UniProtKB - Q58542 (ARSA_METJA)
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Protein
Putative arsenical pump-driving ATPase
Gene
MJ1142
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Functioni
Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).By similarity
Catalytic activityi
ATP + H2O + arsenite(In) = ADP + phosphate + arsenite(Out).
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 33 – 40 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATPase-coupled arsenite transmembrane transporter activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
GO - Biological processi
- response to arsenic-containing substance Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Arsenical resistance |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MJAN243232:G1GKE-1237-MONOMER |
Protein family/group databases
TCDBi | 3.A.19.1.3 the tms recognition/insertion complex (trc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Putative arsenical pump-driving ATPase (EC:3.6.3.16)Alternative name(s): Arsenical resistance ATPase Arsenite-translocating ATPase Arsenite-transporting ATPase |
Gene namesi | Ordered Locus Names:MJ1142 |
Organismi | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) |
Taxonomic identifieri | 243232 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000152257 | 1 – 349 | Putative arsenical pump-driving ATPaseAdd BLAST | 349 |
Interactioni
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
itself | 3 | EBI-7584233,EBI-7584233 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
IntActi | Q58542 5 interactors. |
MINTi | Q58542 |
STRINGi | 243232.MJ_1142 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 13 – 21 | Combined sources | 9 | |
Beta strandi | 27 – 32 | Combined sources | 6 | |
Beta strandi | 34 – 36 | Combined sources | 3 | |
Helixi | 39 – 52 | Combined sources | 14 | |
Beta strandi | 57 – 61 | Combined sources | 5 | |
Helixi | 67 – 72 | Combined sources | 6 | |
Beta strandi | 77 – 79 | Combined sources | 3 | |
Beta strandi | 87 – 93 | Combined sources | 7 | |
Helixi | 96 – 110 | Combined sources | 15 | |
Helixi | 111 – 113 | Combined sources | 3 | |
Helixi | 115 – 130 | Combined sources | 16 | |
Helixi | 134 – 148 | Combined sources | 15 | |
Beta strandi | 153 – 157 | Combined sources | 5 | |
Helixi | 165 – 170 | Combined sources | 6 | |
Helixi | 171 – 199 | Combined sources | 29 | |
Helixi | 211 – 232 | Combined sources | 22 | |
Turni | 235 – 237 | Combined sources | 3 | |
Beta strandi | 238 – 244 | Combined sources | 7 | |
Helixi | 248 – 263 | Combined sources | 16 | |
Beta strandi | 268 – 276 | Combined sources | 9 | |
Helixi | 284 – 303 | Combined sources | 20 | |
Beta strandi | 307 – 313 | Combined sources | 7 | |
Helixi | 322 – 332 | Combined sources | 11 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3UG6 | X-ray | 3.30 | A/B/C/D | 1-349 | [»] | |
3UG7 | X-ray | 2.90 | A/B/C/D | 1-349 | [»] | |
ProteinModelPortali | Q58542 | |||||
SMRi | Q58542 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the arsA ATPase family.Curated
Phylogenomic databases
eggNOGi | arCOG02849 Archaea COG0003 LUCA |
InParanoidi | Q58542 |
KOi | K01551 |
OMAi | DQIADLY |
OrthoDBi | POG093Z07OW |
PhylomeDBi | Q58542 |
Family and domain databases
CDDi | cd02035 ArsA, 1 hit |
InterProi | View protein in InterPro IPR025723 Anion-transp_ATPase-like_dom IPR016300 ATPase_ArsA/GET3 IPR027417 P-loop_NTPase |
PANTHERi | PTHR10803 PTHR10803, 1 hit |
Pfami | View protein in Pfam PF02374 ArsA_ATPase, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit |
TIGRFAMsi | TIGR00345 GET3_arsA_TRC40, 1 hit |
i Sequence
Sequence statusi: Complete.
Q58542-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSKIKDSIN SLRGITEKKL EKKDGTKYIM FGGKGGVGKT TMSAATGVYL
60 70 80 90 100
AEKGLKVVIV STDPAHSLRD IFEQEFGHEP TKVKGYDNLY VVEIDPQKAM
110 120 130 140 150
EEYKEKLKAQ IEENPFLGEM LEDQLEMAAL SPGTDESAAF DVFLKYMDSN
160 170 180 190 200
EFDVVIFDTA PTGHTLRFLG MPEVMDKYMT KLIKLRKQMS GFMKMMKKLL
210 220 230 240 250
PFGGKDEDID YDKMLEELEK MKERIVRARN ILSDPERTAF RLVVIPEEMS
260 270 280 290 300
ILESERAMKA LQKYGIPIDA VIVNQLIPED VQCDFCRARR ELQLKRLEMI
310 320 330 340
KEKFGDKVIA YVPLLRTEAK GIETLKQIAK ILYGEEEKEE QKIEQKVGQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L77117 Genomic DNA Translation: AAB99142.1 |
PIRi | E64442 |
RefSeqi | WP_010870653.1, NC_000909.1 |
Genome annotation databases
EnsemblBacteriai | AAB99142; AAB99142; MJ_1142 |
GeneIDi | 1452038 |
KEGGi | mja:MJ_1142 |
Similar proteinsi
Entry informationi
Entry namei | ARSA_METJA | |
Accessioni | Q58542Primary (citable) accession number: Q58542 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | March 28, 2018 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |