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Q58539

- RNP3_METJA

UniProt

Q58539 - RNP3_METJA

Protein

Ribonuclease P protein component 3

Gene

rnp3

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.3 PublicationsUniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tRNA 5'-leader removal Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    tRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein component 3UniRule annotation (EC:3.1.26.5UniRule annotation)
    Short name:
    RNase P component 3UniRule annotation
    Alternative name(s):
    Rpp30UniRule annotation
    Gene namesi
    Name:rnp3UniRule annotation
    Ordered Locus Names:MJ1139
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. ribonuclease P complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 232232Ribonuclease P protein component 3PRO_0000140039Add
    BLAST

    Interactioni

    Subunit structurei

    Consists of a catalytic RNA component and at least 4-5 protein subunits. Forms a subcomplex with Rnp2 which stimulates the catalytic RNA.3 PublicationsUniRule annotation

    Protein-protein interaction databases

    STRINGi243232.MJ1139.

    Structurei

    3D structure databases

    ProteinModelPortaliQ58539.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic/archaeal RNase P protein component 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1603.
    KOiK03539.
    OMAiVAIELNF.
    PhylomeDBiQ58539.

    Family and domain databases

    HAMAPiMF_00756. RNase_P_3.
    InterProiIPR016195. Pol/histidinol_Pase-like.
    IPR023539. RNase_P_comp-3_arc.
    IPR002738. RNase_P_p30.
    [Graphical view]
    PfamiPF01876. RNase_P_p30. 1 hit.
    [Graphical view]
    SUPFAMiSSF89550. SSF89550. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q58539-1 [UniParc]FASTAAdd to Basket

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    MRIDINRIEK EEDIKLLKEL KWNGFVFYQY DDEFSKDRYE EVKAIAESYK    50
    LKVYSGVKIK TESSKQLRDK VKKFRNKCHI ILIEGGVLKI NRAAVELHDV 100
    DILSTPELGR KDSGIDHVLA RLASNHRVAI ELNFKTLLNK DGYERARTLL 150
    FFRNNLKLAK KFDVPVVIST DAENKYQIKN PYDLRAFLNT LVEPLYAKKI 200
    METAYKICDF RDYLMRDNVV RYGVEIIKEE KE 232
    Length:232
    Mass (Da):27,346
    Last modified:November 1, 1996 - v1
    Checksum:i5490A2447A7E897B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99146.1.
    PIRiB64442.
    RefSeqiNP_248131.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB99146; AAB99146; MJ_1139.
    GeneIDi1452035.
    KEGGimja:MJ_1139.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99146.1 .
    PIRi B64442.
    RefSeqi NP_248131.1. NC_000909.1.

    3D structure databases

    ProteinModelPortali Q58539.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ1139.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB99146 ; AAB99146 ; MJ_1139 .
    GeneIDi 1452035.
    KEGGi mja:MJ_1139.

    Phylogenomic databases

    eggNOGi COG1603.
    KOi K03539.
    OMAi VAIELNF.
    PhylomeDBi Q58539.

    Family and domain databases

    HAMAPi MF_00756. RNase_P_3.
    InterProi IPR016195. Pol/histidinol_Pase-like.
    IPR023539. RNase_P_comp-3_arc.
    IPR002738. RNase_P_p30.
    [Graphical view ]
    Pfami PF01876. RNase_P_p30. 1 hit.
    [Graphical view ]
    SUPFAMi SSF89550. SSF89550. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
    2. "Studies on Methanocaldococcus jannaschii RNase P reveal insights into the roles of RNA and protein cofactors in RNase P catalysis."
      Pulukkunat D.K., Gopalan V.
      Nucleic Acids Res. 36:4172-4180(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RNP2, SUBUNIT.
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
    3. "Cooperative RNP assembly: complementary rescue of structural defects by protein and RNA subunits of archaeal RNase P."
      Chen W.Y., Xu Y., Cho I.M., Oruganti S.V., Foster M.P., Gopalan V.
      J. Mol. Biol. 411:368-383(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RNP2, SUBUNIT.
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
    4. "Fidelity of tRNA 5'-maturation: a possible basis for the functional dependence of archaeal and eukaryal RNase P on multiple protein cofactors."
      Chen W.Y., Singh D., Lai L.B., Stiffler M.A., Lai H.D., Foster M.P., Gopalan V.
      Nucleic Acids Res. 40:4666-4680(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RNP2, SUBUNIT.

    Entry informationi

    Entry nameiRNP3_METJA
    AccessioniPrimary (citable) accession number: Q58539
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3