Q58543 (MSMJL_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Large-conductance mechanosensitive channel MscMJLR

Gene names

Ordered Locus Names:

MJ1143

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus › Methanocaldococcus jannaschii

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Large-conductance mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Selective for cations. Rectifies with voltage. Ref.2
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.2.
Sequence similarities	Belongs to the MscS (TC 1.A.23) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ion channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Large-conductance mechanosensitive channel MscMJLR		PRO_0000110254
Regions
	Transmembrane	20 – 40	21	Helical; Potential
	Transmembrane	65 – 85	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Transmembrane	137 – 157	21	Helical; Potential
	Transmembrane	177 – 197	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q58543 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A6339C3C8AC4D68E	FASTA	361	40,683
	10 20 30 40 50 60 MTITQMISEI LMHNTVYNYI LSLISIILFI VIGKYANALI ERLADKLHKK SGIELDELLI 70 80 90 100 110 120 RALSLPVAIA IILSGFYFGV NFLYLLPSLK TAVNEGILTA FILCVVVFFD RFLNELVERY 130 140 150 160 170 180 LALTISKKTK KDVDDQIVVL TKKLVRLVVW VVGLLLILSN LGYDIKTLLA GLGIGGLAVA 190 200 210 220 230 240 LASQNLVSNL IAGLIILTDK PFKIGNWITF SGGSGIVEDI GIRSTKIRAT DNSIIVVPNS 250 260 270 280 290 300 KLIDEIIQNV PSKNKWKVST TIGVTYNTPV EKIRKAEEII KNILLEHPNV EDEPITVYFK 310 320 330 340 350 360 EFGDWSLNIQ VVYYIKNSRY NGYQKYISTI NEVNLKIKEE FDRKGIEFAF PTYTLYLKRD D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
[2]	"Structural and functional differences between two homologous mechanosensitive channels of Methanococcus jannaschii." Kloda A., Martinac B. EMBO J. 20:1888-1896(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS A MECHANOSENSITIVE CHANNEL, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB99143.1.
PIR	F64442.
RefSeq	NP_248135.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q58543.
ModBase	Search...
Protein-protein interaction databases
STRING	243232.MJ1143.
Protein family/group databases
TCDB	1.A.23.4.1. small conductance mechanosensitive ion channel (MscS) family.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB99143; AAB99143; MJ_1143.
GeneID	1452039.
KEGG	mja:MJ_1143.
Phylogenomic databases
eggNOG	COG0668.
KO	K16052.
OMA	FGFGAQN.
ProtClustDB	CLSK876099.
Family and domain databases
InterPro	IPR010920. LSM_dom. IPR011066. MscC_channel_C. IPR006685. MscS_channel. IPR006686. MscS_channel_CS. IPR011014. MscS_channel_TM-2. [Graphical view]
Pfam	PF00924. MS_channel. 1 hit. [Graphical view]
SUPFAM	SSF82689. MscC_channel_C. 1 hit. SSF82861. MscS_transmembr. 1 hit. SSF50182. Sm_like_riboprot. 1 hit.
PROSITE	PS01246. UPF0003. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSMJL_METJA

Accession

Primary (citable) accession number: Q58543

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program