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Protein

Archaeal Lon protease

Gene

MJ1417

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei5501 Publication1
Active sitei5931 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi47 – 54ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiS16.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Archaeal Lon protease (EC:3.4.21.-)
Alternative name(s):
ATP-dependent protease La homolog
Gene namesi
Ordered Locus Names:MJ1417
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 114CytoplasmicSequence analysisAdd BLAST114
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 138ExtracellularSequence analysis3
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 649CytoplasmicSequence analysisAdd BLAST490

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761501 – 649Archaeal Lon proteaseAdd BLAST649

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity (By similarity).By similarity

Protein-protein interaction databases

STRINGi243232.MJ_1417.

Structurei

Secondary structure

1649
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi461 – 466Combined sources6
Beta strandi469 – 472Combined sources4
Beta strandi475 – 485Combined sources11
Beta strandi490 – 496Combined sources7
Helixi498 – 517Combined sources20
Beta strandi533 – 541Combined sources9
Turni545 – 547Combined sources3
Helixi548 – 551Combined sources4
Helixi552 – 564Combined sources13
Beta strandi570 – 574Combined sources5
Beta strandi583 – 585Combined sources3
Helixi590 – 599Combined sources10
Beta strandi603 – 608Combined sources6
Helixi609 – 614Combined sources6
Beta strandi620 – 628Combined sources9
Helixi629 – 636Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XHKX-ray1.90A/B456-640[»]
ProteinModelPortaliQ58812.
SMRiQ58812.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58812.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini456 – 639Lon proteolyticPROSITE-ProRule annotationAdd BLAST184

Sequence similaritiesi

Contains 1 Lon proteolytic domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG02160. Archaea.
COG1067. LUCA.
InParanoidiQ58812.
KOiK04076.
OMAiDVHIQFV.
PhylomeDBiQ58812.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR004663. Lon_arc.
IPR027065. Lon_Prtase.
IPR000523. Mg_chelatse_chII_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 2 hits.
PfamiPF05362. Lon_C. 1 hit.
PF01078. Mg_chelatase. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR00764. lon_rel. 1 hit.
PROSITEiPS51786. LON_PROTEOLYTIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSIKFKTTE ELPEPSPRLI DQVIGQEEAV KIVLSAVKNK RNVILLGDPG
60 70 80 90 100
VGKSMIVKAV GEILSDFGEF TPYYVIAKPN LKNMERPIVE VIDGEYKEDS
110 120 130 140 150
KDMPKLDFKA PSSTTLLLIM IGAILLSEYL LKYLPQNYLL AAVTITALIV
160 170 180 190 200
LIFGFVIILT SIMGASRASM PNNLNPMDLK PVLLYECKKR PLVRASAYNV
210 220 230 240 250
TRLLGDIKHC PLGGRPPLGT PPHKRIILGA IHEAHRGILY VDEIKTMPLE
260 270 280 290 300
VQDYILTALQ DKQLPISGRN PNSSGATVET NPIPCDFILI MSGNMDDVYN
310 320 330 340 350
LRAPLLDRID YKIVLKNKMD NTLENRDKLL QFIVQEIKNN NLNPMTYDGC
360 370 380 390 400
CEVVRIAQYL AGSKDKLTLR LRLLANIIKM ANDVAMGKDV EELLGNFDDK
410 420 430 440 450
GEYHPETQKD KSNKVYITAE HVRKVFDTGI YSMEKQVALN YIKNFKRYKH
460 470 480 490 500
IVPNDEPKVG VIYGLAVLGA GGIGDVTKII VQILESKNPG THLLNISGDI
510 520 530 540 550
AKHSITLASA LSKKLVAEKK LPLPKKDIDL NNKEIYIQFS QSYSKIDGDS
560 570 580 590 600
ATAAVCLAII SALLDIPLKQ DFAITGSLDL SGNVLAIGGV NEKIEAAKRY
610 620 630 640
GFKRVIIPEA NMIDVIETEG IEIIPVKTLD EIVPLVFDLD NRGGAERFN
Length:649
Mass (Da):71,918
Last modified:November 1, 1996 - v1
Checksum:i2419207160114DBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99427.1.
PIRiH64476.
RefSeqiWP_010870934.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99427; AAB99427; MJ_1417.
GeneIDi1452320.
KEGGimja:MJ_1417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99427.1.
PIRiH64476.
RefSeqiWP_010870934.1. NC_000909.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XHKX-ray1.90A/B456-640[»]
ProteinModelPortaliQ58812.
SMRiQ58812.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1417.

Protein family/group databases

MEROPSiS16.008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99427; AAB99427; MJ_1417.
GeneIDi1452320.
KEGGimja:MJ_1417.

Phylogenomic databases

eggNOGiarCOG02160. Archaea.
COG1067. LUCA.
InParanoidiQ58812.
KOiK04076.
OMAiDVHIQFV.
PhylomeDBiQ58812.

Miscellaneous databases

EvolutionaryTraceiQ58812.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR004663. Lon_arc.
IPR027065. Lon_Prtase.
IPR000523. Mg_chelatse_chII_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 2 hits.
PfamiPF05362. Lon_C. 1 hit.
PF01078. Mg_chelatase. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR00764. lon_rel. 1 hit.
PROSITEiPS51786. LON_PROTEOLYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLONB_METJA
AccessioniPrimary (citable) accession number: Q58812
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.