QKEDVGNYPN IIGDIAVGHY KPINSDRFLS IMHEYIFHFT 150
KNGNVKLDKL AIGVPYQDKS NIKRFNRKGD LRDRGNTWFI PYETIQSKEK 200
ERPHPATFPP KLPEMCIKLH GVKKTNLVLD PFMGIGSTAI ACIRLGIDYI 250
GFEIDEYYCR VAEERIKKEL LKTDGKFDNV KNKNIITLDA FI 292
Length:292
Mass (Da):33,877
Last modified:November 1, 1996 - v1
Checksum:iA5A46D7C8FBD3FE3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99509.1.
PIRiA64487.
RefSeqiNP_248505.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99509; AAB99509; MJ_1498.
GeneIDi1452405.
KEGGimja:MJ_1498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99509.1 .
PIRi A64487.
RefSeqi NP_248505.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58893.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ1498.

Protein family/group databases

REBASEi 3897. M.MjaV.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB99509 ; AAB99509 ; MJ_1498 .
GeneIDi 1452405.
KEGGi mja:MJ_1498.

Phylogenomic databases

eggNOGi COG0863.
OMAi HYKPINS.
PhylomeDBi Q58893.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR002941. DNA_methylase_N4/N6.
IPR017985. MeTrfase_CN4_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF01555. N6_N4_Mtase. 1 hit.
[Graphical view ]
PRINTSi PR00508. S21N4MTFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS00093. N4_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiMTM5_METJA
AccessioniPrimary (citable) accession number: Q58893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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