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Q58690

- FUMA_METJA

UniProt

Q58690 - FUMA_METJA

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Protein
Putative fumarate hydratase subunit alpha
Gene
MJ1294
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate = fumarate + H2O.

Cofactori

Iron-sulfur.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron-sulfur By similarity
Metal bindingi182 – 1821Iron-sulfur By similarity
Metal bindingi269 – 2691Iron-sulfur By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. fumarate hydratase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01007.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fumarate hydratase subunit alpha (EC:4.2.1.2)
Short name:
Fumarase
Gene namesi
Ordered Locus Names:MJ1294
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Putative fumarate hydratase subunit alpha
PRO_0000195661Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ1294.

Structurei

3D structure databases

ProteinModelPortaliQ58690.

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I fumarase family.

Phylogenomic databases

eggNOGiCOG1951.
KOiK01677.
OMAiVNIQCWA.
PhylomeDBiQ58690.

Family and domain databases

InterProiIPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
[Graphical view]
PfamiPF05681. Fumerase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00722. ttdA_fumA_fumB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58690-1 [UniParc]FASTAAdd to Basket

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MKISDVVVEL FREAAIYLPE DVKNALEEAY KKESSEISKN TLKAIIENNK    50
IAEETQVPLC QDTGVPIVFL KIGKNINSSE IMKIIEEIKE GVKKATEEVP 100
LRPNVVHPLT RENFKTNVGL NSPFINIEFD ESLDREIEII AFPKGAGSEN 150
MSALKMLKPS DGIEGIKNFV LETIANAGGK PCPPIVVGIG IGGTADVALK 200
LAKKALLRKI GERHRDKEIA NLEKELLEKI NSLGIGAMGL GGDITALDVF 250
IEIAGCHTAS LPVGICIQCW ADRRAIKRIK LDAKL 285
Length:285
Mass (Da):31,088
Last modified:November 1, 1996 - v1
Checksum:i49BA64703BBC7ABC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99301.1.
PIRiE64461.
RefSeqiNP_248294.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99301; AAB99301; MJ_1294.
GeneIDi1452196.
KEGGimja:MJ_1294.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99301.1 .
PIRi E64461.
RefSeqi NP_248294.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58690.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ1294.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB99301 ; AAB99301 ; MJ_1294 .
GeneIDi 1452196.
KEGGi mja:MJ_1294.

Phylogenomic databases

eggNOGi COG1951.
KOi K01677.
OMAi VNIQCWA.
PhylomeDBi Q58690.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01007 .

Family and domain databases

InterProi IPR004646. Fe-S_hydro-lyase_TtdA-typ_cat.
[Graphical view ]
Pfami PF05681. Fumerase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00722. ttdA_fumA_fumB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiFUMA_METJA
AccessioniPrimary (citable) accession number: Q58690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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