Q58860 (THRC_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Threonine synthase
Short name=TS
EC=4.2.3.1

Gene names

Name:	thrC
Ordered Locus Names:	MJ1465

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity.
Catalytic activity	O-phospho-L-homoserine + H2O = L-threonine + phosphate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.
Sequence similarities	Belongs to the threonine synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro threonine synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 405	405	Threonine synthase		PRO_0000185642
Regions
	Region	233 – 237	5	Pyridoxal phosphate binding By similarity
Sites
	Binding site	132	1	Pyridoxal phosphate By similarity
	Binding site	371	1	Pyridoxal phosphate By similarity
Amino acid modifications
	Modified residue	106	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q58860 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: FAD055FB041E2DF0	FASTA	405	44,601
	10 20 30 40 50 60 MLQRCIKCGK TYDVDEIIYT CECGGLLEII YDYEEIKDKV SEEKLRKREI GVWRYLEYLP 70 80 90 100 110 120 VKDESKIVSL CEGGTPLYRC NNLEKELGIK ELYVKNEGAN PTGSFKDRGM TVGVTRANEL 130 140 150 160 170 180 GVEVVGCAST GNTSASLAAY SARSGKKCIV LLPEGKVALG KLAQAMFYGA KVIQVKGNFD 190 200 210 220 230 240 DALDMVKQLA KEKLIYLLNS INPFRLEGQK TIAFEICDQL NWQVPDRVIV PVGNAGNISA 250 260 270 280 290 300 IWKGFKEFEI TGIIDELPKM TGIQADGAKP IVEAFRKRAK DIIPYKNPET IATAIRIGNP 310 320 330 340 350 360 VNAPKALDAI YSSGGYAEAV TDEEIVEAQK LLARKEGIFV EPASASSIAG LKKLLEEGII 370 380 390 400 DRDERIVCIT TGHGLKDPDA AIRASEEPIK IECDMNVLKR ILKEL

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB99473.1.
PIR	H64482.
RefSeq	NP_248469.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q58860.
SMR	Q58860. Positions 51-387.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1452369.
GenomeReviews	Gene locus MJ1465 in contig L77117_GR.
KEGG	mja:MJ_1465.
NMPDR	fig|243232.1.peg.1506.
TIGR	MJ1465.
Phylogenomic databases
HOGENOM	HBG694883.
OMA	KAIMCAS.
ProtClustDB	PRK06260.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-14634. MJAN243232:MJ_1465-MONOMER.
Family and domain databases
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. IPR004450. Thr_synthase. [Graphical view]
KO	K01733.
Pfam	PF00291. PALP. 1 hit. [Graphical view]
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMs	TIGR00260. ThrC. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THRC_METJA

Accession

Primary (citable) accession number: Q58860

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program