Putative cation-transporting ATPase MJ1226 - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Putative cation-transporting ATPase MJ1226
EC=3.6.3.-

Gene names

Ordered Locus Names:

MJ1226

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	805 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + H₂O = ADP + phosphate.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro cation transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 805

805

Putative cation-transporting ATPase MJ1226

PRO_0000046427

Regions

Transmembrane

53 – 73

21

Helical; Potential

Transmembrane

75 – 95

21

Helical; Potential

Transmembrane

226 – 246

21

Helical; Potential

Transmembrane

258 – 278

21

Helical; Potential

Transmembrane

615 – 637

23

Helical; Potential

Transmembrane

641 – 663

23

Helical; Potential

Transmembrane

680 – 700

21

Helical; Potential

Transmembrane

712 – 734

23

Helical; Potential

Transmembrane

747 – 769

23

Helical; Potential

Transmembrane

773 – 790

18

Helical; Potential

Sites

Active site

311

1

4-aspartylphosphate intermediate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q58623 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8E63D3F7E47668CD
Show »

FASTA

805

89,618

        10         20         30         40         50         60 
MWGVVMNVEE IEEEYKTSIK TGLSTEEAKK RLKIYGYNEI PEKKVHPIIK FLSYFWNPIA 

        70         80         90        100        110        120 
WMIEIAAILS AIIKHWVDFV IILILLLVNG VVGFWEEYKA ENVIEFLKQK MALNARVLRD 

       130        140        150        160        170        180 
GKWQIIPAKE LVPGDVVRIR IGDIVPADII LVDGDYLVVD ESALTGESLP VEKKIGDIAY 

       190        200        210        220        230        240 
SGSIVKKGEM TGIVKATGLN TYFGKTVKLV EKAEKVSSYQ KMIIKIGDYL IVLAVILIAI 

       250        260        270        280        290        300 
MVAVELFRGK SLIETAQFAL VLAVSAIPAA MPAVLSITMA IGALNLAKKD AIVKKLVAIE 

       310        320        330        340        350        360 
ELAGVDILCS DKTGTLTKNQ LVCGEIIALN GFSKEDVVLF AALASREEDA DAIDMAILNE 

       370        380        390        400        410        420 
AKKLGLMEKI KNYKIKKFIP FDPVIKRTEA EVTNDEEFKV SKGAPQVILD LCNADEELRR 

       430        440        450        460        470        480 
KVEEIVDKLA ENGYRALGVA VYKNGRWHFA GIIPLYDPPR EDAPLAVKKI KELGVIIKMV 

       490        500        510        520        530        540 
TGDHVAIAKN IARMLGIGDK IISISELLKK LKRGEIKEEK FDEIVEEADG FAEVFPEHKY 

       550        560        570        580        590        600 
KIVDSLQKRG HLVAMTGDGV NDAPALKKAD CGIAVSNATD AARAAADIVL LSPGISVIVD 

       610        620        630        640        650        660 
AIQEARRIFQ RMESYVIYRI TETIRILFFV ELCILILGIY PITALMIVLL AILNDIPILA 

       670        680        690        700        710        720 
IAYDNVVEPK SPVRWRMREI LMLSTALGLS GVVSSFLIFY ISDVFLHLTI AELQSFVFLK 

       730        740        750        760        770        780 
LILAGHATIF VTRIRDRLWK KPYPSKLLFW GVMGTNIIGT IVAAEGIFMA PIGWDLALFM 

       790        800 
WLYAHVWMLI NDEIKMILLK RLKID

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References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii."
Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G.

Venter J.C.
Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB99229.1.
PIR	A64453.
RefSeq	NP_248221.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q58623.
ModBase	Search...
Protein family/group databases
TCDB	3.A.3.3.4. P-type ATPase (P-ATPase) superfamily.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1452122.
GenomeReviews	Gene locus MJ1226 in contig L77117_GR.
KEGG	mja:MJ_1226.
NMPDR	fig\|243232.1.peg.1258.
TIGR	MJ1226.
Phylogenomic databases
HOGENOM	HBG706356.
OMA	FARIEGC.
ProtClustDB	CLSK2484326.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_1226-MONOMER.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR000695. ATPase_P-typ_H-transp. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR006534. ATPase_P-typ_PM_proton-efflux. IPR023298. ATPase_P-typ_TM_dom. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 2 hits. G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 2 hits.
KO	K01535.
PANTHER	PTHR24093:SF61. PTHR24093:SF61. 1 hit.
Pfam	PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01647. ATPase-IIIA_H. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y1226_METJA

Accession

Primary (citable) accession number: Q58623

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents