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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei131NADBy similarity1
Binding sitei193NADBy similarity1
Binding sitei216NADBy similarity1
Binding sitei239SubstrateBy similarity1
Metal bindingi261ZincBy similarity1
Binding sitei261SubstrateBy similarity1
Metal bindingi264ZincBy similarity1
Binding sitei264SubstrateBy similarity1
Active sitei327Proton acceptorBy similarity1
Active sitei328Proton acceptorBy similarity1
Binding sitei328SubstrateBy similarity1
Metal bindingi361ZincBy similarity1
Binding sitei361SubstrateBy similarity1
Binding sitei415SubstrateBy similarity1
Metal bindingi420ZincBy similarity1
Binding sitei420SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:MJ1456
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001358941 – 429Histidinol dehydrogenaseAdd BLAST429

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_1456.

Structurei

3D structure databases

ProteinModelPortaliQ58851.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiarCOG04352. Archaea.
COG0141. LUCA.
InParanoidiQ58851.
KOiK00013.
OMAiGGTARFY.
PhylomeDBiQ58851.

Family and domain databases

CDDicd06572. Histidinol_dh. 1 hit.
HAMAPiMF_01024. HisD. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTGMIIKKI KELTKEEEEK IINRNKANFE EILPTVMEIL KDVKEKGDEA
60 70 80 90 100
LKYYTKKFDG VEIEDFKVTD EEIEEAYNSV DYKVVEAIER AKENIYFFHK
110 120 130 140 150
KQMEQIKDLN VENNGIILGQ VVRAIEKVGC YVPGGRAFYP STVLMTTIPA
160 170 180 190 200
KVAGCEEIYI TSPPTKDGKG NPATLIAGDI VGVSAIYKVG GVQAIGALAY
210 220 230 240 250
GTETIPKVDI IVGPGNIYVT TAKKMVYGEV AIDFLAGPSE VLIIADETAN
260 270 280 290 300
AEFVALDFIA QAEHDPNASC VITTTSEKKA EEIKNKIFEE IEKAERKEII
310 320 330 340 350
LKALENSAIL IGDLEECIEF SNKYAPEHLE ILTKNPEEVL NKIKHAGSVF
360 370 380 390 400
LGEYSPVPVG DYASGTNHVL PTSQFARMSS GLNVETFLKK ITYQKLDKES
410 420
LKNIADIVIT LAEAEGLFGH AEAVRRRLK
Length:429
Mass (Da):47,433
Last modified:November 1, 1996 - v1
Checksum:i5E4DF4B17699EDB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99465.1.
PIRiG64481.

Genome annotation databases

EnsemblBacteriaiAAB99465; AAB99465; MJ_1456.
KEGGimja:MJ_1456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99465.1.
PIRiG64481.

3D structure databases

ProteinModelPortaliQ58851.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1456.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99465; AAB99465; MJ_1456.
KEGGimja:MJ_1456.

Phylogenomic databases

eggNOGiarCOG04352. Archaea.
COG0141. LUCA.
InParanoidiQ58851.
KOiK00013.
OMAiGGTARFY.
PhylomeDBiQ58851.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Family and domain databases

CDDicd06572. Histidinol_dh. 1 hit.
HAMAPiMF_01024. HisD. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHISX_METJA
AccessioniPrimary (citable) accession number: Q58851
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.