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Q58893 (MTM5_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Modification methylase MjaV

Short name=M.MjaV
EC=2.1.1.113
Alternative name(s):
N-4 cytosine-specific methyltransferase MjaV
Gene names
Name:mjaVM
Ordered Locus Names:MJ1498
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This methylase recognizes the double-stranded sequence GTAC, causes specific methylation on C-4 on both strands, and protects the DNA from cleavage by the MjaV endonuclease Potential.

Catalytic activity

S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N(4)-methylcytosine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Modification methylase MjaV
PRO_0000087938

Sequences

Sequence LengthMass (Da)Tools
Q58893 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A5A46D7C8FBD3FE3

FASTA29233,877
        10         20         30         40         50         60 
MEINKIYCMD CLEGMKQLKD KTVDVVVTSP PYNIGIKYNK YSDNLSREDY LNWIEEVVKE 

        70         80         90        100        110        120 
IKRVLKDDGS FFINVGYTAK DPWIAFDVAN VIRKHFKLQN TIHWVKSIAI QKEDVGNYPN 

       130        140        150        160        170        180 
IIGDIAVGHY KPINSDRFLS IMHEYIFHFT KNGNVKLDKL AIGVPYQDKS NIKRFNRKGD 

       190        200        210        220        230        240 
LRDRGNTWFI PYETIQSKEK ERPHPATFPP KLPEMCIKLH GVKKTNLVLD PFMGIGSTAI 

       250        260        270        280        290 
ACIRLGIDYI GFEIDEYYCR VAEERIKKEL LKTDGKFDNV KNKNIITLDA FI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB99509.1.
PIRA64487.
RefSeqNP_248505.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ58893.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ1498.

Protein family/group databases

REBASE3897. M.MjaV.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB99509; AAB99509; MJ_1498.
GeneID1452405.
KEGGmja:MJ_1498.

Phylogenomic databases

eggNOGCOG0863.
KOK00571.
K00590.
OMAHYKPINS.
PhylomeDBQ58893.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR002941. DNA_methylase_N4/N6.
IPR017985. MeTrfase_CN4_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSPR00508. S21N4MTFRASE.
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS00093. N4_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTM5_METJA
AccessionPrimary (citable) accession number: Q58893
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names