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Q58524 (HELS_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative ski2-type helicase

EC=3.6.4.-

Cleaved into the following chain:

  1. Endonuclease PI-MjaHel
    EC=3.1.-.-
    Alternative name(s):
    Mja Hel intein
    Mja Pep3 intein
Gene names
Ordered Locus Names:MJ1124
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length1195 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Post-translational modification

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation Potential. HAMAP-Rule MF_00442

Sequence similarities

Belongs to the helicase family. SKI2 subfamily.

Contains 1 DOD-type homing endonuclease domain.

Contains 1 helicase ATP-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Putative ski2-type helicase, 1st part Potential
PRO_0000013299
Chain338 – 838501Endonuclease PI-MjaHel Potential
PRO_0000013300
Chain839 – 1195357Putative ski2-type helicase, 2nd part Potential
PRO_0000013301

Regions

Domain26 – 196171Helicase ATP-binding
Domain451 – 584134DOD-type homing endonuclease
Nucleotide binding39 – 468ATP By similarity
Motif143 – 1464DEAH box HAMAP-Rule MF_00442
Compositional bias137 – 1426Poly-Val HAMAP-Rule MF_00442

Sequences

Sequence LengthMass (Da)Tools
Q58524 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 87C9CF1A87EFB52D

FASTA1,195138,674
        10         20         30         40         50         60 
MDKILEILKD FGIVELRPPQ KKALERGLLD KNKNFLISIP TASGKTLIGE MALINHLLDG 

        70         80         90        100        110        120 
NKNPTNKKGI FIVPLKALAS EKYEEFKSKY ERYGLRIALS IGDYDEDEDL SKYHLIITTA 

       130        140        150        160        170        180 
EKLDSLWRHK IDWINDVSVV VVDEIHLIND ETRGGTLEIL LTKLKEFNVQ IIGLSATIGN 

       190        200        210        220        230        240 
PDELAEWLNA ELIVDDWRPV ELKKGIYKNE AIEFINGEIR EIKAVDNNDI YNLVVDCVKE 

       250        260        270        280        290        300 
GGCCLVFCNT KRNAVNEAKK LNLKKFLTEE EKIRLKEIAE EILSILEPPT EMCKTLAECI 

       310        320        330        340        350        360 
LNGSAFHHAG LTYQHRKIVE DAFRKRLIKV ICCTPTLCLN ANTEILQESG FRKITELNKD 

       370        380        390        400        410        420 
EKVFALCGKE IKPVDGWKVH KTPQHEYNIV VKTVNGLEIT TTPNHIFLVK ENGSLKEKEA 

       430        440        450        460        470        480 
KDLKVGDYVA TVDRIRVKEK DIDLSNGDLY FIGYFIGDGY TGVIEKNTLK ATPDLAFNPK 

       490        500        510        520        530        540 
YPPNFDDSEL HKKYFLKCRI SKGVAHYIYS KKLRKIFNKL NMLTKDNKNI DAFCNLPLDK 

       550        560        570        580        590        600 
LAYLIAGLFD SDGYIYLNRK NIEFYSISEK LVEQLQFVLL RFGIHSSIRK KKTKTMVSPT 

       610        620        630        640        650        660 
NGKEYKCKDI YVLTIRDFMS IKRFYENIPL RHEEKRRKLE EIIKNKEIGQ IPSEFVALRF 

       670        680        690        700        710        720 
TPIAKIWCDC GFSVDLTMFK PRTKRQRELN KKRVKLLFEL LDGKKLITNY KEYYSKRKNP 

       730        740        750        760        770        780 
YFDFIVREKI NGNNYYSLNE KGRVLMSLLN KHIKDKENLE EMYNFLVNLE KCPICGKPIH 

       790        800        810        820        830        840 
KEMRYSWKKE CYDGDIYWDR IKEIKKIKVN DKYAYDIELP DDGSNSHYIV ANGFIVHNSA 

       850        860        870        880        890        900 
GLNLPCRRAI VKDLTRFTNK GMRYIPIMEI QQCIGRAGRP GLDPYGEGII VAKNDRDYLR 

       910        920        930        940        950        960 
AYQALTQKPE PIYSKLSNQA VLRTQLLGLI ATGEIRDEYD LEWFIRNTFY AHQYGNLREV 

       970        980        990       1000       1010       1020 
AKNINEVIRF LEENEFIIDF MPTELGKRVS ELYIDPLSAK FIIDGLEEME NEEEIYYLYL 

      1030       1040       1050       1060       1070       1080 
ISKTLEMMPN LRVYNSEELN LIDEMDSLGI KSFEIEDLEA FKTAKMLYDW INEVPEDEIL 

      1090       1100       1110       1120       1130       1140 
KRYKIEPGIL RYKVENAVWI MHALKEIAKL IGKSSDIPEK LEIRLEYGAK EDIIELLSIK 

      1150       1160       1170       1180       1190 
YIGRVRARKL YNAGIRSIED IINNPSKVAS IIGEKIAKKI LDELGVKFGQ QKLSF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB99126.1.
PIRC64440.
RefSeqNP_248116.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ58524.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ1124.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB99126; AAB99126; MJ_1124.
GeneID1452020.
KEGGmja:MJ_1124.

Phylogenomic databases

eggNOGCOG1372.
KOK03726.
OMACLNANTE.
ProtClustDBCLSK796742.

Family and domain databases

Gene3D3.10.28.10. 1 hit.
3.40.50.300. 5 hits.
HAMAPMF_00442. Helicase_ski2.
InterProIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR022965. Helicase_ski2.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027434. Homing_endonucl.
IPR006142. INTEIN.
IPR004042. Intein_endonuc.
IPR006141. Intein_splice_site.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00270. DEAD. 1 hit.
PF14528. LAGLIDADG_3. 1 hit.
[Graphical view]
PRINTSPR00379. INTEIN.
SMARTSM00487. DEXDc. 1 hit.
SM00278. HhH1. 2 hits.
SM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 3 hits.
SSF55608. SSF55608. 1 hit.
TIGRFAMsTIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS50818. INTEIN_C_TER. 1 hit.
PS50819. INTEIN_ENDONUCLEASE. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHELS_METJA
AccessionPrimary (citable) accession number: Q58524
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

Intein-containing proteins

List of intein-containing protein entries