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Protein

3-hexulose-6-phosphate isomerase

Gene

phi

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the isomerization between 3-hexulose 6-phosphate and fructose 6-phosphate.1 Publication

Catalytic activityi

D-arabino-hex-3-ulose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: D-ribose 5-phosphate biosynthesis

This protein is involved in the pathway D-ribose 5-phosphate biosynthesis, which is part of Carbohydrate biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in the pathway D-ribose 5-phosphate biosynthesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511SubstrateCurated
Active sitei147 – 1471Proton acceptorCurated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BRENDAi5.3.1.27. 3260.
UniPathwayiUPA00293.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hexulose-6-phosphate isomerase (EC:5.3.1.27)
Alternative name(s):
6-phospho-3-hexuloisomerase
Short name:
PHI
Gene namesi
Name:phi
Ordered Locus Names:MJ1247
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1801803-hexulose-6-phosphate isomerasePRO_0000136568Add
BLAST

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi243232.MJ_1247.

Structurei

Secondary structure

1
180
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1511Combined sources
Helixi16 – 183Combined sources
Helixi19 – 224Combined sources
Helixi24 – 3916Combined sources
Beta strandi41 – 466Combined sources
Helixi49 – 6416Combined sources
Beta strandi69 – 713Combined sources
Beta strandi85 – 939Combined sources
Helixi96 – 10611Combined sources
Beta strandi112 – 1187Combined sources
Helixi121 – 1255Combined sources
Beta strandi127 – 1315Combined sources
Helixi144 – 16421Combined sources
Helixi169 – 1757Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JEOX-ray2.00A1-180[»]
ProteinModelPortaliQ58644.
SMRiQ58644. Positions 4-180.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58644.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 167135SISPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni90 – 956Substrate-bindingCurated

Sequence similaritiesi

Belongs to the SIS family. PHI subfamily.Curated
Contains 1 SIS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG00068. Archaea.
COG0794. LUCA.
InParanoidiQ58644.
KOiK08094.
OMAiFAMRLRH.
PhylomeDBiQ58644.

Family and domain databases

InterProiIPR017552. PHI/rmpB.
IPR001347. SIS.
[Graphical view]
PfamiPF01380. SIS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03127. RuMP_HxlB. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58644-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLEELDIV SNNILILKKF YTNDEWKNKL DSLIDRIIKA KKIFIFGVGR
60 70 80 90 100
SGYIGRCFAM RLMHLGFKSY FVGETTTPSY EKDDLLILIS GSGRTESVLT
110 120 130 140 150
VAKKAKNINN NIIAIVCECG NVVEFADLTI PLEVKKSKYL PMGTTFEETA
160 170 180
LIFLDLVIAE IMKRLNLDES EIIKRHCNLL
Length:180
Mass (Da):20,443
Last modified:November 1, 1996 - v1
Checksum:i7C3D607BCBD4AA0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99251.1.
PIRiF64455.

Genome annotation databases

EnsemblBacteriaiAAB99251; AAB99251; MJ_1247.
KEGGimja:MJ_1247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99251.1.
PIRiF64455.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JEOX-ray2.00A1-180[»]
ProteinModelPortaliQ58644.
SMRiQ58644. Positions 4-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99251; AAB99251; MJ_1247.
KEGGimja:MJ_1247.

Phylogenomic databases

eggNOGiarCOG00068. Archaea.
COG0794. LUCA.
InParanoidiQ58644.
KOiK08094.
OMAiFAMRLRH.
PhylomeDBiQ58644.

Enzyme and pathway databases

UniPathwayiUPA00293.
BRENDAi5.3.1.27. 3260.

Miscellaneous databases

EvolutionaryTraceiQ58644.

Family and domain databases

InterProiIPR017552. PHI/rmpB.
IPR001347. SIS.
[Graphical view]
PfamiPF01380. SIS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03127. RuMP_HxlB. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHI_METJA
AccessioniPrimary (citable) accession number: Q58644
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.