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Q58606

- MTM6_METJA

UniProt

Q58606 - MTM6_METJA

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Protein

Modification methylase MjaVI

Gene

mjaVIM

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence CCGG, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the MjaVI endonuclease.Curated

Catalytic activityi

S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N(4)-methylcytosine.

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. N-methyltransferase activity Source: InterPro
  3. site-specific DNA-methyltransferase (cytosine-N4-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3893. M.MjaVI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase MjaVI (EC:2.1.1.113)
Short name:
M.MjaVI
Alternative name(s):
N-4 cytosine-specific methyltransferase MjaVI
Gene namesi
Name:mjaVIM
Ordered Locus Names:MJ1209
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Modification methylase MjaVIPRO_0000087939Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ58606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0863.
OMAiSFMSASA.
PhylomeDBiQ58606.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002941. DNA_methylase_N4/N6.
IPR017985. MeTrfase_CN4_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00508. S21N4MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00093. N4_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58606-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVIIVKIWN KINGITLIND DFLNVDLPNE SIDLIVTSPP YNVGIDYNQH
60 70 80 90 100
DDTIPYEEYL DWTKQWLKKA LTLLKKDGRL CLNIPLDKNK GGIKPVYADI
110 120 130 140 150
VKIALDVGFK YQTTIIWNEQ NISRRTAWGS FMSASAPYVI APVETIVVLY
160 170 180 190
KESWKKLSKG ESDITKEEFI EWTNGLWTFP GESKKELDIQ HHFR
Length:194
Mass (Da):22,461
Last modified:June 1, 1998 - v2
Checksum:i6DB2BAEEAEAEBC10
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99220.1.
RefSeqiYP_003727984.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99220; AAB99220; MJ_1209.
GeneIDi9348047.
KEGGimja:MJ_1209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99220.1 .
RefSeqi YP_003727984.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58606.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 3893. M.MjaVI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB99220 ; AAB99220 ; MJ_1209 .
GeneIDi 9348047.
KEGGi mja:MJ_1209.

Phylogenomic databases

eggNOGi COG0863.
OMAi SFMSASA.
PhylomeDBi Q58606.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR002941. DNA_methylase_N4/N6.
IPR017985. MeTrfase_CN4_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF01555. N6_N4_Mtase. 1 hit.
[Graphical view ]
PRINTSi PR00508. S21N4MTFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS00093. N4_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiMTM6_METJA
AccessioniPrimary (citable) accession number: Q58606
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3