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Q58546

- G3P_METJA

UniProt

Q58546 - G3P_METJA

Protein

Glyceraldehyde-3-phosphate dehydrogenase

Gene

gap

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei114 – 1141NAD; via amide nitrogenBy similarity
    Active sitei144 – 1441NucleophileBy similarity
    Binding sitei172 – 1721NADBy similarity
    Binding sitei307 – 3071NAD; via carbonyl oxygenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 132NADBy similarity

    GO - Molecular functioni

    1. glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity Source: UniProtKB-EC
    2. glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity Source: UniProtKB-HAMAP
    3. NAD binding Source: InterPro
    4. NADP binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00184.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.59)
    Short name:
    GAPDH
    Alternative name(s):
    NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase
    Gene namesi
    Name:gap
    Ordered Locus Names:MJ1146
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Glyceraldehyde-3-phosphate dehydrogenasePRO_0000145723Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi243232.MJ1146.

    Structurei

    Secondary structure

    1
    343
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 86
    Helixi12 – 2312
    Beta strandi24 – 3613
    Helixi39 – 468
    Beta strandi51 – 555
    Helixi58 – 669
    Helixi75 – 773
    Helixi79 – 813
    Beta strandi83 – 875
    Helixi93 – 1008
    Turni101 – 1066
    Beta strandi108 – 1114
    Helixi117 – 1193
    Beta strandi120 – 1245
    Turni126 – 1283
    Helixi130 – 1334
    Beta strandi137 – 1415
    Helixi144 – 15714
    Beta strandi160 – 17415
    Beta strandi188 – 1958
    Helixi198 – 2058
    Helixi207 – 2093
    Beta strandi212 – 22110
    Beta strandi226 – 23611
    Helixi240 – 24910
    Beta strandi253 – 2564
    Helixi258 – 2603
    Helixi265 – 27511
    Helixi278 – 2803
    Beta strandi284 – 2885
    Helixi289 – 2913
    Beta strandi293 – 2953
    Beta strandi298 – 3058
    Turni307 – 3115
    Helixi312 – 32211
    Helixi329 – 34012

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YYYX-ray1.85A/B1-343[»]
    ProteinModelPortaliQ58546.
    SMRiQ58546. Positions 2-343.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ58546.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni143 – 1453Glyceraldehyde 3-phosphate bindingBy similarity
    Regioni198 – 1992Glyceraldehyde 3-phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0057.
    KOiK00150.
    OMAiVTVPSHH.
    PhylomeDBiQ58546.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00559. G3P_dehdrog_arch.
    InterProiIPR020831. GlycerAld/Erythrose_P_DH.
    IPR020830. GlycerAld_3-P_DH_AS.
    IPR020829. GlycerAld_3-P_DH_cat.
    IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
    IPR006436. Glyceraldehyde-3-P_DH_2_arc.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02800. Gp_dh_C. 1 hit.
    PF00044. Gp_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000149. GAP_DH. 1 hit.
    SMARTiSM00846. Gp_dh_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01546. GAPDH-II_archae. 1 hit.
    PROSITEiPS00071. GAPDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q58546-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAKVLINGY GSIGKRVADA VSMQDDMEVI GVTKTKPDFE ARLAVEKGYK    50
    LFVAIPDNER VKLFEDAGIP VEGTILDIIE DADIVVDGAP KKIGKQNLEN 100
    IYKPHKVKAI LQGGEKAKDV EDNFNALWSY NRCYGKDYVR VVSCNTTGLC 150
    RILYAINSIA DIKKARIVLV RRAADPNDDK TGPVNAITPN PVTVPSHHGP 200
    DVVSVVPEFE GKILTSAVIV PTTLMHMHTL MVEVDGDVSR DDILEAIKKT 250
    PRIITVRAED GFSSTAKIIE YGRDLGRLRY DINELVVWEE SINVLENEIF 300
    LMQAVHQESI VIPENIDCIR AMLQMEEDNF KSIEKTNKAM GIQ 343
    Length:343
    Mass (Da):38,102
    Last modified:November 1, 1996 - v1
    Checksum:i81EB5810A9C838C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99147.1.
    PIRiA64443.
    RefSeqiNP_248138.1. NC_000909.1.
    WP_010870657.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB99147; AAB99147; MJ_1146.
    GeneIDi1452042.
    KEGGimja:MJ_1146.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99147.1 .
    PIRi A64443.
    RefSeqi NP_248138.1. NC_000909.1.
    WP_010870657.1. NC_000909.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YYY X-ray 1.85 A/B 1-343 [» ]
    ProteinModelPortali Q58546.
    SMRi Q58546. Positions 2-343.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ1146.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB99147 ; AAB99147 ; MJ_1146 .
    GeneIDi 1452042.
    KEGGi mja:MJ_1146.

    Phylogenomic databases

    eggNOGi COG0057.
    KOi K00150.
    OMAi VTVPSHH.
    PhylomeDBi Q58546.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00184 .

    Miscellaneous databases

    EvolutionaryTracei Q58546.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00559. G3P_dehdrog_arch.
    InterProi IPR020831. GlycerAld/Erythrose_P_DH.
    IPR020830. GlycerAld_3-P_DH_AS.
    IPR020829. GlycerAld_3-P_DH_cat.
    IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
    IPR006436. Glyceraldehyde-3-P_DH_2_arc.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02800. Gp_dh_C. 1 hit.
    PF00044. Gp_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000149. GAP_DH. 1 hit.
    SMARTi SM00846. Gp_dh_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01546. GAPDH-II_archae. 1 hit.
    PROSITEi PS00071. GAPDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

    Entry informationi

    Entry nameiG3P_METJA
    AccessioniPrimary (citable) accession number: Q58546
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3