Reviewed, UniProtKB/Swiss-Prot Q58571 (FWDC_METJA)

Names and origin

Protein names

Recommended name:
    Tungsten-containing formylmethanofuran dehydrogenase 2 subunit C
    EC=1.2.99.5
Alternative name(s):
    Tungsten-containing formylmethanofuran dehydrogenase II subunit C

Gene names

Name:	fwdC
Ordered Locus Names:	MJ1171

Organism

Methanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP]

Taxonomic identifier

2190 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible oxidation of CO2 and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile By similarity.
Catalytic activity	Formylmethanofuran + H2O + acceptor = CO2 + methanofuran + reduced acceptor.
Cofactor	Tungsten By similarity.
Pathway	One-carbon metabolism; methanogenesis from CO(2); 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3.
Subunit structure	This enzyme is composed of six subunits fwdA, fwdC, fwdD, fwdE, fwdF and fwdG By similarity.
Sequence similarities	Belongs to the fwdC/fmdC family.

Ontologies

Keywords
Biological process	Methanogenesis
Domain	Repeat
Ligand	Tungsten
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	formylmethanofuran dehydrogenase activity Inferred from electronic annotation. Source: EC transition metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Tungsten-containing formylmethanofuran dehydrogenase 2 subunit C		PRO_0000144194
Regions
	Repeat	78 – 90	13	1
	Repeat	97 – 109	13	2
	Repeat	116 – 128	13	3
	Repeat	142 – 154	13	4
	Repeat	161 – 173	13	5
	Repeat	180 – 192	13	6
	Repeat	199 – 211	13	7
	Region	78 – 211	134	7 X 13 AA repeats of [GW]-X-X-[MQ]-X-X-G-X-[IL]-X-[IV]-X-G
	Compositional bias	187 – 190	4	Poly-Ile

Sequences

	Sequence		Length	Mass (Da)
	Q58571-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B34219D170D9C1AD	FASTA	273	29,461
	10 20 30 40 50 60 MKELILTLQK EIIVPVEMDK VLPEVIENMS LEEIKNIELV QGRKRIKVAD IFDVELNDIE 70 80 90 100 110 120 GEPRIVIKNS SPKLKYIGSK MTKGEIVVEG DAGMYVGAEM KGGKIVVNGN AESWAGQNMK 130 140 150 160 170 180 GGELLIKGNA GDYVGSAYRG DWRGMSGGTI IVEGNAGNEI GEFMSKGLIH IKGNVGIMAG 190 200 210 220 230 240 IHQNGGIIII DGDVDVRVGG EMKAGAIVVY GKVEEILPSF KFEGIVENPV IKLSKKDAGT 250 260 270 PIAGTFYKFS GDYVYNKPKG QLYISVDSNP DLI

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L77117 Genomic DNA. Translation: AAB99173.1.
PIR	B64446.
RefSeq	NP_248165.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1452069.
GenomeReviews	Gene locus MJ1171 in contig L77117_GR.
KEGG	mja:MJ1171.
NMPDR	fig|243232.1.peg.1202.
TIGR	MJ1171.
Phylogenomic databases
HOGENOM	Q58571.
OMA	YVGSAYR.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_1171-MON.
BRENDA	1.2.99.5. 256362.
Family and domain databases
InterPro	IPR017550. Formylmethanofuran_DH_suC. IPR002489. Glu_synthase_C. [Graphical view]
Gene3D	G3DSA:2.160.20.60. Glu_synthase_C. 1 hit.
Pfam	PF01493. GXGXG. 1 hit. [Graphical view]
TIGRFAMs	TIGR03122. one_C_dehyd_C. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FWDC_METJA

Accession

Primary (citable) accession number: Q58571

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	November 3, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)