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Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 258GTPBy similarity
Nucleotide bindingi90 – 945GTPBy similarity
Nucleotide bindingi146 – 1494GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit gamma
Alternative name(s):
aIF2-gamma
eIF-2-gamma
Gene namesi
Name:eif2g
Ordered Locus Names:MJ1261
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Translation initiation factor 2 subunit gammaPRO_0000137454Add
BLAST

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.By similarity

Protein-protein interaction databases

STRINGi243232.MJ_1261.

Structurei

Secondary structure

1
411
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi12 – 187Combined sources
Helixi24 – 329Combined sources
Beta strandi52 – 609Combined sources
Turni62 – 643Combined sources
Beta strandi67 – 726Combined sources
Beta strandi81 – 9010Combined sources
Helixi94 – 1029Combined sources
Beta strandi109 – 1168Combined sources
Helixi124 – 13512Combined sources
Beta strandi141 – 1466Combined sources
Turni153 – 1586Combined sources
Helixi159 – 1679Combined sources
Turni171 – 1744Combined sources
Beta strandi177 – 1793Combined sources
Helixi188 – 19811Combined sources
Beta strandi211 – 2188Combined sources
Helixi227 – 2293Combined sources
Beta strandi234 – 2429Combined sources
Beta strandi249 – 25810Combined sources
Beta strandi265 – 2728Combined sources
Beta strandi275 – 2784Combined sources
Beta strandi281 – 2866Combined sources
Beta strandi288 – 2903Combined sources
Beta strandi292 – 2954Combined sources
Helixi300 – 3023Combined sources
Helixi304 – 3063Combined sources
Turni307 – 3104Combined sources
Beta strandi312 – 3154Combined sources
Beta strandi322 – 33211Combined sources
Beta strandi353 – 3586Combined sources
Beta strandi361 – 37111Combined sources
Beta strandi374 – 38411Combined sources
Beta strandi390 – 3967Combined sources
Beta strandi398 – 41114Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S0UX-ray2.40A9-411[»]
ProteinModelPortaliQ58657.
SMRiQ58657. Positions 9-411.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58657.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 203195tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni18 – 258G1By similarity
Regioni46 – 505G2By similarity
Regioni90 – 934G3By similarity
Regioni146 – 1494G4By similarity
Regioni181 – 1833G5By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
InParanoidiQ58657.
KOiK03242.
OMAiIAANEPC.
PhylomeDBiQ58657.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKKQAKQA EVNIGMVGHV DHGKTSLTKA LTGVWTDRHS EELRRGISIR
60 70 80 90 100
LGYADCEIRK CPQCGTYTTK PRCPNCLAET EFLRRVSFVD SPGHETLMAT
110 120 130 140 150
MLSGASLMDG AILVIAANEP CPQPQTKEHL MALEILGIDK IIIVQNKIDL
160 170 180 190 200
VDEKQAEENY EQIKEFVKGT IAENAPIIPI SAHHEANIDV LLKAIQDFIP
210 220 230 240 250
TPKRDPDATP RMYVARSFDI NKPGTEIKDL KGGVLGGAII QGVFKVGDEI
260 270 280 290 300
EIRPGIKVTE GNKTFWKPLT TKIVSLAAGN TILRKAHPGG LIGVGTTLDP
310 320 330 340 350
YLTKSDALTG SVVGLPGTLP PIREKITIRA NLLDRVVGTK EELKIEPLRT
360 370 380 390 400
GEVLMLNIGT ATTAGVITSA RGDIADIKLK LPICAEIGDR VAISRRVGSR
410
WRLIGYGTIE G
Length:411
Mass (Da):44,596
Last modified:June 21, 2005 - v2
Checksum:i75D94AF71088008F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99264.1.
PIRiD64457.

Genome annotation databases

EnsemblBacteriaiAAB99264; AAB99264; MJ_1261.
KEGGimja:MJ_1261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99264.1.
PIRiD64457.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S0UX-ray2.40A9-411[»]
ProteinModelPortaliQ58657.
SMRiQ58657. Positions 9-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1261.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99264; AAB99264; MJ_1261.
KEGGimja:MJ_1261.

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
InParanoidiQ58657.
KOiK03242.
OMAiIAANEPC.
PhylomeDBiQ58657.

Miscellaneous databases

EvolutionaryTraceiQ58657.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. "X-ray structure of translation initiation factor eIF2gamma: implications for tRNA and eIF2alpha binding."
    Roll-Mecak A., Alone P., Cao C., Dever T.E., Burley S.K.
    J. Biol. Chem. 279:10634-10642(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 9-411.

Entry informationi

Entry nameiIF2G_METJA
AccessioniPrimary (citable) accession number: Q58657
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 21, 2005
Last modified: February 17, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.