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Q58860

- THRC_METJA

UniProt

Q58860 - THRC_METJA

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Protein

Threonine synthase

Gene

thrC

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei132 – 1321Pyridoxal phosphateBy similarity
Binding sitei371 – 3711Pyridoxal phosphateBy similarity

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. threonine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14634.
UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:MJ1465
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Threonine synthasePRO_0000185642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei106 – 1061N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ1465.

Structurei

3D structure databases

ProteinModelPortaliQ58860.
SMRiQ58860. Positions 51-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni233 – 2375Pyridoxal phosphate bindingBy similarity

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiCOG0498.
InParanoidiQ58860.
KOiK01733.
OMAiGITHMAM.
PhylomeDBiQ58860.

Family and domain databases

InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR026260. Thr_Synthase_bac/arc.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF038945. Thr_synthase. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58860-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQRCIKCGK TYDVDEIIYT CECGGLLEII YDYEEIKDKV SEEKLRKREI
60 70 80 90 100
GVWRYLEYLP VKDESKIVSL CEGGTPLYRC NNLEKELGIK ELYVKNEGAN
110 120 130 140 150
PTGSFKDRGM TVGVTRANEL GVEVVGCAST GNTSASLAAY SARSGKKCIV
160 170 180 190 200
LLPEGKVALG KLAQAMFYGA KVIQVKGNFD DALDMVKQLA KEKLIYLLNS
210 220 230 240 250
INPFRLEGQK TIAFEICDQL NWQVPDRVIV PVGNAGNISA IWKGFKEFEI
260 270 280 290 300
TGIIDELPKM TGIQADGAKP IVEAFRKRAK DIIPYKNPET IATAIRIGNP
310 320 330 340 350
VNAPKALDAI YSSGGYAEAV TDEEIVEAQK LLARKEGIFV EPASASSIAG
360 370 380 390 400
LKKLLEEGII DRDERIVCIT TGHGLKDPDA AIRASEEPIK IECDMNVLKR

ILKEL
Length:405
Mass (Da):44,601
Last modified:November 1, 1996 - v1
Checksum:iFAD055FB041E2DF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99473.1.
PIRiH64482.
RefSeqiNP_248469.1. NC_000909.1.
WP_010870985.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99473; AAB99473; MJ_1465.
GeneIDi1452369.
KEGGimja:MJ_1465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99473.1 .
PIRi H64482.
RefSeqi NP_248469.1. NC_000909.1.
WP_010870985.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58860.
SMRi Q58860. Positions 51-387.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ1465.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB99473 ; AAB99473 ; MJ_1465 .
GeneIDi 1452369.
KEGGi mja:MJ_1465.

Phylogenomic databases

eggNOGi COG0498.
InParanoidi Q58860.
KOi K01733.
OMAi GITHMAM.
PhylomeDBi Q58860.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00065 .
BioCyci MetaCyc:MONOMER-14634.

Family and domain databases

InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR026260. Thr_Synthase_bac/arc.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
PIRSFi PIRSF038945. Thr_synthase. 1 hit.
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00260. thrC. 1 hit.
PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiTHRC_METJA
AccessioniPrimary (citable) accession number: Q58860
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3