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Q58690 (FUMA_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative fumarate hydratase subunit alpha

Short name=Fumarase
EC=4.2.1.2
Gene names
Ordered Locus Names:MJ1294
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-malate = fumarate + H2O.

Cofactor

Iron-sulfur.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Sequence similarities

Belongs to the class-I fumarase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Ligand4Fe-4S
Iron
Iron-sulfur
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_function4 iron, 4 sulfur cluster binding

Inferred from electronic annotation. Source: UniProtKB-KW

fumarate hydratase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Putative fumarate hydratase subunit alpha
PRO_0000195661

Sites

Metal binding601Iron-sulfur By similarity
Metal binding1821Iron-sulfur By similarity
Metal binding2691Iron-sulfur By similarity

Sequences

Sequence LengthMass (Da)Tools
Q58690 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 49BA64703BBC7ABC

FASTA28531,088
        10         20         30         40         50         60 
MKISDVVVEL FREAAIYLPE DVKNALEEAY KKESSEISKN TLKAIIENNK IAEETQVPLC 

        70         80         90        100        110        120 
QDTGVPIVFL KIGKNINSSE IMKIIEEIKE GVKKATEEVP LRPNVVHPLT RENFKTNVGL 

       130        140        150        160        170        180 
NSPFINIEFD ESLDREIEII AFPKGAGSEN MSALKMLKPS DGIEGIKNFV LETIANAGGK 

       190        200        210        220        230        240 
PCPPIVVGIG IGGTADVALK LAKKALLRKI GERHRDKEIA NLEKELLEKI NSLGIGAMGL 

       250        260        270        280 
GGDITALDVF IEIAGCHTAS LPVGICIQCW ADRRAIKRIK LDAKL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB99301.1.
PIRE64461.
RefSeqNP_248294.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ58690.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ1294.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB99301; AAB99301; MJ_1294.
GeneID1452196.
KEGGmja:MJ_1294.

Phylogenomic databases

eggNOGCOG1951.
KOK01677.
OMAETYPTHI.
ProtClustDBPRK06246.

Enzyme and pathway databases

UniPathwayUPA00223; UER01007.

Family and domain databases

InterProIPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
[Graphical view]
PfamPF05681. Fumerase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00722. ttdA_fumA_fumB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFUMA_METJA
AccessionPrimary (citable) accession number: Q58690
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names