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Q58539 (RNP3_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease P protein component 3

Short name=RNase P component 3
EC=3.1.26.5
Alternative name(s):
Rpp30
Gene names
Name:rnp3
Ordered Locus Names:MJ1139
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Ref.2 Ref.3 Ref.4

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP-Rule MF_00756

Subunit structure

Consists of a catalytic RNA component and at least 4-5 protein subunits. Forms a subcomplex with Rnp2 which stimulates the catalytic RNA. Ref.2 Ref.3 Ref.4

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00756.

Sequence similarities

Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtRNA 5'-leader removal

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

ribonuclease P complex

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionribonuclease P activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 232232Ribonuclease P protein component 3 HAMAP-Rule MF_00756
PRO_0000140039

Sequences

Sequence LengthMass (Da)Tools
Q58539 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 5490A2447A7E897B

FASTA23227,346
        10         20         30         40         50         60 
MRIDINRIEK EEDIKLLKEL KWNGFVFYQY DDEFSKDRYE EVKAIAESYK LKVYSGVKIK 

        70         80         90        100        110        120 
TESSKQLRDK VKKFRNKCHI ILIEGGVLKI NRAAVELHDV DILSTPELGR KDSGIDHVLA 

       130        140        150        160        170        180 
RLASNHRVAI ELNFKTLLNK DGYERARTLL FFRNNLKLAK KFDVPVVIST DAENKYQIKN 

       190        200        210        220        230 
PYDLRAFLNT LVEPLYAKKI METAYKICDF RDYLMRDNVV RYGVEIIKEE KE 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii."
Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. expand/collapse author list , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
Science 273:1058-1073(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
[2]"Studies on Methanocaldococcus jannaschii RNase P reveal insights into the roles of RNA and protein cofactors in RNase P catalysis."
Pulukkunat D.K., Gopalan V.
Nucleic Acids Res. 36:4172-4180(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH RNP2, SUBUNIT.
Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
[3]"Cooperative RNP assembly: complementary rescue of structural defects by protein and RNA subunits of archaeal RNase P."
Chen W.Y., Xu Y., Cho I.M., Oruganti S.V., Foster M.P., Gopalan V.
J. Mol. Biol. 411:368-383(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH RNP2, SUBUNIT.
Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
[4]"Fidelity of tRNA 5'-maturation: a possible basis for the functional dependence of archaeal and eukaryal RNase P on multiple protein cofactors."
Chen W.Y., Singh D., Lai L.B., Stiffler M.A., Lai H.D., Foster M.P., Gopalan V.
Nucleic Acids Res. 40:4666-4680(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH RNP2, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB99146.1.
PIRB64442.
RefSeqNP_248131.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ58539.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ1139.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB99146; AAB99146; MJ_1139.
GeneID1452035.
KEGGmja:MJ_1139.

Phylogenomic databases

eggNOGCOG1603.
KOK03539.
OMAVAIELNF.
PhylomeDBQ58539.

Family and domain databases

HAMAPMF_00756. RNase_P_3.
InterProIPR016195. Pol/histidinol_Pase-like.
IPR023539. RNase_P_comp-3_arc.
IPR002738. RNase_P_p30.
[Graphical view]
PfamPF01876. RNase_P_p30. 1 hit.
[Graphical view]
SUPFAMSSF89550. SSF89550. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRNP3_METJA
AccessionPrimary (citable) accession number: Q58539
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names