Reviewed, UniProtKB/Swiss-Prot Q58860 (THRC_METJA)

Names and origin

Protein names

Recommended name:
    Probable threonine synthase
      Short name=TS
    EC=4.2.3.1

Gene names

Name:	thrC
Ordered Locus Names:	MJ1465

Organism

Methanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP]

Taxonomic identifier

2190 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	O-phospho-L-homoserine + H2O = L-threonine + phosphate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.
Sequence similarities	Belongs to the serine/threonine dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro threonine synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 405	405	Probable threonine synthase		PRO_0000185642
Amino acid modifications
	Modified residue	106	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q58860-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: FAD055FB041E2DF0	FASTA	405	44,601
	10 20 30 40 50 60 MLQRCIKCGK TYDVDEIIYT CECGGLLEII YDYEEIKDKV SEEKLRKREI GVWRYLEYLP 70 80 90 100 110 120 VKDESKIVSL CEGGTPLYRC NNLEKELGIK ELYVKNEGAN PTGSFKDRGM TVGVTRANEL 130 140 150 160 170 180 GVEVVGCAST GNTSASLAAY SARSGKKCIV LLPEGKVALG KLAQAMFYGA KVIQVKGNFD 190 200 210 220 230 240 DALDMVKQLA KEKLIYLLNS INPFRLEGQK TIAFEICDQL NWQVPDRVIV PVGNAGNISA 250 260 270 280 290 300 IWKGFKEFEI TGIIDELPKM TGIQADGAKP IVEAFRKRAK DIIPYKNPET IATAIRIGNP 310 320 330 340 350 360 VNAPKALDAI YSSGGYAEAV TDEEIVEAQK LLARKEGIFV EPASASSIAG LKKLLEEGII 370 380 390 400 DRDERIVCIT TGHGLKDPDA AIRASEEPIK IECDMNVLKR ILKEL

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L77117 Genomic DNA. Translation: AAB99473.1.
PIR	H64482.
RefSeq	NP_248469.1.
3D structure databases
HSSP	HSSP built from PDB template 1E5X based on UniProtKB Q9S7B5.
ModBase	Search...
Genome annotation databases
GeneID	1452369.
GenomeReviews	Gene locus MJ1465 in contig L77117_GR.
KEGG	mja:MJ1465.
NMPDR	fig|243232.1.peg.1506.
TIGR	MJ1465.
Phylogenomic databases
HOGENOM	Q58860.
OMA	AIKIGNP.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_1465-MON.
BRENDA	4.2.3.1. 256362.
Family and domain databases
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. IPR004450. Thr_synthase. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
TIGRFAMs	TIGR00260. thrC. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THRC_METJA

Accession

Primary (citable) accession number: Q58860

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 3, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)