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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:MJ1415
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367231 – 370Tryptophan--tRNA ligaseAdd BLAST370

Proteomic databases

PRIDEiQ58810

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_1415

Structurei

3D structure databases

ProteinModelPortaliQ58810
SMRiQ58810
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi75 – 83"HIGH" region9
Motifi255 – 259"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
InParanoidiQ58810
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z044X
PhylomeDBiQ58810

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q58810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLMELTPWE TPAVIDYKKT MEQFGVKPIV DVLGDLKEEH HFFRRNIILG
60 70 80 90 100
HRDFERIVDA IKNNKEFAVV SGMMPSGKMH FGHKMVVDLL KFYQKYTDNI
110 120 130 140 150
NIPIADLEAY WARNMSFETT KELALNEYIT NYIALGLDPE KINVYLQSKY
160 170 180 190 200
QKVKDLALIL SKRTNWSEMK AIYGFKGETN IGHVFAPIVQ VADILHPQLD
210 220 230 240 250
ENLSPEPKPV VVPVGIDQDP HIRLTRDIAN RAKEFKFIPP SSTYHRFMTG
260 270 280 290 300
LLGGKMSSSK PETAIFLTDD EKTVKKKIFS AKTGGRETLE EHKKYGGVPE
310 320 330 340 350
ECVVYELFLY HLILDDKELA EIYQKCRSGE LTCGKCKKMA YERVVEFLKD
360 370
LKEKREQAKE IAVKILEGKY
Length:370
Mass (Da):42,661
Last modified:November 1, 1997 - v1
Checksum:iE6C71107CF82B59D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB99425.1
PIRiF64476

Genome annotation databases

EnsemblBacteriaiAAB99425; AAB99425; MJ_1415
KEGGimja:MJ_1415

Similar proteinsi

Entry informationi

Entry nameiSYW_METJA
AccessioniPrimary (citable) accession number: Q58810
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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