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Protein

Modification methylase MjaII

Gene

mjaIIM

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This methylase recognizes the double-stranded sequence GGNC, causes specific methylation on C-4 on both strands, and protects the DNA from cleavage by the MjaII endonuclease.Curated

Catalytic activityi

S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMJAN243232:G1GKE-1570-MONOMER

Protein family/group databases

REBASEi3896 M.MjaII

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase MjaII (EC:2.1.1.113)
Short name:
M.MjaII
Alternative name(s):
N-4 cytosine-specific methyltransferase MjaII
Gene namesi
Name:mjaIIM
Ordered Locus Names:MJ1448
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000879371 – 530Modification methylase MjaIIAdd BLAST530

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_1448

Structurei

3D structure databases

ProteinModelPortaliQ58843
SMRiQ58843
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00890 Archaea
COG0863 LUCA
InParanoidiQ58843
KOiK00590
OMAiHVHRLHP
OrthoDBiPOG093Z03XL
PhylomeDBiQ58843

Family and domain databases

InterProiView protein in InterPro
IPR002941 DNA_methylase_N4/N6
IPR017985 MeTrfase_CN4_CS
IPR001091 RM_Methylase
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF01555 N6_N4_Mtase, 2 hits
PRINTSiPR00508 S21N4MTFRASE
SUPFAMiSSF53335 SSF53335, 3 hits
PROSITEiView protein in PROSITE
PS00093 N4_MTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q58843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLDAWLDIQ PAKKLYTIKE ASRILTKKFG KEIKEHNISY LVQYGRVNKY
60 70 80 90 100
KIKNRVYVDI DEVENYYKKL FFEKRKEWEE KLGFKLDWDL AFDLLSEKER
110 120 130 140 150
TKHVHGIHPY KGKFIPQLVE YFLKRHFNVG DIIIDPFMGS GTTLVQCMEM
160 170 180 190 200
GINSIGIDIS PFNCLIAEVK LQKYDIQKLK KILLDMLNKT KEFSKNLGDD
210 220 230 240 250
EFVKEMDKLI EKYNKKYFTL EYKRKLSKKE IDEDSYSEKI MEMFYLEYKK
260 270 280 290 300
LKEKYCKNDD EFDDIFKDKP FLYKWYSPRI RAELNFYLNL IKDCRDETIK
310 320 330 340 350
KVAMIILSRT ARSVRGTTHF DLATLKEPVF DPYYCYKHKK ICRPVQTILR
360 370 380 390 400
HLEEYTNDVI SRIEEFSKIR KDAYYLIING DSRTVDIEEE LKKHPNFYEL
410 420 430 440 450
YKNKKIDGIF TSPPYLGQID YHEQHAYAYE LFDIPRLDEL EIGPKFKGSS
460 470 480 490 500
KKAQKEYIEG ISDVLINMKR FLNEDAKIFI VVNDKKNLYK EIFEKSGLIL
510 520 530
VREFKRPVLN RTERDRNPYY ESIFELKMEE
Length:530
Mass (Da):63,755
Last modified:November 1, 1996 - v1
Checksum:iFF6F29ADD080060C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB99457.1
PIRiG64480
RefSeqiWP_010870968.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB99457; AAB99457; MJ_1448
GeneIDi1452352
KEGGimja:MJ_1448

Similar proteinsi

Entry informationi

Entry nameiMTM2_METJA
AccessioniPrimary (citable) accession number: Q58843
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health