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Protein

Translation initiation factor 5A

Gene

eif5a

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions by promoting the formation of the first peptide bond.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 5A
Alternative name(s):
Hypusine-containing protein
eIF-5A
Gene namesi
Name:eif5a
Ordered Locus Names:MJ1228
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001424931 – 132Translation initiation factor 5AAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37Hypusine1 Publication1

Keywords - PTMi

Hypusine

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_1228.

Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Helixi9 – 11Combined sources3
Beta strandi16 – 20Combined sources5
Beta strandi23 – 32Combined sources10
Beta strandi37 – 39Combined sources3
Beta strandi42 – 52Combined sources11
Beta strandi55 – 61Combined sources7
Beta strandi64 – 69Combined sources6
Beta strandi71 – 82Combined sources12
Beta strandi85 – 90Combined sources6
Turni91 – 93Combined sources3
Beta strandi96 – 100Combined sources5
Beta strandi113 – 119Combined sources7
Beta strandi122 – 128Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EIFX-ray1.90A1-132[»]
2EIFX-ray1.80A1-132[»]
ProteinModelPortaliQ58625.
SMRiQ58625.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58625.

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.Curated

Phylogenomic databases

eggNOGiarCOG04277. Archaea.
COG0231. LUCA.
InParanoidiQ58625.
KOiK03263.
OMAiETYETIT.
PhylomeDBiQ58625.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_00085. eIF_5A. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR022847. Transl_elong_IF5A_arc.
IPR020189. Transl_elong_IF5A_C.
IPR013185. Transl_elong_KOW-like.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiPF08207. EFP_N. 1 hit.
PF01287. eIF-5a. 1 hit.
[Graphical view]
PIRSFiPIRSF003025. eIF5A. 1 hit.
SMARTiSM01376. eIF-5a. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiPS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58625-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGTKQVNVG SLKVGQYVMI DGVPCEIVDI SVSKPGKHGG AKARVVGIGI
60 70 80 90 100
FEKVKKEFVA PTSSKVEVPI IDRRKGQVLA IMGDMVQIMD LQTYETLELP
110 120 130
IPEGIEGLEP GGEVEYIEAV GQYKITRVIG GK
Length:132
Mass (Da):14,180
Last modified:December 15, 1998 - v2
Checksum:i5B0F48905B0DCF69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99231.1.
RefSeqiWP_010870740.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99231; AAB99231; MJ_1228.
GeneIDi1452124.
KEGGimja:MJ_1228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99231.1.
RefSeqiWP_010870740.1. NC_000909.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EIFX-ray1.90A1-132[»]
2EIFX-ray1.80A1-132[»]
ProteinModelPortaliQ58625.
SMRiQ58625.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1228.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99231; AAB99231; MJ_1228.
GeneIDi1452124.
KEGGimja:MJ_1228.

Phylogenomic databases

eggNOGiarCOG04277. Archaea.
COG0231. LUCA.
InParanoidiQ58625.
KOiK03263.
OMAiETYETIT.
PhylomeDBiQ58625.

Miscellaneous databases

EvolutionaryTraceiQ58625.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_00085. eIF_5A. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR022847. Transl_elong_IF5A_arc.
IPR020189. Transl_elong_IF5A_C.
IPR013185. Transl_elong_KOW-like.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiPF08207. EFP_N. 1 hit.
PF01287. eIF-5a. 1 hit.
[Graphical view]
PIRSFiPIRSF003025. eIF5A. 1 hit.
SMARTiSM01376. eIF-5a. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiPS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF5A_METJA
AccessioniPrimary (citable) accession number: Q58625
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.