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Q58546 (G3P_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glyceraldehyde-3-phosphate dehydrogenase

Short name=GAPDH
EC=1.2.1.59
Alternative name(s):
NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase
Gene names
Name:gap
Ordered Locus Names:MJ1146
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H. HAMAP-Rule MF_00559

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. HAMAP-Rule MF_00559

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00559

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00559.

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Glyceraldehyde-3-phosphate dehydrogenase HAMAP-Rule MF_00559
PRO_0000145723

Regions

Nucleotide binding12 – 132NAD By similarity
Region143 – 1453Glyceraldehyde 3-phosphate binding By similarity
Region198 – 1992Glyceraldehyde 3-phosphate binding By similarity

Sites

Active site1441Nucleophile By similarity
Binding site1141NAD; via amide nitrogen By similarity
Binding site1721NAD By similarity
Binding site3071NAD; via carbonyl oxygen By similarity

Secondary structure

.................................................................... 343
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q58546 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 81EB5810A9C838C5

FASTA34338,102
        10         20         30         40         50         60 
MPAKVLINGY GSIGKRVADA VSMQDDMEVI GVTKTKPDFE ARLAVEKGYK LFVAIPDNER 

        70         80         90        100        110        120 
VKLFEDAGIP VEGTILDIIE DADIVVDGAP KKIGKQNLEN IYKPHKVKAI LQGGEKAKDV 

       130        140        150        160        170        180 
EDNFNALWSY NRCYGKDYVR VVSCNTTGLC RILYAINSIA DIKKARIVLV RRAADPNDDK 

       190        200        210        220        230        240 
TGPVNAITPN PVTVPSHHGP DVVSVVPEFE GKILTSAVIV PTTLMHMHTL MVEVDGDVSR 

       250        260        270        280        290        300 
DDILEAIKKT PRIITVRAED GFSSTAKIIE YGRDLGRLRY DINELVVWEE SINVLENEIF 

       310        320        330        340 
LMQAVHQESI VIPENIDCIR AMLQMEEDNF KSIEKTNKAM GIQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB99147.1.
PIRA64443.
RefSeqNP_248138.1. NC_000909.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YYYX-ray1.85A/B1-343[»]
ProteinModelPortalQ58546.
SMRQ58546. Positions 2-343.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ1146.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB99147; AAB99147; MJ_1146.
GeneID1452042.
KEGGmja:MJ_1146.

Phylogenomic databases

eggNOGCOG0057.
KOK00150.
OMAVTVPSHH.
PhylomeDBQ58546.

Enzyme and pathway databases

UniPathwayUPA00109; UER00184.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00559. G3P_dehdrog_arch.
InterProIPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006436. Glyceraldehyde-3-P_DH_2_arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000149. GAP_DH. 1 hit.
SMARTSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01546. GAPDH-II_archae. 1 hit.
PROSITEPS00071. GAPDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ58546.

Entry information

Entry nameG3P_METJA
AccessionPrimary (citable) accession number: Q58546
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names