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Q58893

- MTM5_METJA

UniProt

Q58893 - MTM5_METJA

Protein

Modification methylase MjaV

Gene

mjaVM

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence GTAC, causes specific methylation on C-4 on both strands, and protects the DNA from cleavage by the MjaV endonuclease.Curated

    Catalytic activityi

    S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N(4)-methylcytosine.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (cytosine-N4-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3897. M.MjaV.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase MjaV (EC:2.1.1.113)
    Short name:
    M.MjaV
    Alternative name(s):
    N-4 cytosine-specific methyltransferase MjaV
    Gene namesi
    Name:mjaVM
    Ordered Locus Names:MJ1498
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Modification methylase MjaVPRO_0000087938Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243232.MJ1498.

    Structurei

    3D structure databases

    ProteinModelPortaliQ58893.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0863.
    OMAiHYKPINS.
    PhylomeDBiQ58893.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR002941. DNA_methylase_N4/N6.
    IPR017985. MeTrfase_CN4_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF01555. N6_N4_Mtase. 1 hit.
    [Graphical view]
    PRINTSiPR00508. S21N4MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00093. N4_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q58893-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEINKIYCMD CLEGMKQLKD KTVDVVVTSP PYNIGIKYNK YSDNLSREDY    50
    LNWIEEVVKE IKRVLKDDGS FFINVGYTAK DPWIAFDVAN VIRKHFKLQN 100
    TIHWVKSIAI QKEDVGNYPN IIGDIAVGHY KPINSDRFLS IMHEYIFHFT 150
    KNGNVKLDKL AIGVPYQDKS NIKRFNRKGD LRDRGNTWFI PYETIQSKEK 200
    ERPHPATFPP KLPEMCIKLH GVKKTNLVLD PFMGIGSTAI ACIRLGIDYI 250
    GFEIDEYYCR VAEERIKKEL LKTDGKFDNV KNKNIITLDA FI 292
    Length:292
    Mass (Da):33,877
    Last modified:November 1, 1996 - v1
    Checksum:iA5A46D7C8FBD3FE3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99509.1.
    PIRiA64487.
    RefSeqiNP_248505.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB99509; AAB99509; MJ_1498.
    GeneIDi1452405.
    KEGGimja:MJ_1498.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99509.1 .
    PIRi A64487.
    RefSeqi NP_248505.1. NC_000909.1.

    3D structure databases

    ProteinModelPortali Q58893.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ1498.

    Protein family/group databases

    REBASEi 3897. M.MjaV.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB99509 ; AAB99509 ; MJ_1498 .
    GeneIDi 1452405.
    KEGGi mja:MJ_1498.

    Phylogenomic databases

    eggNOGi COG0863.
    OMAi HYKPINS.
    PhylomeDBi Q58893.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR002941. DNA_methylase_N4/N6.
    IPR017985. MeTrfase_CN4_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF01555. N6_N4_Mtase. 1 hit.
    [Graphical view ]
    PRINTSi PR00508. S21N4MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS00093. N4_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
    2. Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiMTM5_METJA
    AccessioniPrimary (citable) accession number: Q58893
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3