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Q58860 (THRC_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Threonine synthase

Short name=TS
EC=4.2.3.1
Gene names
Name:thrC
Ordered Locus Names:MJ1465
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity.

Catalytic activity

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.

Sequence similarities

Belongs to the threonine synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   LigandPyridoxal phosphate
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionpyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

threonine synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 405405Threonine synthase
PRO_0000185642

Regions

Region233 – 2375Pyridoxal phosphate binding By similarity

Sites

Binding site1321Pyridoxal phosphate By similarity
Binding site3711Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue1061N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q58860 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: FAD055FB041E2DF0

FASTA40544,601
        10         20         30         40         50         60 
MLQRCIKCGK TYDVDEIIYT CECGGLLEII YDYEEIKDKV SEEKLRKREI GVWRYLEYLP 

        70         80         90        100        110        120 
VKDESKIVSL CEGGTPLYRC NNLEKELGIK ELYVKNEGAN PTGSFKDRGM TVGVTRANEL 

       130        140        150        160        170        180 
GVEVVGCAST GNTSASLAAY SARSGKKCIV LLPEGKVALG KLAQAMFYGA KVIQVKGNFD 

       190        200        210        220        230        240 
DALDMVKQLA KEKLIYLLNS INPFRLEGQK TIAFEICDQL NWQVPDRVIV PVGNAGNISA 

       250        260        270        280        290        300 
IWKGFKEFEI TGIIDELPKM TGIQADGAKP IVEAFRKRAK DIIPYKNPET IATAIRIGNP 

       310        320        330        340        350        360 
VNAPKALDAI YSSGGYAEAV TDEEIVEAQK LLARKEGIFV EPASASSIAG LKKLLEEGII 

       370        380        390        400 
DRDERIVCIT TGHGLKDPDA AIRASEEPIK IECDMNVLKR ILKEL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB99473.1.
PIRH64482.
RefSeqNP_248469.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ58860.
SMRQ58860. Positions 51-387.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ1465.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB99473; AAB99473; MJ_1465.
GeneID1452369.
KEGGmja:MJ_1465.

Phylogenomic databases

eggNOGCOG0498.
KOK01733.
OMAGITHMAM.
PhylomeDBQ58860.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-14634.
UniPathwayUPA00050; UER00065.

Family and domain databases

InterProIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR026260. Thr_Synthase_Gram_pos_bac.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamPF00291. PALP. 1 hit.
[Graphical view]
PIRSFPIRSF038945. Thr_synthase. 1 hit.
SUPFAMSSF53686. SSF53686. 1 hit.
TIGRFAMsTIGR00260. thrC. 1 hit.
PROSITEPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHRC_METJA
AccessionPrimary (citable) accession number: Q58860
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names