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Protein

Archaeal Lon protease

Gene

MJ1417

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei5501 Publication1
Active sitei5931 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi47 – 54ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMJAN243232:G1GKE-1535-MONOMER

Protein family/group databases

MEROPSiS16.008

Names & Taxonomyi

Protein namesi
Recommended name:
Archaeal Lon protease (EC:3.4.21.-)
Alternative name(s):
ATP-dependent protease La homolog
Gene namesi
Ordered Locus Names:MJ1417
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 114CytoplasmicSequence analysisAdd BLAST114
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 138ExtracellularSequence analysis3
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 649CytoplasmicSequence analysisAdd BLAST490

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761501 – 649Archaeal Lon proteaseAdd BLAST649

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity (By similarity).By similarity

Protein-protein interaction databases

STRINGi243232.MJ_1417

Structurei

Secondary structure

1649
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi461 – 466Combined sources6
Beta strandi469 – 472Combined sources4
Beta strandi475 – 485Combined sources11
Beta strandi490 – 496Combined sources7
Helixi498 – 517Combined sources20
Beta strandi533 – 541Combined sources9
Turni545 – 547Combined sources3
Helixi548 – 551Combined sources4
Helixi552 – 564Combined sources13
Beta strandi570 – 574Combined sources5
Beta strandi583 – 585Combined sources3
Helixi590 – 599Combined sources10
Beta strandi603 – 608Combined sources6
Helixi609 – 614Combined sources6
Beta strandi620 – 628Combined sources9
Helixi629 – 636Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XHKX-ray1.90A/B456-640[»]
ProteinModelPortaliQ58812
SMRiQ58812
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58812

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini456 – 639Lon proteolyticPROSITE-ProRule annotationAdd BLAST184

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG02160 Archaea
COG1067 LUCA
InParanoidiQ58812
KOiK04076
OMAiGLYFWNL
OrthoDBiPOG093Z00OX
PhylomeDBiQ58812

Family and domain databases

Gene3Di3.30.230.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR004663 Lon_arc
IPR008269 Lon_proteolytic
IPR027065 Lon_Prtase
IPR000523 Mg_chelatse_chII_dom
IPR027417 P-loop_NTPase
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10046 PTHR10046, 1 hit
PfamiView protein in Pfam
PF05362 Lon_C, 1 hit
PF01078 Mg_chelatase, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF54211 SSF54211, 1 hit
TIGRFAMsiTIGR00764 lon_rel, 1 hit
PROSITEiView protein in PROSITE
PS51786 LON_PROTEOLYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

Q58812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSIKFKTTE ELPEPSPRLI DQVIGQEEAV KIVLSAVKNK RNVILLGDPG
60 70 80 90 100
VGKSMIVKAV GEILSDFGEF TPYYVIAKPN LKNMERPIVE VIDGEYKEDS
110 120 130 140 150
KDMPKLDFKA PSSTTLLLIM IGAILLSEYL LKYLPQNYLL AAVTITALIV
160 170 180 190 200
LIFGFVIILT SIMGASRASM PNNLNPMDLK PVLLYECKKR PLVRASAYNV
210 220 230 240 250
TRLLGDIKHC PLGGRPPLGT PPHKRIILGA IHEAHRGILY VDEIKTMPLE
260 270 280 290 300
VQDYILTALQ DKQLPISGRN PNSSGATVET NPIPCDFILI MSGNMDDVYN
310 320 330 340 350
LRAPLLDRID YKIVLKNKMD NTLENRDKLL QFIVQEIKNN NLNPMTYDGC
360 370 380 390 400
CEVVRIAQYL AGSKDKLTLR LRLLANIIKM ANDVAMGKDV EELLGNFDDK
410 420 430 440 450
GEYHPETQKD KSNKVYITAE HVRKVFDTGI YSMEKQVALN YIKNFKRYKH
460 470 480 490 500
IVPNDEPKVG VIYGLAVLGA GGIGDVTKII VQILESKNPG THLLNISGDI
510 520 530 540 550
AKHSITLASA LSKKLVAEKK LPLPKKDIDL NNKEIYIQFS QSYSKIDGDS
560 570 580 590 600
ATAAVCLAII SALLDIPLKQ DFAITGSLDL SGNVLAIGGV NEKIEAAKRY
610 620 630 640
GFKRVIIPEA NMIDVIETEG IEIIPVKTLD EIVPLVFDLD NRGGAERFN
Length:649
Mass (Da):71,918
Last modified:November 1, 1996 - v1
Checksum:i2419207160114DBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB99427.1
PIRiH64476
RefSeqiWP_010870934.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB99427; AAB99427; MJ_1417
GeneIDi1452320
KEGGimja:MJ_1417

Similar proteinsi

Entry informationi

Entry nameiLONB_METJA
AccessioniPrimary (citable) accession number: Q58812
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health