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Q58817

- RFCS_METJA

UniProt

Q58817 - RFCS_METJA

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Protein

Replication factor C small subunit

Gene
rfcS, MJ1422
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. endonuclease activity Source: InterPro
  3. four-way junction helicase activity Source: InterPro
  4. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. DNA recombination Source: InterPro
  2. DNA repair Source: InterPro
  3. DNA replication Source: UniProtKB-KW
  4. intein-mediated protein splicing Source: InterPro
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Replication factor C small subunit
Short name:
RFC small subunit
Alternative name(s):
Clamp loader small subunit
Cleaved into the following 3 chains:
Gene namesi
Name:rfcS
Ordered Locus Names:MJ1422
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5353Replication factor C small subunit, 1st part Reviewed predictionPRO_0000030361Add
BLAST
Chaini54 – 601548Mja RFC-1 intein Reviewed predictionPRO_0000030362Add
BLAST
Chaini602 – 62625Replication factor C small subunit, 2nd part Reviewed predictionPRO_0000030363Add
BLAST
Chaini627 – 1062436Mja RFC-2 intein Reviewed predictionPRO_0000030364Add
BLAST
Chaini1063 – 112462Replication factor C small subunit, 3rd part Reviewed predictionPRO_0000030365Add
BLAST
Chaini1125 – 1667543Mja RFC-3 intein Reviewed predictionPRO_0000030366Add
BLAST
Chaini1668 – 1847180Replication factor C small subunit, 4th part Reviewed predictionPRO_0000030367Add
BLAST

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation Reviewed prediction.

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Interactioni

Subunit structurei

Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL) By similarity.

Protein-protein interaction databases

STRINGi243232.MJ1422.

Structurei

3D structure databases

ProteinModelPortaliQ58817.
SMRiQ58817. Positions 2-53, 1058-1125, 1667-1847.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini179 – 311133DOD-type homing endonuclease 1Add
BLAST
Domaini780 – 927148DOD-type homing endonuclease 2Add
BLAST
Domaini1348 – 1508161DOD-type homing endonuclease 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1372.
KOiK04801.
OMAiTNDENEM.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
2.170.16.10. 7 hits.
3.10.28.10. 5 hits.
3.40.50.300. 4 hits.
InterProiIPR001387. Cro/C1-type_HTH.
IPR008824. DNA_helicase_Holl-junc_RuvB_N.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR027434. Homing_endonucl.
IPR006142. INTEIN.
IPR004042. Intein_endonuc.
IPR006141. Intein_splice_site.
IPR010982. Lambda_DNA-bd_dom.
IPR027417. P-loop_NTPase.
IPR013748. Rep_factorC_C_dom.
[Graphical view]
PfamiPF01381. HTH_3. 1 hit.
PF14528. LAGLIDADG_3. 3 hits.
PF08542. Rep_fac_C. 1 hit.
PF05496. RuvB_N. 1 hit.
[Graphical view]
PRINTSiPR00379. INTEIN.
SMARTiSM00305. HintC. 3 hits.
SM00306. HintN. 3 hits.
SM00530. HTH_XRE. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF48019. SSF48019. 1 hit.
SSF51294. SSF51294. 7 hits.
SSF52540. SSF52540. 3 hits.
SSF55608. SSF55608. 3 hits.
TIGRFAMsiTIGR01443. intein_Cterm. 3 hits.
TIGR01445. intein_Nterm. 3 hits.
PROSITEiPS50818. INTEIN_C_TER. 3 hits.
PS50819. INTEIN_ENDONUCLEASE. 3 hits.
PS50817. INTEIN_N_TER. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58817-1 [UniParc]FASTAAdd to Basket

