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Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25GTPBy similarity8
Nucleotide bindingi90 – 94GTPBy similarity5
Nucleotide bindingi146 – 149GTPBy similarity4

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMJAN243232:G1GKE-1369-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit gamma
Alternative name(s):
aIF2-gamma
eIF-2-gamma
Gene namesi
Name:eif2g
Ordered Locus Names:MJ1261
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001374541 – 411Translation initiation factor 2 subunit gammaAdd BLAST411

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.By similarity

Protein-protein interaction databases

STRINGi243232.MJ_1261

Structurei

Secondary structure

1411
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 18Combined sources7
Helixi24 – 32Combined sources9
Beta strandi52 – 60Combined sources9
Turni62 – 64Combined sources3
Beta strandi67 – 72Combined sources6
Beta strandi81 – 90Combined sources10
Helixi94 – 102Combined sources9
Beta strandi109 – 116Combined sources8
Helixi124 – 135Combined sources12
Beta strandi141 – 146Combined sources6
Turni153 – 158Combined sources6
Helixi159 – 167Combined sources9
Turni171 – 174Combined sources4
Beta strandi177 – 179Combined sources3
Helixi188 – 198Combined sources11
Beta strandi211 – 218Combined sources8
Helixi227 – 229Combined sources3
Beta strandi234 – 242Combined sources9
Beta strandi249 – 258Combined sources10
Beta strandi265 – 272Combined sources8
Beta strandi275 – 278Combined sources4
Beta strandi281 – 286Combined sources6
Beta strandi288 – 290Combined sources3
Beta strandi292 – 295Combined sources4
Helixi300 – 302Combined sources3
Helixi304 – 306Combined sources3
Turni307 – 310Combined sources4
Beta strandi312 – 315Combined sources4
Beta strandi322 – 332Combined sources11
Beta strandi353 – 358Combined sources6
Beta strandi361 – 371Combined sources11
Beta strandi374 – 384Combined sources11
Beta strandi390 – 396Combined sources7
Beta strandi398 – 411Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S0UX-ray2.40A9-411[»]
ProteinModelPortaliQ58657
SMRiQ58657
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58657

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 203tr-type GAdd BLAST195

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni18 – 25G1By similarity8
Regioni46 – 50G2By similarity5
Regioni90 – 93G3By similarity4
Regioni146 – 149G4By similarity4
Regioni181 – 183G5By similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01563 Archaea
COG5257 LUCA
InParanoidiQ58657
KOiK03242
OMAiCPQPQTK
OrthoDBiPOG093Z03P8
PhylomeDBiQ58657

Family and domain databases

CDDicd15490 eIF2_gamma_III, 1 hit
HAMAPiMF_00119 eIF_2_gamma, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR022424 TIF2_gsu
IPR015256 TIF2_gsu_C
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
PfamiView protein in Pfam
PF09173 eIF2_C, 1 hit
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03680 eif2g_arch, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q58657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKKQAKQA EVNIGMVGHV DHGKTSLTKA LTGVWTDRHS EELRRGISIR
60 70 80 90 100
LGYADCEIRK CPQCGTYTTK PRCPNCLAET EFLRRVSFVD SPGHETLMAT
110 120 130 140 150
MLSGASLMDG AILVIAANEP CPQPQTKEHL MALEILGIDK IIIVQNKIDL
160 170 180 190 200
VDEKQAEENY EQIKEFVKGT IAENAPIIPI SAHHEANIDV LLKAIQDFIP
210 220 230 240 250
TPKRDPDATP RMYVARSFDI NKPGTEIKDL KGGVLGGAII QGVFKVGDEI
260 270 280 290 300
EIRPGIKVTE GNKTFWKPLT TKIVSLAAGN TILRKAHPGG LIGVGTTLDP
310 320 330 340 350
YLTKSDALTG SVVGLPGTLP PIREKITIRA NLLDRVVGTK EELKIEPLRT
360 370 380 390 400
GEVLMLNIGT ATTAGVITSA RGDIADIKLK LPICAEIGDR VAISRRVGSR
410
WRLIGYGTIE G
Length:411
Mass (Da):44,596
Last modified:June 21, 2005 - v2
Checksum:i75D94AF71088008F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB99264.1
PIRiD64457
RefSeqiWP_064496772.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB99264; AAB99264; MJ_1261
GeneIDi1452159
KEGGimja:MJ_1261

Similar proteinsi

Entry informationi

Entry nameiIF2G_METJA
AccessioniPrimary (citable) accession number: Q58657
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 21, 2005
Last modified: March 28, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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