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Protein

Probable modification methylase MJ1200

Gene

MJ1200

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331PROSITE-ProRule annotation

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3906. M.MjaORF1200P.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable modification methylase MJ1200 (EC:2.1.1.37)
Alternative name(s):
Cytosine-specific methyltransferase MJ1200
M.MjaVIIP
Gene namesi
Ordered Locus Names:MJ1200
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Probable modification methylase MJ1200PRO_0000087917Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ1200.

Structurei

3D structure databases

ProteinModelPortaliQ58600.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 366362SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0270.
InParanoidiQ58600.
KOiK00558.
OMAiRDVPNHE.
PhylomeDBiQ58600.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58600-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIMLKFIDL FCGCGGFSRG FVEEGFEPLV AIELNEDAAF SYALNFNGQI
60 70 80 90 100
YEKIRPGEFK LKELKGYVGI YPFKFPFEEE DIKWLKRLGT LNEKTKKLSP
110 120 130 140 150
VVINDDIREI HAIEIEKFIK NKKVDVIIGG PPCEGYTGAN PKREKNPYDR
160 170 180 190 200
LYKDETGRLV LEYIRIVGDL QPKIFVMENV PGIKEVRGAI IKEFREIGYE
210 220 230 240 250
DVYFNTLRAE DYGNPSVRRR VFVSNIEINP EKTQPKTVIE AIGDLMYKGR
260 270 280 290 300
DVPNHEFAAL PARFRKRVHK LGWGDAFIYF KGANRRLGNY IRLHPLKLAE
310 320 330 340 350
TVMGKRFFIH PYEDRLLTPR EQARLMSYPD YHLFAGGIRS CYNQIGESVP
360
VALSRAIARV IKENLK
Length:366
Mass (Da):42,269
Last modified:November 1, 1996 - v1
Checksum:i9D5C60CA603FBCFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99203.1.
PIRiG64449.
RefSeqiNP_248195.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99203; AAB99203; MJ_1200.
GeneIDi1452095.
KEGGimja:MJ_1200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99203.1.
PIRiG64449.
RefSeqiNP_248195.1. NC_000909.1.

3D structure databases

ProteinModelPortaliQ58600.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ1200.

Protein family/group databases

REBASEi3906. M.MjaORF1200P.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99203; AAB99203; MJ_1200.
GeneIDi1452095.
KEGGimja:MJ_1200.

Phylogenomic databases

eggNOGiCOG0270.
InParanoidiQ58600.
KOiK00558.
OMAiRDVPNHE.
PhylomeDBiQ58600.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51679. SAM_MT_C5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiMT52_METJA
AccessioniPrimary (citable) accession number: Q58600
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 4, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.