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Q58617

- Y1220_METJA

UniProt

Q58617 - Y1220_METJA

Protein

Uncharacterized adenine-specific methylase MJ1220

Gene

MJ1220

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei303 – 3031S-adenosyl-L-methionineBy similarity

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3905. M.MjaORF1220P.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized adenine-specific methylase MJ1220 (EC:2.1.1.72)
    Gene namesi
    Ordered Locus Names:MJ1220
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 578578Uncharacterized adenine-specific methylase MJ1220PRO_0000088001Add
    BLAST

    Proteomic databases

    PRIDEiQ58617.

    Interactioni

    Protein-protein interaction databases

    STRINGi243232.MJ1220.

    Structurei

    3D structure databases

    ProteinModelPortaliQ58617.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni280 – 2823S-adenosyl-L-methionine bindingBy similarity

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0286.
    KOiK03427.
    OMAiVANPPWN.
    PhylomeDBiQ58617.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR022749. D12N6_MeTrfase_N.
    IPR003356. DNA_methylase_A-5.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF12161. HsdM_N. 1 hit.
    PF02384. N6_Mtase. 1 hit.
    [Graphical view]
    PRINTSiPR00507. N12N6MTFRASE.
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q58617-1 [UniParc]FASTAAdd to Basket

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    MKLRNVEPRF LKAYNILMDK FGLFPFTYDM AEKVLKDNYE NVNEVLSKLA    50
    DAGLLEKTAK KEDKRKKIYK IKPLTTEKIE KVSKDKLIGL LKQGADLIRT 100
    QVDYKVLLLF LFFKAISDKY LLKVEELKKE FEDLDEEDIY VLANEEILEL 150
    YDVEGKKLYV WHEVANNPED FINALNKIVE MNKEKLSGLD ELIKRTGLPT 200
    LFENENRHIV QHLINLFSRA DFSEASYDIL GDAYEWTLNY FAPTKAKEGE 250
    VYTPIEVSKL IAHLVEPKDD EVILDPACGS GSMLIEQYRF AGSNPNIVLV 300
    GQERNDVTAV LAKLNFILHG INLKDAKVFI GDSLLNPKFE SFIXEVKGTG 350
    KADKVVANPP WNQDGYDENT LKVNEKYKDI YMYGFPNKNS ADWAWVQLIN 400
    YYTEKKAGIV LDSGALFRGG KEKTIRKRFV DDDLIEAVVL LPEKLFYNCP 450
    APGIILILNK NKPEERKGKI LFINASNEYI KHPEVKKLNK LSDENIEKIA 500
    KAYKEFKDVD GFCKVVDIEE IRKNDYNLNV SLYISPIEED EDVDLGEVYE 550
    ELNKLHNEYL EKFEVVKGYL EEINGLIK 578
    Length:578
    Mass (Da):66,638
    Last modified:November 1, 1997 - v1
    Checksum:i5339ED873EF8E9E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99225.1.
    PIRiC64452.
    RefSeqiNP_248215.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB99225; AAB99225; MJ_1220.
    GeneIDi1452116.
    KEGGimja:MJ_1220.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99225.1 .
    PIRi C64452.
    RefSeqi NP_248215.1. NC_000909.1.

    3D structure databases

    ProteinModelPortali Q58617.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ1220.

    Protein family/group databases

    REBASEi 3905. M.MjaORF1220P.

    Proteomic databases

    PRIDEi Q58617.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB99225 ; AAB99225 ; MJ_1220 .
    GeneIDi 1452116.
    KEGGi mja:MJ_1220.

    Phylogenomic databases

    eggNOGi COG0286.
    KOi K03427.
    OMAi VANPPWN.
    PhylomeDBi Q58617.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR022749. D12N6_MeTrfase_N.
    IPR003356. DNA_methylase_A-5.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF12161. HsdM_N. 1 hit.
    PF02384. N6_Mtase. 1 hit.
    [Graphical view ]
    PRINTSi PR00507. N12N6MTFRASE.
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

    Entry informationi

    Entry nameiY1220_METJA
    AccessioniPrimary (citable) accession number: Q58617
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3