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Q58843

- MTM2_METJA

UniProt

Q58843 - MTM2_METJA

Protein

Modification methylase MjaII

Gene

mjaIIM

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence GGNC, causes specific methylation on C-4 on both strands, and protects the DNA from cleavage by the MjaII endonuclease.Curated

    Catalytic activityi

    S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N(4)-methylcytosine.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (cytosine-N4-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3896. M.MjaII.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase MjaII (EC:2.1.1.113)
    Short name:
    M.MjaII
    Alternative name(s):
    N-4 cytosine-specific methyltransferase MjaII
    Gene namesi
    Name:mjaIIM
    Ordered Locus Names:MJ1448
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Modification methylase MjaIIPRO_0000087937Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243232.MJ1448.

    Structurei

    3D structure databases

    ProteinModelPortaliQ58843.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0863.
    OMAiIDYHEQH.
    PhylomeDBiQ58843.

    Family and domain databases

    Gene3Di3.40.50.150. 2 hits.
    InterProiIPR002941. DNA_methylase_N4/N6.
    IPR017985. MeTrfase_CN4_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF01555. N6_N4_Mtase. 2 hits.
    [Graphical view]
    PRINTSiPR00508. S21N4MTFRASE.
    SUPFAMiSSF53335. SSF53335. 3 hits.
    PROSITEiPS00093. N4_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q58843-1 [UniParc]FASTAAdd to Basket

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    MNLDAWLDIQ PAKKLYTIKE ASRILTKKFG KEIKEHNISY LVQYGRVNKY    50
    KIKNRVYVDI DEVENYYKKL FFEKRKEWEE KLGFKLDWDL AFDLLSEKER 100
    TKHVHGIHPY KGKFIPQLVE YFLKRHFNVG DIIIDPFMGS GTTLVQCMEM 150
    GINSIGIDIS PFNCLIAEVK LQKYDIQKLK KILLDMLNKT KEFSKNLGDD 200
    EFVKEMDKLI EKYNKKYFTL EYKRKLSKKE IDEDSYSEKI MEMFYLEYKK 250
    LKEKYCKNDD EFDDIFKDKP FLYKWYSPRI RAELNFYLNL IKDCRDETIK 300
    KVAMIILSRT ARSVRGTTHF DLATLKEPVF DPYYCYKHKK ICRPVQTILR 350
    HLEEYTNDVI SRIEEFSKIR KDAYYLIING DSRTVDIEEE LKKHPNFYEL 400
    YKNKKIDGIF TSPPYLGQID YHEQHAYAYE LFDIPRLDEL EIGPKFKGSS 450
    KKAQKEYIEG ISDVLINMKR FLNEDAKIFI VVNDKKNLYK EIFEKSGLIL 500
    VREFKRPVLN RTERDRNPYY ESIFELKMEE 530
    Length:530
    Mass (Da):63,755
    Last modified:November 1, 1996 - v1
    Checksum:iFF6F29ADD080060C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99457.1.
    PIRiG64480.
    RefSeqiNP_248452.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB99457; AAB99457; MJ_1448.
    GeneIDi1452352.
    KEGGimja:MJ_1448.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99457.1 .
    PIRi G64480.
    RefSeqi NP_248452.1. NC_000909.1.

    3D structure databases

    ProteinModelPortali Q58843.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ1448.

    Protein family/group databases

    REBASEi 3896. M.MjaII.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB99457 ; AAB99457 ; MJ_1448 .
    GeneIDi 1452352.
    KEGGi mja:MJ_1448.

    Phylogenomic databases

    eggNOGi COG0863.
    OMAi IDYHEQH.
    PhylomeDBi Q58843.

    Family and domain databases

    Gene3Di 3.40.50.150. 2 hits.
    InterProi IPR002941. DNA_methylase_N4/N6.
    IPR017985. MeTrfase_CN4_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF01555. N6_N4_Mtase. 2 hits.
    [Graphical view ]
    PRINTSi PR00508. S21N4MTFRASE.
    SUPFAMi SSF53335. SSF53335. 3 hits.
    PROSITEi PS00093. N4_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
    2. Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiMTM2_METJA
    AccessioniPrimary (citable) accession number: Q58843
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3