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Protein

Riboflavin synthase

Gene

ribC

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Pathwayi: riboflavin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 6,7-dimethyl-8-ribityllumazine synthase (ribH)
  2. Riboflavin synthase (ribC)
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processRiboflavin biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14602
MJAN243232:G1GKE-1282-MONOMER
BRENDAi2.5.1.9 3260
UniPathwayiUPA00275; UER00405

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Gene namesi
Name:ribC
Ordered Locus Names:MJ1184
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001348601 – 156Riboflavin synthaseAdd BLAST156

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_1184

Structurei

Secondary structure

1156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 12Combined sources9
Helixi18 – 28Combined sources11
Beta strandi33 – 41Combined sources9
Helixi42 – 44Combined sources3
Helixi45 – 55Combined sources11
Beta strandi59 – 65Combined sources7
Helixi71 – 91Combined sources21
Beta strandi95 – 99Combined sources5
Helixi102 – 104Combined sources3
Beta strandi105 – 107Combined sources3
Helixi108 – 131Combined sources24
Helixi133 – 138Combined sources6
Turni139 – 141Combined sources3
Beta strandi146 – 148Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B98X-ray2.30A/B/C/D/E1-156[»]
2B99X-ray2.22A/B/C/D/E1-156[»]
4Y7JX-ray4.10A/B/C/D/E1-156[»]
4Y7KX-ray3.50A/B/C/D/E2-156[»]
5IM5X-ray3.70A/B/C/D/E/F/G/H/I/J/K/M/O/Q/S1-156[»]
ProteinModelPortaliQ58584
SMRiQ58584
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58584

Family & Domainsi

Sequence similaritiesi

Belongs to the DMRL synthase family.Curated

Phylogenomic databases

eggNOGiarCOG01322 Archaea
COG1731 LUCA
InParanoidiQ58584
KOiK00793
OMAiLMTNTHI
OrthoDBiPOG093Z0DB2
PhylomeDBiQ58584

Family and domain databases

CDDicd09210 Riboflavin_synthase_archaeal, 1 hit
Gene3Di3.40.50.960, 1 hit
InterProiView protein in InterPro
IPR002180 LS/RS
IPR036467 LS/RS_sf
IPR006399 Ribfl_synth_arc
PfamiView protein in Pfam
PF00885 DMRL_synthase, 1 hit
PIRSFiPIRSF015750 Ribfl_synth_arc, 1 hit
SUPFAMiSSF52121 SSF52121, 1 hit
TIGRFAMsiTIGR01506 ribC_arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q58584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKVGIVDT TFARVDMASI AIKKLKELSP NIKIIRKTVP GIKDLPVACK
60 70 80 90 100
KLLEEEGCDI VMALGMPGKA EKDKVCAHEA SLGLMLAQLM TNKHIIEVFV
110 120 130 140 150
HEDEAKDDKE LDWLAKRRAE EHAENVYYLL FKPEYLTRMA GKGLRQGFED

AGPARE
Length:156
Mass (Da):17,495
Last modified:November 1, 1996 - v1
Checksum:i6D65112C6B1320F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB99185.1
PIRiG64447
RefSeqiWP_010870697.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB99185; AAB99185; MJ_1184
GeneIDi1452082
KEGGimja:MJ_1184

Similar proteinsi

Entry informationi

Entry nameiRISC_METJA
AccessioniPrimary (citable) accession number: Q58584
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health