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Protein

Archaeal Lon protease

Gene

MJ1417

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei550 – 55011 Publication
Active sitei593 – 59311 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi47 – 548ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiS16.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Archaeal Lon protease (EC:3.4.21.-)
Alternative name(s):
ATP-dependent protease La homolog
Gene namesi
Ordered Locus Names:MJ1417
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 114114CytoplasmicSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Topological domaini136 – 1383ExtracellularSequence analysis
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST
Topological domaini160 – 649490CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 649649Archaeal Lon proteasePRO_0000076150Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity (By similarity).By similarity

Protein-protein interaction databases

STRINGi243232.MJ_1417.

Structurei

Secondary structure

1
649
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi461 – 4666Combined sources
Beta strandi469 – 4724Combined sources
Beta strandi475 – 48511Combined sources
Beta strandi490 – 4967Combined sources
Helixi498 – 51720Combined sources
Beta strandi533 – 5419Combined sources
Turni545 – 5473Combined sources
Helixi548 – 5514Combined sources
Helixi552 – 56413Combined sources
Beta strandi570 – 5745Combined sources
Beta strandi583 – 5853Combined sources
Helixi590 – 59910Combined sources
Beta strandi603 – 6086Combined sources
Helixi609 – 6146Combined sources
Beta strandi620 – 6289Combined sources
Helixi629 – 6368Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XHKX-ray1.90A/B456-640[»]
ProteinModelPortaliQ58812.
SMRiQ58812. Positions 456-640.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58812.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini456 – 639184Lon proteolyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Lon proteolytic domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG02160. Archaea.
COG1067. LUCA.
InParanoidiQ58812.
KOiK04076.
OMAiDVHIQFV.
PhylomeDBiQ58812.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR004663. Lon_arc.
IPR027065. Lon_Prtase.
IPR000523. Mg_chelatse_chII_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 2 hits.
PfamiPF05362. Lon_C. 1 hit.
PF01078. Mg_chelatase. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR00764. lon_rel. 1 hit.
PROSITEiPS51786. LON_PROTEOLYTIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSIKFKTTE ELPEPSPRLI DQVIGQEEAV KIVLSAVKNK RNVILLGDPG
60 70 80 90 100
VGKSMIVKAV GEILSDFGEF TPYYVIAKPN LKNMERPIVE VIDGEYKEDS
110 120 130 140 150
KDMPKLDFKA PSSTTLLLIM IGAILLSEYL LKYLPQNYLL AAVTITALIV
160 170 180 190 200
LIFGFVIILT SIMGASRASM PNNLNPMDLK PVLLYECKKR PLVRASAYNV
210 220 230 240 250
TRLLGDIKHC PLGGRPPLGT PPHKRIILGA IHEAHRGILY VDEIKTMPLE
260 270 280 290 300
VQDYILTALQ DKQLPISGRN PNSSGATVET NPIPCDFILI MSGNMDDVYN
310 320 330 340 350
LRAPLLDRID YKIVLKNKMD NTLENRDKLL QFIVQEIKNN NLNPMTYDGC
360 370 380 390 400
CEVVRIAQYL AGSKDKLTLR LRLLANIIKM ANDVAMGKDV EELLGNFDDK
410 420 430 440 450
GEYHPETQKD KSNKVYITAE HVRKVFDTGI YSMEKQVALN YIKNFKRYKH
460 470 480 490 500
IVPNDEPKVG VIYGLAVLGA GGIGDVTKII VQILESKNPG THLLNISGDI
510 520 530 540 550
AKHSITLASA LSKKLVAEKK LPLPKKDIDL NNKEIYIQFS QSYSKIDGDS
560 570 580 590 600
ATAAVCLAII SALLDIPLKQ DFAITGSLDL SGNVLAIGGV NEKIEAAKRY
610 620 630 640
GFKRVIIPEA NMIDVIETEG IEIIPVKTLD EIVPLVFDLD NRGGAERFN
Length:649
Mass (Da):71,918
Last modified:November 1, 1996 - v1
Checksum:i2419207160114DBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99427.1.
PIRiH64476.

Genome annotation databases

EnsemblBacteriaiAAB99427; AAB99427; MJ_1417.
KEGGimja:MJ_1417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99427.1.
PIRiH64476.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XHKX-ray1.90A/B456-640[»]
ProteinModelPortaliQ58812.
SMRiQ58812. Positions 456-640.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1417.

Protein family/group databases

MEROPSiS16.008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99427; AAB99427; MJ_1417.
KEGGimja:MJ_1417.

Phylogenomic databases

eggNOGiarCOG02160. Archaea.
COG1067. LUCA.
InParanoidiQ58812.
KOiK04076.
OMAiDVHIQFV.
PhylomeDBiQ58812.

Miscellaneous databases

EvolutionaryTraceiQ58812.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR004663. Lon_arc.
IPR027065. Lon_Prtase.
IPR000523. Mg_chelatse_chII_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 2 hits.
PfamiPF05362. Lon_C. 1 hit.
PF01078. Mg_chelatase. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR00764. lon_rel. 1 hit.
PROSITEiPS51786. LON_PROTEOLYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLONB_METJA
AccessioniPrimary (citable) accession number: Q58812
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: February 17, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.