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Protein

Putative arsenical pump-driving ATPase

Gene

MJ1142

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).By similarity

Catalytic activityi

ATP + H2O + arsenite(In) = ADP + phosphate + arsenite(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 40ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arsenical resistance

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative arsenical pump-driving ATPase (EC:3.6.3.16)
Alternative name(s):
Arsenical resistance ATPase
Arsenite-translocating ATPase
Arsenite-transporting ATPase
Gene namesi
Ordered Locus Names:MJ1142
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001522571 – 349Putative arsenical pump-driving ATPaseAdd BLAST349

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-7584233,EBI-7584233

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

IntActiQ58542. 5 interactors.
MINTiMINT-8378538.
STRINGi243232.MJ_1142.

Structurei

Secondary structure

1349
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 21Combined sources9
Beta strandi27 – 32Combined sources6
Beta strandi34 – 36Combined sources3
Helixi39 – 52Combined sources14
Beta strandi57 – 61Combined sources5
Helixi67 – 72Combined sources6
Beta strandi77 – 79Combined sources3
Beta strandi87 – 93Combined sources7
Helixi96 – 110Combined sources15
Helixi111 – 113Combined sources3
Helixi115 – 130Combined sources16
Helixi134 – 148Combined sources15
Beta strandi153 – 157Combined sources5
Helixi165 – 170Combined sources6
Helixi171 – 199Combined sources29
Helixi211 – 232Combined sources22
Turni235 – 237Combined sources3
Beta strandi238 – 244Combined sources7
Helixi248 – 263Combined sources16
Beta strandi268 – 276Combined sources9
Helixi284 – 303Combined sources20
Beta strandi307 – 313Combined sources7
Helixi322 – 332Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UG6X-ray3.30A/B/C/D1-349[»]
3UG7X-ray2.90A/B/C/D1-349[»]
ProteinModelPortaliQ58542.
SMRiQ58542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arsA ATPase family.Curated

Phylogenomic databases

eggNOGiarCOG02849. Archaea.
COG0003. LUCA.
InParanoidiQ58542.
KOiK01551.
OMAiYEIDTHN.
PhylomeDBiQ58542.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR025723. Anion-transp_ATPase-like_dom.
IPR016300. ATPase_ArsA/GET3.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10803. PTHR10803. 1 hit.
PfamiPF02374. ArsA_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00345. GET3_arsA_TRC40. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKIKDSIN SLRGITEKKL EKKDGTKYIM FGGKGGVGKT TMSAATGVYL
60 70 80 90 100
AEKGLKVVIV STDPAHSLRD IFEQEFGHEP TKVKGYDNLY VVEIDPQKAM
110 120 130 140 150
EEYKEKLKAQ IEENPFLGEM LEDQLEMAAL SPGTDESAAF DVFLKYMDSN
160 170 180 190 200
EFDVVIFDTA PTGHTLRFLG MPEVMDKYMT KLIKLRKQMS GFMKMMKKLL
210 220 230 240 250
PFGGKDEDID YDKMLEELEK MKERIVRARN ILSDPERTAF RLVVIPEEMS
260 270 280 290 300
ILESERAMKA LQKYGIPIDA VIVNQLIPED VQCDFCRARR ELQLKRLEMI
310 320 330 340
KEKFGDKVIA YVPLLRTEAK GIETLKQIAK ILYGEEEKEE QKIEQKVGQ
Length:349
Mass (Da):39,919
Last modified:November 1, 1996 - v1
Checksum:i00041F603DFDD5A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99142.1.
PIRiE64442.
RefSeqiWP_010870653.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99142; AAB99142; MJ_1142.
GeneIDi1452038.
KEGGimja:MJ_1142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99142.1.
PIRiE64442.
RefSeqiWP_010870653.1. NC_000909.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UG6X-ray3.30A/B/C/D1-349[»]
3UG7X-ray2.90A/B/C/D1-349[»]
ProteinModelPortaliQ58542.
SMRiQ58542.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ58542. 5 interactors.
MINTiMINT-8378538.
STRINGi243232.MJ_1142.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99142; AAB99142; MJ_1142.
GeneIDi1452038.
KEGGimja:MJ_1142.

Phylogenomic databases

eggNOGiarCOG02849. Archaea.
COG0003. LUCA.
InParanoidiQ58542.
KOiK01551.
OMAiYEIDTHN.
PhylomeDBiQ58542.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR025723. Anion-transp_ATPase-like_dom.
IPR016300. ATPase_ArsA/GET3.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10803. PTHR10803. 1 hit.
PfamiPF02374. ArsA_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00345. GET3_arsA_TRC40. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARSA_METJA
AccessioniPrimary (citable) accession number: Q58542
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.