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Q58843

- MTM2_METJA

UniProt

Q58843 - MTM2_METJA

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Protein

Modification methylase MjaII

Gene

mjaIIM

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

This methylase recognizes the double-stranded sequence GGNC, causes specific methylation on C-4 on both strands, and protects the DNA from cleavage by the MjaII endonuclease.Curated

Catalytic activityi

S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N(4)-methylcytosine.

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. N-methyltransferase activity Source: InterPro
  3. site-specific DNA-methyltransferase (cytosine-N4-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3896. M.MjaII.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase MjaII (EC:2.1.1.113)
Short name:
M.MjaII
Alternative name(s):
N-4 cytosine-specific methyltransferase MjaII
Gene namesi
Name:mjaIIM
Ordered Locus Names:MJ1448
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Modification methylase MjaIIPRO_0000087937Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ1448.

Structurei

3D structure databases

ProteinModelPortaliQ58843.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0863.
InParanoidiQ58843.
OMAiIDYHEQH.
PhylomeDBiQ58843.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR002941. DNA_methylase_N4/N6.
IPR017985. MeTrfase_CN4_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF01555. N6_N4_Mtase. 2 hits.
[Graphical view]
PRINTSiPR00508. S21N4MTFRASE.
SUPFAMiSSF53335. SSF53335. 3 hits.
PROSITEiPS00093. N4_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58843-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLDAWLDIQ PAKKLYTIKE ASRILTKKFG KEIKEHNISY LVQYGRVNKY
60 70 80 90 100
KIKNRVYVDI DEVENYYKKL FFEKRKEWEE KLGFKLDWDL AFDLLSEKER
110 120 130 140 150
TKHVHGIHPY KGKFIPQLVE YFLKRHFNVG DIIIDPFMGS GTTLVQCMEM
160 170 180 190 200
GINSIGIDIS PFNCLIAEVK LQKYDIQKLK KILLDMLNKT KEFSKNLGDD
210 220 230 240 250
EFVKEMDKLI EKYNKKYFTL EYKRKLSKKE IDEDSYSEKI MEMFYLEYKK
260 270 280 290 300
LKEKYCKNDD EFDDIFKDKP FLYKWYSPRI RAELNFYLNL IKDCRDETIK
310 320 330 340 350
KVAMIILSRT ARSVRGTTHF DLATLKEPVF DPYYCYKHKK ICRPVQTILR
360 370 380 390 400
HLEEYTNDVI SRIEEFSKIR KDAYYLIING DSRTVDIEEE LKKHPNFYEL
410 420 430 440 450
YKNKKIDGIF TSPPYLGQID YHEQHAYAYE LFDIPRLDEL EIGPKFKGSS
460 470 480 490 500
KKAQKEYIEG ISDVLINMKR FLNEDAKIFI VVNDKKNLYK EIFEKSGLIL
510 520 530
VREFKRPVLN RTERDRNPYY ESIFELKMEE
Length:530
Mass (Da):63,755
Last modified:November 1, 1996 - v1
Checksum:iFF6F29ADD080060C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99457.1.
PIRiG64480.
RefSeqiNP_248452.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99457; AAB99457; MJ_1448.
GeneIDi1452352.
KEGGimja:MJ_1448.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99457.1 .
PIRi G64480.
RefSeqi NP_248452.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58843.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ1448.

Protein family/group databases

REBASEi 3896. M.MjaII.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB99457 ; AAB99457 ; MJ_1448 .
GeneIDi 1452352.
KEGGi mja:MJ_1448.

Phylogenomic databases

eggNOGi COG0863.
InParanoidi Q58843.
OMAi IDYHEQH.
PhylomeDBi Q58843.

Family and domain databases

Gene3Di 3.40.50.150. 2 hits.
InterProi IPR002941. DNA_methylase_N4/N6.
IPR017985. MeTrfase_CN4_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF01555. N6_N4_Mtase. 2 hits.
[Graphical view ]
PRINTSi PR00508. S21N4MTFRASE.
SUPFAMi SSF53335. SSF53335. 3 hits.
PROSITEi PS00093. N4_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiMTM2_METJA
AccessioniPrimary (citable) accession number: Q58843
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3