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Q58843 (MTM2_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Modification methylase MjaII

Short name=M.MjaII
EC=2.1.1.113
Alternative name(s):
N-4 cytosine-specific methyltransferase MjaII
Gene names
Name:mjaIIM
Ordered Locus Names:MJ1448
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This methylase recognizes the double-stranded sequence GGNC, causes specific methylation on C-4 on both strands, and protects the DNA from cleavage by the MjaII endonuclease Potential.

Catalytic activity

S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N(4)-methylcytosine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Modification methylase MjaII
PRO_0000087937

Sequences

Sequence LengthMass (Da)Tools
Q58843 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: FF6F29ADD080060C

FASTA53063,755
        10         20         30         40         50         60 
MNLDAWLDIQ PAKKLYTIKE ASRILTKKFG KEIKEHNISY LVQYGRVNKY KIKNRVYVDI 

        70         80         90        100        110        120 
DEVENYYKKL FFEKRKEWEE KLGFKLDWDL AFDLLSEKER TKHVHGIHPY KGKFIPQLVE 

       130        140        150        160        170        180 
YFLKRHFNVG DIIIDPFMGS GTTLVQCMEM GINSIGIDIS PFNCLIAEVK LQKYDIQKLK 

       190        200        210        220        230        240 
KILLDMLNKT KEFSKNLGDD EFVKEMDKLI EKYNKKYFTL EYKRKLSKKE IDEDSYSEKI 

       250        260        270        280        290        300 
MEMFYLEYKK LKEKYCKNDD EFDDIFKDKP FLYKWYSPRI RAELNFYLNL IKDCRDETIK 

       310        320        330        340        350        360 
KVAMIILSRT ARSVRGTTHF DLATLKEPVF DPYYCYKHKK ICRPVQTILR HLEEYTNDVI 

       370        380        390        400        410        420 
SRIEEFSKIR KDAYYLIING DSRTVDIEEE LKKHPNFYEL YKNKKIDGIF TSPPYLGQID 

       430        440        450        460        470        480 
YHEQHAYAYE LFDIPRLDEL EIGPKFKGSS KKAQKEYIEG ISDVLINMKR FLNEDAKIFI 

       490        500        510        520        530 
VVNDKKNLYK EIFEKSGLIL VREFKRPVLN RTERDRNPYY ESIFELKMEE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB99457.1.
PIRG64480.
RefSeqNP_248452.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ58843.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ1448.

Protein family/group databases

REBASE3896. M.MjaII.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB99457; AAB99457; MJ_1448.
GeneID1452352.
KEGGmja:MJ_1448.

Phylogenomic databases

eggNOGCOG0863.
KOK00590.
OMAIDYHEQH.
ProtClustDBCLSK796871.

Family and domain databases

InterProIPR002941. DNA_methylase_N4/N6.
IPR017985. MeTrfase_CN4_CS.
IPR001091. RM_Methylase.
[Graphical view]
PfamPF01555. N6_N4_Mtase. 2 hits.
[Graphical view]
PRINTSPR00508. S21N4MTFRASE.
PROSITEPS00093. N4_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTM2_METJA
AccessionPrimary (citable) accession number: Q58843
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names