Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Modification methylase MjaVI

Gene

mjaVIM

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence CCGG, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the MjaVI endonuclease.Curated

Catalytic activityi

S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N(4)-methylcytosine.

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. N-methyltransferase activity Source: InterPro
  3. site-specific DNA-methyltransferase (cytosine-N4-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3893. M.MjaVI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase MjaVI (EC:2.1.1.113)
Short name:
M.MjaVI
Alternative name(s):
N-4 cytosine-specific methyltransferase MjaVI
Gene namesi
Name:mjaVIM
Ordered Locus Names:MJ1209
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Modification methylase MjaVIPRO_0000087939Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ58606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0863.
PhylomeDBiQ58606.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002941. DNA_methylase_N4/N6.
IPR017985. MeTrfase_CN4_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00508. S21N4MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00093. N4_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVIIVKIWN KINGITLIND DFLNVDLPNE SIDLIVTSPP YNVGIDYNQH
60 70 80 90 100
DDTIPYEEYL DWTKQWLKKA LTLLKKDGRL CLNIPLDKNK GGIKPVYADI
110 120 130 140 150
VKIALDVGFK YQTTIIWNEQ NISRRTAWGS FMSASAPYVI APVETIVVLY
160 170 180 190
KESWKKLSKG ESDITKEEFI EWTNGLWTFP GESKKELDIQ HHFR
Length:194
Mass (Da):22,461
Last modified:May 31, 1998 - v2
Checksum:i6DB2BAEEAEAEBC10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99220.1.
RefSeqiWP_010870962.1. NC_000909.1.
YP_003727984.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99220; AAB99220; MJ_1209.
GeneIDi9348047.
KEGGimja:MJ_1209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99220.1.
RefSeqiWP_010870962.1. NC_000909.1.
YP_003727984.1. NC_000909.1.

3D structure databases

ProteinModelPortaliQ58606.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

REBASEi3893. M.MjaVI.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99220; AAB99220; MJ_1209.
GeneIDi9348047.
KEGGimja:MJ_1209.

Phylogenomic databases

eggNOGiCOG0863.
PhylomeDBiQ58606.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002941. DNA_methylase_N4/N6.
IPR017985. MeTrfase_CN4_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00508. S21N4MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00093. N4_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiMTM6_METJA
AccessioniPrimary (citable) accession number: Q58606
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2000
Last sequence update: May 31, 1998
Last modified: February 3, 2015
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.