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Q58600

- MT52_METJA

UniProt

Q58600 - MT52_METJA

Protein

Probable modification methylase MJ1200

Gene

MJ1200

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei133 – 1331PROSITE-ProRule annotation

    GO - Molecular functioni

    1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
    2. DNA binding Source: InterPro

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3906. M.MjaORF1200P.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable modification methylase MJ1200 (EC:2.1.1.37)
    Alternative name(s):
    Cytosine-specific methyltransferase MJ1200
    M.MjaVIIP
    Gene namesi
    Ordered Locus Names:MJ1200
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366Probable modification methylase MJ1200PRO_0000087917Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243232.MJ1200.

    Structurei

    3D structure databases

    ProteinModelPortaliQ58600.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 366362SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
    Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0270.
    KOiK00558.
    OMAiRDVPNHE.
    PhylomeDBiQ58600.

    Family and domain databases

    Gene3Di3.40.50.150. 2 hits.
    InterProiIPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10629. PTHR10629. 1 hit.
    PfamiPF00145. DNA_methylase. 2 hits.
    [Graphical view]
    PRINTSiPR00105. C5METTRFRASE.
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS51679. SAM_MT_C5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q58600-1 [UniParc]FASTAAdd to Basket

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    MVIMLKFIDL FCGCGGFSRG FVEEGFEPLV AIELNEDAAF SYALNFNGQI    50
    YEKIRPGEFK LKELKGYVGI YPFKFPFEEE DIKWLKRLGT LNEKTKKLSP 100
    VVINDDIREI HAIEIEKFIK NKKVDVIIGG PPCEGYTGAN PKREKNPYDR 150
    LYKDETGRLV LEYIRIVGDL QPKIFVMENV PGIKEVRGAI IKEFREIGYE 200
    DVYFNTLRAE DYGNPSVRRR VFVSNIEINP EKTQPKTVIE AIGDLMYKGR 250
    DVPNHEFAAL PARFRKRVHK LGWGDAFIYF KGANRRLGNY IRLHPLKLAE 300
    TVMGKRFFIH PYEDRLLTPR EQARLMSYPD YHLFAGGIRS CYNQIGESVP 350
    VALSRAIARV IKENLK 366
    Length:366
    Mass (Da):42,269
    Last modified:November 1, 1996 - v1
    Checksum:i9D5C60CA603FBCFE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99203.1.
    PIRiG64449.
    RefSeqiNP_248195.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB99203; AAB99203; MJ_1200.
    GeneIDi1452095.
    KEGGimja:MJ_1200.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99203.1 .
    PIRi G64449.
    RefSeqi NP_248195.1. NC_000909.1.

    3D structure databases

    ProteinModelPortali Q58600.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ1200.

    Protein family/group databases

    REBASEi 3906. M.MjaORF1200P.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB99203 ; AAB99203 ; MJ_1200 .
    GeneIDi 1452095.
    KEGGi mja:MJ_1200.

    Phylogenomic databases

    eggNOGi COG0270.
    KOi K00558.
    OMAi RDVPNHE.
    PhylomeDBi Q58600.

    Family and domain databases

    Gene3Di 3.40.50.150. 2 hits.
    InterProi IPR001525. C5_MeTfrase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10629. PTHR10629. 1 hit.
    Pfami PF00145. DNA_methylase. 2 hits.
    [Graphical view ]
    PRINTSi PR00105. C5METTRFRASE.
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS51679. SAM_MT_C5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

    Entry informationi

    Entry nameiMT52_METJA
    AccessioniPrimary (citable) accession number: Q58600
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3