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Q58539

- RNP3_METJA

UniProt

Q58539 - RNP3_METJA

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Protein

Ribonuclease P protein component 3

Gene
rnp3, MJ1139
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.3 Publications

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA 5'-leader removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein component 3 (EC:3.1.26.5)
Short name:
RNase P component 3
Alternative name(s):
Rpp30
Gene namesi
Name:rnp3
Ordered Locus Names:MJ1139
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. ribonuclease P complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Ribonuclease P protein component 3UniRule annotationPRO_0000140039Add
BLAST

Interactioni

Subunit structurei

Consists of a catalytic RNA component and at least 4-5 protein subunits. Forms a subcomplex with Rnp2 which stimulates the catalytic RNA.3 Publications

Protein-protein interaction databases

STRINGi243232.MJ1139.

Structurei

3D structure databases

ProteinModelPortaliQ58539.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1603.
KOiK03539.
OMAiVAIELNF.
PhylomeDBiQ58539.

Family and domain databases

HAMAPiMF_00756. RNase_P_3.
InterProiIPR016195. Pol/histidinol_Pase-like.
IPR023539. RNase_P_comp-3_arc.
IPR002738. RNase_P_p30.
[Graphical view]
PfamiPF01876. RNase_P_p30. 1 hit.
[Graphical view]
SUPFAMiSSF89550. SSF89550. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58539-1 [UniParc]FASTAAdd to Basket

« Hide

MRIDINRIEK EEDIKLLKEL KWNGFVFYQY DDEFSKDRYE EVKAIAESYK    50
LKVYSGVKIK TESSKQLRDK VKKFRNKCHI ILIEGGVLKI NRAAVELHDV 100
DILSTPELGR KDSGIDHVLA RLASNHRVAI ELNFKTLLNK DGYERARTLL 150
FFRNNLKLAK KFDVPVVIST DAENKYQIKN PYDLRAFLNT LVEPLYAKKI 200
METAYKICDF RDYLMRDNVV RYGVEIIKEE KE 232
Length:232
Mass (Da):27,346
Last modified:November 1, 1996 - v1
Checksum:i5490A2447A7E897B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99146.1.
PIRiB64442.
RefSeqiNP_248131.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99146; AAB99146; MJ_1139.
GeneIDi1452035.
KEGGimja:MJ_1139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99146.1 .
PIRi B64442.
RefSeqi NP_248131.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58539.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ1139.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB99146 ; AAB99146 ; MJ_1139 .
GeneIDi 1452035.
KEGGi mja:MJ_1139.

Phylogenomic databases

eggNOGi COG1603.
KOi K03539.
OMAi VAIELNF.
PhylomeDBi Q58539.

Family and domain databases

HAMAPi MF_00756. RNase_P_3.
InterProi IPR016195. Pol/histidinol_Pase-like.
IPR023539. RNase_P_comp-3_arc.
IPR002738. RNase_P_p30.
[Graphical view ]
Pfami PF01876. RNase_P_p30. 1 hit.
[Graphical view ]
SUPFAMi SSF89550. SSF89550. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. "Studies on Methanocaldococcus jannaschii RNase P reveal insights into the roles of RNA and protein cofactors in RNase P catalysis."
    Pulukkunat D.K., Gopalan V.
    Nucleic Acids Res. 36:4172-4180(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RNP2, SUBUNIT.
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  3. "Cooperative RNP assembly: complementary rescue of structural defects by protein and RNA subunits of archaeal RNase P."
    Chen W.Y., Xu Y., Cho I.M., Oruganti S.V., Foster M.P., Gopalan V.
    J. Mol. Biol. 411:368-383(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RNP2, SUBUNIT.
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  4. "Fidelity of tRNA 5'-maturation: a possible basis for the functional dependence of archaeal and eukaryal RNase P on multiple protein cofactors."
    Chen W.Y., Singh D., Lai L.B., Stiffler M.A., Lai H.D., Foster M.P., Gopalan V.
    Nucleic Acids Res. 40:4666-4680(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RNP2, SUBUNIT.

Entry informationi

Entry nameiRNP3_METJA
AccessioniPrimary (citable) accession number: Q58539
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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