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Q58617

- Y1220_METJA

UniProt

Q58617 - Y1220_METJA

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Protein

Uncharacterized adenine-specific methylase MJ1220

Gene

MJ1220

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei303 – 3031S-adenosyl-L-methionineBy similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. N-methyltransferase activity Source: InterPro
  3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3905. M.MjaORF1220P.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized adenine-specific methylase MJ1220 (EC:2.1.1.72)
Gene namesi
Ordered Locus Names:MJ1220
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578Uncharacterized adenine-specific methylase MJ1220PRO_0000088001Add
BLAST

Proteomic databases

PRIDEiQ58617.

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ1220.

Structurei

3D structure databases

ProteinModelPortaliQ58617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni280 – 2823S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0286.
InParanoidiQ58617.
KOiK03427.
OMAiVANPPWN.
PhylomeDBiQ58617.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR022749. D12N6_MeTrfase_N.
IPR003356. DNA_methylase_A-5.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF12161. HsdM_N. 1 hit.
PF02384. N6_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00507. N12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58617-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLRNVEPRF LKAYNILMDK FGLFPFTYDM AEKVLKDNYE NVNEVLSKLA
60 70 80 90 100
DAGLLEKTAK KEDKRKKIYK IKPLTTEKIE KVSKDKLIGL LKQGADLIRT
110 120 130 140 150
QVDYKVLLLF LFFKAISDKY LLKVEELKKE FEDLDEEDIY VLANEEILEL
160 170 180 190 200
YDVEGKKLYV WHEVANNPED FINALNKIVE MNKEKLSGLD ELIKRTGLPT
210 220 230 240 250
LFENENRHIV QHLINLFSRA DFSEASYDIL GDAYEWTLNY FAPTKAKEGE
260 270 280 290 300
VYTPIEVSKL IAHLVEPKDD EVILDPACGS GSMLIEQYRF AGSNPNIVLV
310 320 330 340 350
GQERNDVTAV LAKLNFILHG INLKDAKVFI GDSLLNPKFE SFIXEVKGTG
360 370 380 390 400
KADKVVANPP WNQDGYDENT LKVNEKYKDI YMYGFPNKNS ADWAWVQLIN
410 420 430 440 450
YYTEKKAGIV LDSGALFRGG KEKTIRKRFV DDDLIEAVVL LPEKLFYNCP
460 470 480 490 500
APGIILILNK NKPEERKGKI LFINASNEYI KHPEVKKLNK LSDENIEKIA
510 520 530 540 550
KAYKEFKDVD GFCKVVDIEE IRKNDYNLNV SLYISPIEED EDVDLGEVYE
560 570
ELNKLHNEYL EKFEVVKGYL EEINGLIK
Length:578
Mass (Da):66,638
Last modified:November 1, 1997 - v1
Checksum:i5339ED873EF8E9E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99225.1.
PIRiC64452.
RefSeqiNP_248215.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99225; AAB99225; MJ_1220.
GeneIDi1452116.
KEGGimja:MJ_1220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99225.1 .
PIRi C64452.
RefSeqi NP_248215.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58617.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ1220.

Protein family/group databases

REBASEi 3905. M.MjaORF1220P.

Proteomic databases

PRIDEi Q58617.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB99225 ; AAB99225 ; MJ_1220 .
GeneIDi 1452116.
KEGGi mja:MJ_1220.

Phylogenomic databases

eggNOGi COG0286.
InParanoidi Q58617.
KOi K03427.
OMAi VANPPWN.
PhylomeDBi Q58617.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR022749. D12N6_MeTrfase_N.
IPR003356. DNA_methylase_A-5.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF12161. HsdM_N. 1 hit.
PF02384. N6_Mtase. 1 hit.
[Graphical view ]
PRINTSi PR00507. N12N6MTFRASE.
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS00092. N6_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiY1220_METJA
AccessioniPrimary (citable) accession number: Q58617
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3