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Protein

Type-2 restriction enzyme MjaII

Gene

mjaIIR

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Recognizes the double-stranded sequence GGNCC.

Catalytic activityi

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Restriction system

Protein family/group databases

REBASEi1222. MjaII.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 restriction enzyme MjaII (EC:3.1.21.4)
Short name:
R.MjaII
Alternative name(s):
Endonuclease MjaII
Type II restriction enzyme MjaII
Gene namesi
Name:mjaIIR
Ordered Locus Names:MJ1449
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Type-2 restriction enzyme MjaIIPRO_0000077333Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ1449.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG136805.
InParanoidiQ58844.
OMAiPNAGEMR.

Family and domain databases

InterProiIPR019045. Restrct_endonuc_II_TdeIII.
[Graphical view]
PfamiPF09520. RE_TdeIII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLSKNVIEK ISIETIRVLK SRFDTISDED IKIRNMPFHM AFLRAFYGKI
60 70 80 90 100
GINDDTEALK FLTLSQWFHG LSTTLGQSYF ENIAHILSNG EKRTFKNYKI
110 120 130 140 150
KRSVRDKISE IINDLKSGER LPNVEKENKE LREATSKNSE YVNGLEFTAD
160 170 180 190 200
VYFEDKDKVV MIELKTVRPN AGEMRGEKQK ILYGKAYMME TKPNKKVYYF
210 220 230 240 250
IGFPYDPTEN PENPCGYDKD RFMSSLIEFS KYFDKREVLI AEELWSFLSG
260 270 280 290 300
EENTMKKILD IINSIAKPDF KEKFDFINTF PFINQDRLYT KDAIDEQKFK
310 320 330 340 350
KYMDILQEWR LYSEIECAKA VKELSLLKLS SRDRRTFERL INNSMFSNNN
360 370
KYNENRKMKI LELYNKYMQK
Length:370
Mass (Da):43,911
Last modified:November 1, 1996 - v1
Checksum:i8B4CF6208F914B33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99461.1.
PIRiH64480.
RefSeqiNP_248453.1. NC_000909.1.
WP_010870969.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99461; AAB99461; MJ_1449.
GeneIDi1452353.
KEGGimja:MJ_1449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99461.1.
PIRiH64480.
RefSeqiNP_248453.1. NC_000909.1.
WP_010870969.1. NC_000909.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ1449.

Protein family/group databases

REBASEi1222. MjaII.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99461; AAB99461; MJ_1449.
GeneIDi1452353.
KEGGimja:MJ_1449.

Phylogenomic databases

eggNOGiNOG136805.
InParanoidiQ58844.
OMAiPNAGEMR.

Family and domain databases

InterProiIPR019045. Restrct_endonuc_II_TdeIII.
[Graphical view]
PfamiPF09520. RE_TdeIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiT2M2_METJA
AccessioniPrimary (citable) accession number: Q58844
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: March 4, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.