« Hide

MVIIMEKPWV EKYRPKTLDD IVGQDEIVKR LKKYVEKKSM PHLLFSGPPG     50
VGKCLTGDTK VIVNGEIREI GEVIEEISNG KFGVTLTNNL KVLGIDEDGK 100
IREFDVQYVY KDKTNTLIKI KTKMGRELKV TTYHPLLINH KNGEIKWEKA 150
ENLKVGDKLA TPRYILFNES DYNEELAEWL GYFIGDGHAD KESNKITFTN 200
GDEKLRKRFA ELTEKLFKDA KIKERIHKDR TPDIYVNSKE AVEFIDKLGL 250
RGKKADKVRI PKEIMRSDAL RAFLRAYFDC DGGIEKHSIV LSTASKEMAE 300
DLVYALLRFG IIAKLREKVN KNNNKVYYHI VISNSSNLRT FLDNIGFSQE 350
RKLKKLLEII KDENPNLDVI TIDKEKIRYI RDRLKVKLTR DIEKDNWSYN 400
KCRKITQELL KEIYYRLEEL KEIEKALEEN ILIDWDEVAE RRKEIAEKTG 450
IRSDRILEYI RGKRKPSLKN YIKIANTLGK NIEKIIDAMR IFAKKYSSYA 500
EIGKMLNMWN SSIKIYLESN TQEIEKLEEI RKTELKLVKE ILNDEKLIDS 550
IGYVLFLASN EIYWDEIVEI EQLNGEFTIY DLHVPRYHNF IGGNLPTILH 600
NTTAALCLAR DLFGENWRDN FLELNASVSK DTPILVKIDG KVKRTTFEEL 650
DKIYFETNDE NEMYKKVDNL EVLTVDENFR VRWRKVSTII RHKVDKILRI 700
KFEGGYIELT GNHSIMMLDE NGLVAKKASD IKVGDCFLSF VANIEGEKDR 750
LDLKEFEPKD ITSRVKIIND FDIDEDTAWM LGLYVAEGAV GFKGKTSGQV 800
IYTLGSHEHD LINKLNDIVD KKGFSKYENF TGSGFDRKRL SAKQIRILNT 850
QLARFVEENF YDGNGRRARN KRIPDIIFEL KENLRVEFLK GLADGDSSGN 900
WREVVRISSK SDNLLIDTVW LARISGIESS IFENEARLIW KGGMKWKKSN 950
LLPAEPIIKM IKKLENKING NWRYILRHQL YEGKKRVSKD KIKQILEMVN 1000
VEKLSDKEKE VYDLLKKLSK TELYALVVKE IEIIDYNDFV YDVSVPNNEM 1050
FFAGNVPILL HNSDERGIDV IRTKVKDFAR TKPIGDVPFK IIFLDESDAL 1100
TADAQNALRR TMEKYSDVCR FILSCLTGDA KITLPDEREI KIEDFIKMFE 1150
ERKLKHVLNR NGEDLVLAGV KFNSKIVNHK VYRLVLESGR EIEATGDHKF 1200
LTRDGWKEVY ELKEDDEVLV YPALEGVGFE VDERRIIGLN EFYEFLTNYE 1250
IKLGYKPLGK AKSYKELITR DKEKILSRVL ELSDKYSKSE IRRKIEEEFG 1300
IKISLTTIKN LINGKIDGFA LKYVRKIKEL GWDEITYDDE KAGIFARLLG 1350
FIIGDGHLSK SKEGRILITA TINELEGIKK DLEKLGIKAS NIIEKDIEHK 1400
LDGREIKGKT SFIYINNKAF YLLLNFWGVE IGNKTINGYN IPKWIKYGNK 1450
FVKREFLRGL FGADGTKPYI KKYNINGIKL GIRVENISKD KTLEFFEEVK 1500
KMLEEFEVES YIKVSKIDNK NLTELIVKAN NKNYLKYLSR ISYAYEKDNF 1550
ARLVGEYLRI KEAYKDIILK EIAENALKEA DGEKSLRELA RKYNVPVDFI 1600
INQLKGKDIG LPRNFMTFEE FLKEKVVDGK YVSERIIKKE CIGYRDVYDI 1650
TCHKDPSFIA NGFVSHNCNY PSKIIPPIQS RCAVFRFSPL KKEDIAKKLK 1700
EIAEKEGLNL TESGLEAIIY VSEGDMRKAI NVLQTAAALS DVIDDEIVYK 1750
VSSRARPEEV KKMMELALDG KFMEARDLLY KLMVEWGMSG EDILNQMFRE 1800
INSLDIDERK KVELADAIGE TDFRIVEGAN ERIQLSALLA KMALMGR 1847
Length:1,847
Mass (Da):214,097
Last modified:November 1, 1996 - v1
Checksum:i44EADB5B4D6DE64A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99433.1.
PIRiE64477.
RefSeqiNP_248426.1. NC_000909.1.
WP_010870940.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99433; AAB99433; MJ_1422.
GeneIDi1452326.
KEGGimja:MJ_1422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99433.1 .
PIRi E64477.
RefSeqi NP_248426.1. NC_000909.1.
WP_010870940.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58817.
SMRi Q58817. Positions 2-53, 1058-1125, 1667-1847.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ1422.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB99433 ; AAB99433 ; MJ_1422 .
GeneIDi 1452326.
KEGGi mja:MJ_1422.

Phylogenomic databases

eggNOGi COG1372.
KOi K04801.
OMAi TNDENEM.

Family and domain databases

Gene3Di 1.10.260.40. 1 hit.
2.170.16.10. 7 hits.
3.10.28.10. 5 hits.
3.40.50.300. 4 hits.
InterProi IPR001387. Cro/C1-type_HTH.
IPR008824. DNA_helicase_Holl-junc_RuvB_N.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR027434. Homing_endonucl.
IPR006142. INTEIN.
IPR004042. Intein_endonuc.
IPR006141. Intein_splice_site.
IPR010982. Lambda_DNA-bd_dom.
IPR027417. P-loop_NTPase.
IPR013748. Rep_factorC_C_dom.
[Graphical view ]
Pfami PF01381. HTH_3. 1 hit.
PF14528. LAGLIDADG_3. 3 hits.
PF08542. Rep_fac_C. 1 hit.
PF05496. RuvB_N. 1 hit.
[Graphical view ]
PRINTSi PR00379. INTEIN.
SMARTi SM00305. HintC. 3 hits.
SM00306. HintN. 3 hits.
SM00530. HTH_XRE. 1 hit.
[Graphical view ]
SUPFAMi SSF47413. SSF47413. 1 hit.
SSF48019. SSF48019. 1 hit.
SSF51294. SSF51294. 7 hits.
SSF52540. SSF52540. 3 hits.
SSF55608. SSF55608. 3 hits.
TIGRFAMsi TIGR01443. intein_Cterm. 3 hits.
TIGR01445. intein_Nterm. 3 hits.
PROSITEi PS50818. INTEIN_C_TER. 3 hits.
PS50819. INTEIN_ENDONUCLEASE. 3 hits.
PS50817. INTEIN_N_TER. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiRFCS_METJA
AccessioniPrimary (citable) accession number: Q58817
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The intein interrupts the potential ATP-binding site.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Intein-containing proteins
    List of intein-containing protein entries
  2. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3