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Q58546

- G3P_METJA

UniProt

Q58546 - G3P_METJA

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Protein

Glyceraldehyde-3-phosphate dehydrogenase

Gene

gap

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei114 – 1141NAD; via amide nitrogenBy similarity
Active sitei144 – 1441NucleophileBy similarity
Binding sitei172 – 1721NADBy similarity
Binding sitei307 – 3071NAD; via carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 132NADBy similarity

GO - Molecular functioni

  1. glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity Source: UniProtKB-EC
  2. glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity Source: UniProtKB-HAMAP
  3. NAD binding Source: InterPro
  4. NADP binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00109; UER00184.

Names & Taxonomyi

Protein namesi
Recommended name:
Glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.59)
Short name:
GAPDH
Alternative name(s):
NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase
Gene namesi
Name:gap
Ordered Locus Names:MJ1146
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Glyceraldehyde-3-phosphate dehydrogenasePRO_0000145723Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi243232.MJ1146.

Structurei

Secondary structure

1
343
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86
Helixi12 – 2312
Beta strandi24 – 3613
Helixi39 – 468
Beta strandi51 – 555
Helixi58 – 669
Helixi75 – 773
Helixi79 – 813
Beta strandi83 – 875
Helixi93 – 1008
Turni101 – 1066
Beta strandi108 – 1114
Helixi117 – 1193
Beta strandi120 – 1245
Turni126 – 1283
Helixi130 – 1334
Beta strandi137 – 1415
Helixi144 – 15714
Beta strandi160 – 17415
Beta strandi188 – 1958
Helixi198 – 2058
Helixi207 – 2093
Beta strandi212 – 22110
Beta strandi226 – 23611
Helixi240 – 24910
Beta strandi253 – 2564
Helixi258 – 2603
Helixi265 – 27511
Helixi278 – 2803
Beta strandi284 – 2885
Helixi289 – 2913
Beta strandi293 – 2953
Beta strandi298 – 3058
Turni307 – 3115
Helixi312 – 32211
Helixi329 – 34012

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YYYX-ray1.85A/B1-343[»]
ProteinModelPortaliQ58546.
SMRiQ58546. Positions 2-343.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58546.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni143 – 1453Glyceraldehyde 3-phosphate bindingBy similarity
Regioni198 – 1992Glyceraldehyde 3-phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0057.
InParanoidiQ58546.
KOiK00150.
OMAiVTVPSHH.
PhylomeDBiQ58546.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00559. G3P_dehdrog_arch.
InterProiIPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006436. Glyceraldehyde-3-P_DH_2_arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000149. GAP_DH. 1 hit.
SMARTiSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01546. GAPDH-II_archae. 1 hit.
PROSITEiPS00071. GAPDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58546-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAKVLINGY GSIGKRVADA VSMQDDMEVI GVTKTKPDFE ARLAVEKGYK
60 70 80 90 100
LFVAIPDNER VKLFEDAGIP VEGTILDIIE DADIVVDGAP KKIGKQNLEN
110 120 130 140 150
IYKPHKVKAI LQGGEKAKDV EDNFNALWSY NRCYGKDYVR VVSCNTTGLC
160 170 180 190 200
RILYAINSIA DIKKARIVLV RRAADPNDDK TGPVNAITPN PVTVPSHHGP
210 220 230 240 250
DVVSVVPEFE GKILTSAVIV PTTLMHMHTL MVEVDGDVSR DDILEAIKKT
260 270 280 290 300
PRIITVRAED GFSSTAKIIE YGRDLGRLRY DINELVVWEE SINVLENEIF
310 320 330 340
LMQAVHQESI VIPENIDCIR AMLQMEEDNF KSIEKTNKAM GIQ
Length:343
Mass (Da):38,102
Last modified:November 1, 1996 - v1
Checksum:i81EB5810A9C838C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99147.1.
PIRiA64443.
RefSeqiNP_248138.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99147; AAB99147; MJ_1146.
GeneIDi1452042.
KEGGimja:MJ_1146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99147.1 .
PIRi A64443.
RefSeqi NP_248138.1. NC_000909.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YYY X-ray 1.85 A/B 1-343 [» ]
ProteinModelPortali Q58546.
SMRi Q58546. Positions 2-343.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ1146.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB99147 ; AAB99147 ; MJ_1146 .
GeneIDi 1452042.
KEGGi mja:MJ_1146.

Phylogenomic databases

eggNOGi COG0057.
InParanoidi Q58546.
KOi K00150.
OMAi VTVPSHH.
PhylomeDBi Q58546.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00184 .

Miscellaneous databases

EvolutionaryTracei Q58546.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00559. G3P_dehdrog_arch.
InterProi IPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006436. Glyceraldehyde-3-P_DH_2_arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000149. GAP_DH. 1 hit.
SMARTi SM00846. Gp_dh_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01546. GAPDH-II_archae. 1 hit.
PROSITEi PS00071. GAPDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiG3P_METJA
AccessioniPrimary (citable) accession number: Q58546
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3