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Q58813

- FUCA_METJA

UniProt

Q58813 - FUCA_METJA

Protein

L-fuculose phosphate aldolase

Gene

fucA

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible aldol cleavage of L-fuculose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. The substrate preference order is glyceraldehyde > DL-lactaldehyde, glycolaldehyde > acrolein > formaldehyde, methylglyoxal > acetaldehyde > crotonaldehyde. No activity was observed towards propionaldehyde.1 Publication

    Catalytic activityi

    L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.1 Publication

    Cofactori

    Binds 1 zinc ion per subunit.Curated

    Kineticsi

      Vmax=570 nmol/min/mg enzyme with glyceraldehyde as substrate (at pH 7.4 and at 70 degrees Celsius)1 Publication

      Vmax=501 nmol/min/mg enzyme with DL-lactaldehyde as substrate (at pH 7.4 and at 70 degrees Celsius)1 Publication

      Pathwayi

      Sites

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Metal bindingi68 – 681ZincBy similarity
      Metal bindingi87 – 871ZincBy similarity
      Metal bindingi89 – 891ZincBy similarity
      Metal bindingi147 – 1471ZincBy similarity

      GO - Molecular functioni

      1. L-fuculose-phosphate aldolase activity Source: UniProtKB-EC
      2. metal ion binding Source: UniProtKB-KW

      GO - Biological processi

      1. fucose catabolic process Source: UniProtKB-UniPathway

      Keywords - Molecular functioni

      Lyase

      Keywords - Ligandi

      Metal-binding, Zinc

      Enzyme and pathway databases

      BioCyciMetaCyc:MONOMER-12176.
      UniPathwayiUPA00071.
      UPA00563; UER00626.

      Names & Taxonomyi

      Protein namesi
      Recommended name:
      L-fuculose phosphate aldolase (EC:4.1.2.17)
      Alternative name(s):
      L-fuculose-1-phosphate aldolase
      Gene namesi
      Name:fucA
      Ordered Locus Names:MJ1418
      OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
      Taxonomic identifieri243232 [NCBI]
      Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
      ProteomesiUP000000805: Chromosome

      PTM / Processingi

      Molecule processing

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Chaini1 – 181181L-fuculose phosphate aldolasePRO_0000162932Add
      BLAST

      Interactioni

      Subunit structurei

      Homotetramer.1 Publication

      Protein-protein interaction databases

      STRINGi243232.MJ1418.

      Structurei

      3D structure databases

      ProteinModelPortaliQ58813.
      ModBaseiSearch...
      MobiDBiSearch...

      Family & Domainsi

      Sequence similaritiesi

      Phylogenomic databases

      eggNOGiCOG0235.
      KOiK01628.
      OMAiEANGIVH.
      PhylomeDBiQ58813.

      Family and domain databases

      Gene3Di3.40.225.10. 1 hit.
      InterProiIPR001303. Aldolase_II/adducin_N.
      [Graphical view]
      PfamiPF00596. Aldolase_II. 1 hit.
      [Graphical view]
      SMARTiSM01007. Aldolase_II. 1 hit.
      [Graphical view]
      SUPFAMiSSF53639. SSF53639. 1 hit.

      Sequencei

      Sequence statusi: Complete.

      Q58813-1 [UniParc]FASTAAdd to Basket

      « Hide

      MDKKQFIKIC RKLYDRKYVV GSGGNVSVKE GDKIYLTPTG SILGFLKEDD    50
      IAEMDLDGNV IKGKPTSEKN LHLMIYRKRN DINAIIHTHS LISTFLSTIN 100
      KEIELLTPEG KIFLKKIGYV DYYEAGSLKL AEETAKRDED VIILKNHGVV 150
      CLGKDLIDAY IKVEVLEEQA KLTLLNLLVK K 181
      Length:181
      Mass (Da):20,470
      Last modified:November 1, 1996 - v1
      Checksum:iE5F3BF13722145B0
      GO

      Sequence databases

      Select the link destinations:
      EMBL
      GenBank
      DDBJ
      Links Updated
      L77117 Genomic DNA. Translation: AAB99428.1.
      PIRiA64477.
      RefSeqiNP_248422.1. NC_000909.1.
      WP_010870936.1. NC_000909.1.

      Genome annotation databases

      EnsemblBacteriaiAAB99428; AAB99428; MJ_1418.
      GeneIDi1452322.
      KEGGimja:MJ_1418.

      Cross-referencesi

      Sequence databases

      Select the link destinations:
      EMBL
      GenBank
      DDBJ
      Links Updated
      L77117 Genomic DNA. Translation: AAB99428.1 .
      PIRi A64477.
      RefSeqi NP_248422.1. NC_000909.1.
      WP_010870936.1. NC_000909.1.

      3D structure databases

      ProteinModelPortali Q58813.
      ModBasei Search...
      MobiDBi Search...

      Protein-protein interaction databases

      STRINGi 243232.MJ1418.

      Protocols and materials databases

      Structural Biology Knowledgebase Search...

      Genome annotation databases

      EnsemblBacteriai AAB99428 ; AAB99428 ; MJ_1418 .
      GeneIDi 1452322.
      KEGGi mja:MJ_1418.

      Phylogenomic databases

      eggNOGi COG0235.
      KOi K01628.
      OMAi EANGIVH.
      PhylomeDBi Q58813.

      Enzyme and pathway databases

      UniPathwayi UPA00071 .
      UPA00563 ; UER00626 .
      BioCyci MetaCyc:MONOMER-12176.

      Family and domain databases

      Gene3Di 3.40.225.10. 1 hit.
      InterProi IPR001303. Aldolase_II/adducin_N.
      [Graphical view ]
      Pfami PF00596. Aldolase_II. 1 hit.
      [Graphical view ]
      SMARTi SM01007. Aldolase_II. 1 hit.
      [Graphical view ]
      SUPFAMi SSF53639. SSF53639. 1 hit.
      ProtoNeti Search...

      Publicationsi

      1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
        Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
      2. "Identification of lactaldehyde dehydrogenase in Methanocaldococcus jannaschii and its involvement in production of lactate for F420 biosynthesis."
        Grochowski L.L., Xu H., White R.H.
        J. Bacteriol. 188:2836-2844(2006) [PubMed] [Europe PMC] [Abstract]
        Cited for: FUNCTION IN F420 BIOSYNTHESIS, CATALYTIC ACTIVITY, SUBUNIT, BIOPHYSICOCHEMICAL PROPERTIES.

      Entry informationi

      Entry nameiFUCA_METJA
      AccessioniPrimary (citable) accession number: Q58813
      Entry historyi
      Integrated into UniProtKB/Swiss-Prot: November 1, 1997
      Last sequence update: November 1, 1996
      Last modified: October 1, 2014
      This is version 84 of the entry and version 1 of the sequence. [Complete history]
      Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programProkaryotic Protein Annotation Program

      Miscellaneousi

      Keywords - Technical termi

      Complete proteome, Reference proteome

      Documents

      1. Methanococcus jannaschii
        Methanococcus jannaschii: entries and gene names
      2. PATHWAY comments
        Index of metabolic and biosynthesis pathways
      3. SIMILARITY comments
        Index of protein domains and families

      External Data

      Dasty 3