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Protein

Riboflavin synthase

Gene

ribC

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Pathwayi: riboflavin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 6,7-dimethyl-8-ribityllumazine synthase (ribH)
  2. Riboflavin synthase (ribC)
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Riboflavin biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14602.
BRENDAi2.5.1.9. 3260.
UniPathwayiUPA00275; UER00405.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Gene namesi
Name:ribC
Ordered Locus Names:MJ1184
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001348601 – 156Riboflavin synthaseAdd BLAST156

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_1184.

Structurei

Secondary structure

1156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 12Combined sources9
Helixi18 – 28Combined sources11
Beta strandi33 – 41Combined sources9
Helixi42 – 44Combined sources3
Helixi45 – 55Combined sources11
Beta strandi59 – 65Combined sources7
Helixi71 – 91Combined sources21
Beta strandi95 – 99Combined sources5
Helixi102 – 104Combined sources3
Beta strandi105 – 107Combined sources3
Helixi108 – 131Combined sources24
Helixi133 – 138Combined sources6
Turni139 – 141Combined sources3
Beta strandi146 – 148Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B98X-ray2.30A/B/C/D/E1-156[»]
2B99X-ray2.22A/B/C/D/E1-156[»]
4Y7JX-ray4.10A/B/C/D/E1-156[»]
4Y7KX-ray3.50A/B/C/D/E2-156[»]
5IM5X-ray3.70A/B/C/D/E/F/G/H/I/J/K/M/O/Q/S1-156[»]
ProteinModelPortaliQ58584.
SMRiQ58584.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58584.

Family & Domainsi

Sequence similaritiesi

Belongs to the DMRL synthase family.Curated

Phylogenomic databases

eggNOGiarCOG01322. Archaea.
COG1731. LUCA.
InParanoidiQ58584.
KOiK00793.
OMAiGIVDTTF.
PhylomeDBiQ58584.

Family and domain databases

CDDicd09210. Riboflavin_synthase_archaeal. 1 hit.
Gene3Di3.40.50.960. 1 hit.
InterProiIPR002180. DMRL_synthase.
IPR006399. Ribfl_synth_arc.
[Graphical view]
PfamiPF00885. DMRL_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF015750. Ribfl_synth_arc. 1 hit.
SUPFAMiSSF52121. SSF52121. 1 hit.
TIGRFAMsiTIGR01506. ribC_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKVGIVDT TFARVDMASI AIKKLKELSP NIKIIRKTVP GIKDLPVACK
60 70 80 90 100
KLLEEEGCDI VMALGMPGKA EKDKVCAHEA SLGLMLAQLM TNKHIIEVFV
110 120 130 140 150
HEDEAKDDKE LDWLAKRRAE EHAENVYYLL FKPEYLTRMA GKGLRQGFED

AGPARE
Length:156
Mass (Da):17,495
Last modified:November 1, 1996 - v1
Checksum:i6D65112C6B1320F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99185.1.
PIRiG64447.
RefSeqiWP_010870697.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99185; AAB99185; MJ_1184.
GeneIDi1452082.
KEGGimja:MJ_1184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99185.1.
PIRiG64447.
RefSeqiWP_010870697.1. NC_000909.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B98X-ray2.30A/B/C/D/E1-156[»]
2B99X-ray2.22A/B/C/D/E1-156[»]
4Y7JX-ray4.10A/B/C/D/E1-156[»]
4Y7KX-ray3.50A/B/C/D/E2-156[»]
5IM5X-ray3.70A/B/C/D/E/F/G/H/I/J/K/M/O/Q/S1-156[»]
ProteinModelPortaliQ58584.
SMRiQ58584.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1184.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99185; AAB99185; MJ_1184.
GeneIDi1452082.
KEGGimja:MJ_1184.

Phylogenomic databases

eggNOGiarCOG01322. Archaea.
COG1731. LUCA.
InParanoidiQ58584.
KOiK00793.
OMAiGIVDTTF.
PhylomeDBiQ58584.

Enzyme and pathway databases

UniPathwayiUPA00275; UER00405.
BioCyciMetaCyc:MONOMER-14602.
BRENDAi2.5.1.9. 3260.

Miscellaneous databases

EvolutionaryTraceiQ58584.

Family and domain databases

CDDicd09210. Riboflavin_synthase_archaeal. 1 hit.
Gene3Di3.40.50.960. 1 hit.
InterProiIPR002180. DMRL_synthase.
IPR006399. Ribfl_synth_arc.
[Graphical view]
PfamiPF00885. DMRL_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF015750. Ribfl_synth_arc. 1 hit.
SUPFAMiSSF52121. SSF52121. 1 hit.
TIGRFAMsiTIGR01506. ribC_arch. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRISC_METJA
AccessioniPrimary (citable) accession number: Q58584
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.