MJ1142

Functionⁱ

Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).By similarity

Catalytic activityⁱ

ATP + H₂O + arsenite(In) = ADP + phosphate + arsenite(Out).

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	33 – 40	ATPSequence analysis		8

GO - Molecular functionⁱ

ATPase-coupled arsenite transmembrane transporter activity Source: UniProtKB-EC
ATP binding Source: UniProtKB-KW
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 22124326

Complete GO annotation...

GO - Biological processⁱ

response to arsenic-containing substance Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Arsenical resistance
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Putative arsenical pump-driving ATPase (EC:3.6.3.16) Alternative name(s): Arsenical resistance ATPase Arsenite-translocating ATPase Arsenite-transporting ATPase
Gene namesⁱ	Ordered Locus Names:MJ1142
Organismⁱ	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifierⁱ	243232 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus › Methanocaldococcus jannaschii
Proteomesⁱ	UP000000805 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000152257	1 – 349	Putative arsenical pump-driving ATPaseAdd BLAST		349

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		3	EBI-7584233,EBI-7584233

With

Entry

#Exp.

IntAct

Notes

itself

3

EBI-7584233,EBI-7584233

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 22124326

Complete GO annotation...

Protein-protein interaction databases

IntActⁱ	Q58542. 5 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-8378538.
STRINGⁱ	243232.MJ_1142.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	13 – 21	Combined sources	9
Beta strandⁱ	27 – 32	Combined sources	6
Beta strandⁱ	34 – 36	Combined sources	3
Helixⁱ	39 – 52	Combined sources	14
Beta strandⁱ	57 – 61	Combined sources	5
Helixⁱ	67 – 72	Combined sources	6
Beta strandⁱ	77 – 79	Combined sources	3
Beta strandⁱ	87 – 93	Combined sources	7
Helixⁱ	96 – 110	Combined sources	15
Helixⁱ	111 – 113	Combined sources	3
Helixⁱ	115 – 130	Combined sources	16
Helixⁱ	134 – 148	Combined sources	15
Beta strandⁱ	153 – 157	Combined sources	5
Helixⁱ	165 – 170	Combined sources	6
Helixⁱ	171 – 199	Combined sources	29
Helixⁱ	211 – 232	Combined sources	22
Turnⁱ	235 – 237	Combined sources	3
Beta strandⁱ	238 – 244	Combined sources	7
Helixⁱ	248 – 263	Combined sources	16
Beta strandⁱ	268 – 276	Combined sources	9
Helixⁱ	284 – 303	Combined sources	20
Beta strandⁱ	307 – 313	Combined sources	7
Helixⁱ	322 – 332	Combined sources	11

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3UG6	X-ray	3.30	A/B/C/D	1-349	[»]
	3UG7	X-ray	2.90	A/B/C/D	1-349	[»]
ProteinModelPortalⁱ	Q58542.
SMRⁱ	Q58542.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the arsA ATPase family.Curated

Phylogenomic databases

eggNOGⁱ	arCOG02849. Archaea. COG0003. LUCA.
InParanoidⁱ	Q58542.
KEGG Orthology (KO) More...KOⁱ	K01551.
OMAⁱ	DQIADLY.
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z07OW.
PhylomeDBⁱ	Q58542.

Family and domain databases

InterProⁱ	View protein in InterPro IPR025723. Anion-transp_ATPase-like_dom. IPR016300. ATPase_ArsA/GET3. IPR027417. P-loop_NTPase.
PANTHERⁱ	PTHR10803. PTHR10803. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02374. ArsA_ATPase. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR00345. GET3_arsA_TRC40. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q58542-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLSKIKDSIN SLRGITEKKL EKKDGTKYIM FGGKGGVGKT TMSAATGVYL 
        60         70         80         90        100
AEKGLKVVIV STDPAHSLRD IFEQEFGHEP TKVKGYDNLY VVEIDPQKAM 
       110        120        130        140        150
EEYKEKLKAQ IEENPFLGEM LEDQLEMAAL SPGTDESAAF DVFLKYMDSN 
       160        170        180        190        200
EFDVVIFDTA PTGHTLRFLG MPEVMDKYMT KLIKLRKQMS GFMKMMKKLL 
       210        220        230        240        250
PFGGKDEDID YDKMLEELEK MKERIVRARN ILSDPERTAF RLVVIPEEMS 
       260        270        280        290        300
ILESERAMKA LQKYGIPIDA VIVNQLIPED VQCDFCRARR ELQLKRLEMI 
       310        320        330        340 
KEKFGDKVIA YVPLLRTEAK GIETLKQIAK ILYGEEEKEE QKIEQKVGQ

Length:349

Mass (Da):39,919

Last modified:November 1, 1996 - v1

Checksum:ⁱ00041F603DFDD5A3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L77117 Genomic DNA. Translation: AAB99142.1.
PIRⁱ	E64442.
NCBI Reference Sequences More...RefSeqⁱ	WP_010870653.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaⁱ	AAB99142; AAB99142; MJ_1142.
GeneIDⁱ	1452038.
KEGGⁱ	mja:MJ_1142.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L77117 Genomic DNA. Translation: AAB99142.1.
PIRⁱ	E64442.
NCBI Reference Sequences More...RefSeqⁱ	WP_010870653.1. NC_000909.1.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3UG6	X-ray	3.30	A/B/C/D	1-349	[»]
	3UG7	X-ray	2.90	A/B/C/D	1-349	[»]
ProteinModelPortalⁱ	Q58542.
SMRⁱ	Q58542.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q58542. 5 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-8378538.
STRINGⁱ	243232.MJ_1142.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAB99142; AAB99142; MJ_1142.
GeneIDⁱ	1452038.
KEGGⁱ	mja:MJ_1142.

Phylogenomic databases

eggNOGⁱ	arCOG02849. Archaea. COG0003. LUCA.
InParanoidⁱ	Q58542.
KEGG Orthology (KO) More...KOⁱ	K01551.
OMAⁱ	DQIADLY.
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z07OW.
PhylomeDBⁱ	Q58542.

Family and domain databases

InterProⁱ	View protein in InterPro IPR025723. Anion-transp_ATPase-like_dom. IPR016300. ATPase_ArsA/GET3. IPR027417. P-loop_NTPase.
PANTHERⁱ	PTHR10803. PTHR10803. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02374. ArsA_ATPase. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR00345. GET3_arsA_TRC40. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARSA_METJA
Accessionⁱ	Q58542Primary (citable) accession number: Q58542
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1996
	Last modified:	June 7, 2017
	This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Methanococcus jannaschii
Methanococcus jannaschii: entries and gene names
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q58542 (ARSA_METJA)

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Putative arsenical pump-driving ATPase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