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Protein

Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)

Gene

uppS

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei57UniRule annotation1
Metal bindingi57MagnesiumUniRule annotation1
Binding sitei70SubstrateUniRule annotation1
Binding sitei74SubstrateUniRule annotation1
Active sitei105Proton acceptorUniRule annotation1
Binding sitei106SubstrateUniRule annotation1
Binding sitei108SubstrateUniRule annotation1
Binding sitei229SubstrateUniRule annotation1
Metal bindingi248MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)UniRule annotation (EC:2.5.1.89UniRule annotation)
Alternative name(s):
Undecaprenyl diphosphate synthaseUniRule annotation
Short name:
UDSUniRule annotation
Undecaprenyl pyrophosphate synthaseUniRule annotation
Short name:
UPP synthaseUniRule annotation
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:MJ1372
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001237311 – 280Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)Add BLAST280

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243232.MJ_1372.

Structurei

3D structure databases

ProteinModelPortaliQ58767.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni58 – 61Substrate bindingUniRule annotation4
Regioni102 – 104Substrate bindingUniRule annotation3
Regioni235 – 237Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
InParanoidiQ58767.
KOiK15888.
OMAiWAKLKNK.
PhylomeDBiQ58767.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58767-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGILGKIKNK LKSIGKRVII DFYRFLDNSG VLKIYEKILE EAIDKDNLPK
60 70 80 90 100
HVAIIMDGNR RAAEIYGKDR YYGHYLGAEK VREVLRWARD LGINVVTLYA
110 120 130 140 150
FSTENFRRPK EEVDKLMELF EKKFYEIADD EEIHRYEVRV RAIGRINLLP
160 170 180 190 200
KNVQKAIKYA EERTKNYNKF FVNIAIAYGG QQEIIDAVKK IAEKVKRGEI
210 220 230 240 250
EPEDIDKELI DKHLYTANLP FPNPDLIIRT SGEERISNFL IWQSSYSELY
260 270 280
FCDIYWPLFR RVDFLRAVRD YQRRQRRFGK
Length:280
Mass (Da):33,286
Last modified:November 1, 1997 - v1
Checksum:iFCB6C9FF5C65CC76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99380.1.
PIRiC64471.

Genome annotation databases

EnsemblBacteriaiAAB99380; AAB99380; MJ_1372.
KEGGimja:MJ_1372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99380.1.
PIRiC64471.

3D structure databases

ProteinModelPortaliQ58767.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1372.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99380; AAB99380; MJ_1372.
KEGGimja:MJ_1372.

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
InParanoidiQ58767.
KOiK15888.
OMAiWAKLKNK.
PhylomeDBiQ58767.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUPPS_METJA
AccessioniPrimary (citable) accession number: Q58767
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.