ID   RISC_METJA              Reviewed;         156 AA.
AC   Q58584;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 124.
DE   RecName: Full=Riboflavin synthase;
DE            EC=2.5.1.9;
GN   Name=ribC; OrderedLocusNames=MJ1184;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-
CC         ribitylamino)uracil + riboflavin; Xref=Rhea:RHEA:20772,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15934, ChEBI:CHEBI:57986,
CC         ChEBI:CHEBI:58201; EC=2.5.1.9;
CC   -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; riboflavin
CC       from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-
CC       ribitylamino)uracil: step 2/2.
CC   -!- SIMILARITY: Belongs to the DMRL synthase family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99185.1; -; Genomic_DNA.
DR   PIR; G64447; G64447.
DR   RefSeq; WP_010870697.1; NC_000909.1.
DR   PDB; 2B98; X-ray; 2.30 A; A/B/C/D/E=1-156.
DR   PDB; 2B99; X-ray; 2.22 A; A/B/C/D/E=1-156.
DR   PDB; 4Y7J; X-ray; 4.10 A; A/B/C/D/E=1-156.
DR   PDB; 4Y7K; X-ray; 3.50 A; A/B/C/D/E=2-156.
DR   PDB; 5IM5; X-ray; 3.70 A; A/B/C/D/E/F/G/H/I/J/K/M/O/Q/S=1-156.
DR   PDBsum; 2B98; -.
DR   PDBsum; 2B99; -.
DR   PDBsum; 4Y7J; -.
DR   PDBsum; 4Y7K; -.
DR   PDBsum; 5IM5; -.
DR   AlphaFoldDB; Q58584; -.
DR   SMR; Q58584; -.
DR   STRING; 243232.MJ_1184; -.
DR   PaxDb; 243232-MJ_1184; -.
DR   EnsemblBacteria; AAB99185; AAB99185; MJ_1184.
DR   GeneID; 1452082; -.
DR   KEGG; mja:MJ_1184; -.
DR   eggNOG; arCOG01322; Archaea.
DR   HOGENOM; CLU_1682776_0_0_2; -.
DR   InParanoid; Q58584; -.
DR   OrthoDB; 23911at2157; -.
DR   PhylomeDB; Q58584; -.
DR   BioCyc; MetaCyc:MONOMER-14602; -.
DR   BRENDA; 2.5.1.9; 3260.
DR   UniPathway; UPA00275; UER00405.
DR   EvolutionaryTrace; Q58584; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0009349; C:riboflavin synthase complex; IEA:InterPro.
DR   GO; GO:0004746; F:riboflavin synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd09210; Riboflavin_synthase_archaeal; 1.
DR   Gene3D; 3.40.50.960; Lumazine/riboflavin synthase; 1.
DR   InterPro; IPR002180; LS/RS.
DR   InterPro; IPR036467; LS/RS_sf.
DR   InterPro; IPR006399; Ribfl_synth_arc.
DR   NCBIfam; TIGR01506; ribC_arch; 1.
DR   Pfam; PF00885; DMRL_synthase; 1.
DR   PIRSF; PIRSF015750; Ribfl_synth_arc; 1.
DR   SUPFAM; SSF52121; Lumazine synthase; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Riboflavin biosynthesis; Transferase.
FT   CHAIN           1..156
FT                   /note="Riboflavin synthase"
FT                   /id="PRO_0000134860"
FT   STRAND          4..12
FT                   /evidence="ECO:0007829|PDB:2B99"
FT   HELIX           18..28
FT                   /evidence="ECO:0007829|PDB:2B99"
FT   STRAND          33..41
FT                   /evidence="ECO:0007829|PDB:2B99"
FT   HELIX           42..44
FT                   /evidence="ECO:0007829|PDB:2B99"
FT   HELIX           45..55
FT                   /evidence="ECO:0007829|PDB:2B99"
FT   STRAND          59..65
FT                   /evidence="ECO:0007829|PDB:2B99"
FT   HELIX           71..91
FT                   /evidence="ECO:0007829|PDB:2B99"
FT   STRAND          95..99
FT                   /evidence="ECO:0007829|PDB:2B99"
FT   HELIX           102..104
FT                   /evidence="ECO:0007829|PDB:2B99"
FT   STRAND          105..107
FT                   /evidence="ECO:0007829|PDB:2B99"
FT   HELIX           108..131
FT                   /evidence="ECO:0007829|PDB:2B99"
FT   HELIX           133..138
FT                   /evidence="ECO:0007829|PDB:2B99"
FT   TURN            139..141
FT                   /evidence="ECO:0007829|PDB:2B99"
FT   STRAND          146..148
FT                   /evidence="ECO:0007829|PDB:2B98"
SQ   SEQUENCE   156 AA;  17495 MW;  6D65112C6B1320F5 CRC64;
     MTKKVGIVDT TFARVDMASI AIKKLKELSP NIKIIRKTVP GIKDLPVACK KLLEEEGCDI
     VMALGMPGKA EKDKVCAHEA SLGLMLAQLM TNKHIIEVFV HEDEAKDDKE LDWLAKRRAE
     EHAENVYYLL FKPEYLTRMA GKGLRQGFED AGPARE
//