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Protein

ATP-dependent DNA helicase Hel308

Gene

hel308

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 46ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Endonuclease, Helicase, Hydrolase, Nuclease
Biological processDNA damage, DNA repair, Intron homing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMJAN243232:G1GKE-1219-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent DNA helicase Hel308UniRule annotation (EC:3.6.4.12UniRule annotation)
Cleaved into the following chain:
Alternative name(s):
Mja Hel intein
Mja Pep3 intein
Gene namesi
Name:hel308UniRule annotation
Ordered Locus Names:MJ1124
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000132991 – 337ATP-dependent DNA helicase Hel308, 1st partSequence analysisAdd BLAST337
ChainiPRO_0000013300338 – 838Endonuclease PI-MjaHelSequence analysisAdd BLAST501
ChainiPRO_0000013301839 – 1195ATP-dependent DNA helicase Hel308, 2nd partSequence analysisAdd BLAST357

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.Curated

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Proteomic databases

PRIDEiQ58524

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi243232.MJ_1124

Structurei

3D structure databases

ProteinModelPortaliQ58524
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 196Helicase ATP-bindingUniRule annotationAdd BLAST171
Domaini451 – 584DOD-type homing endonucleaseAdd BLAST134

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi143 – 146DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi137 – 142Poly-Val6

Sequence similaritiesi

Belongs to the helicase family. Hel308 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00553 Archaea
arCOG03157 Archaea
COG1204 LUCA
COG1372 LUCA
InParanoidiQ58524
KOiK03726
OMAiCLNANTE
OrthoDBiPOG093Z00MB

Family and domain databases

Gene3Di3.10.28.10, 1 hit
HAMAPiMF_00442 Helicase_Hel308, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR022965 Helicase_Hel308
IPR003586 Hint_dom_C
IPR003587 Hint_dom_N
IPR036844 Hint_dom_sf
IPR027434 Homing_endonucl
IPR006142 INTEIN
IPR030934 Intein_C
IPR004042 Intein_endonuc
IPR006141 Intein_N
IPR004860 LAGLIDADG_2
IPR027417 P-loop_NTPase
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF14528 LAGLIDADG_3, 1 hit
PRINTSiPR00379 INTEIN
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00305 HintC, 1 hit
SM00306 HintN, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF51294 SSF51294, 2 hits
SSF52540 SSF52540, 3 hits
SSF55608 SSF55608, 1 hit
TIGRFAMsiTIGR01443 intein_Cterm, 1 hit
TIGR01445 intein_Nterm, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS50818 INTEIN_C_TER, 1 hit
PS50819 INTEIN_ENDONUCLEASE, 1 hit
PS50817 INTEIN_N_TER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58524-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKILEILKD FGIVELRPPQ KKALERGLLD KNKNFLISIP TASGKTLIGE
60 70 80 90 100
MALINHLLDG NKNPTNKKGI FIVPLKALAS EKYEEFKSKY ERYGLRIALS
110 120 130 140 150
IGDYDEDEDL SKYHLIITTA EKLDSLWRHK IDWINDVSVV VVDEIHLIND
160 170 180 190 200
ETRGGTLEIL LTKLKEFNVQ IIGLSATIGN PDELAEWLNA ELIVDDWRPV
210 220 230 240 250
ELKKGIYKNE AIEFINGEIR EIKAVDNNDI YNLVVDCVKE GGCCLVFCNT
260 270 280 290 300
KRNAVNEAKK LNLKKFLTEE EKIRLKEIAE EILSILEPPT EMCKTLAECI
310 320 330 340 350
LNGSAFHHAG LTYQHRKIVE DAFRKRLIKV ICCTPTLCLN ANTEILQESG
360 370 380 390 400
FRKITELNKD EKVFALCGKE IKPVDGWKVH KTPQHEYNIV VKTVNGLEIT
410 420 430 440 450
TTPNHIFLVK ENGSLKEKEA KDLKVGDYVA TVDRIRVKEK DIDLSNGDLY
460 470 480 490 500
FIGYFIGDGY TGVIEKNTLK ATPDLAFNPK YPPNFDDSEL HKKYFLKCRI
510 520 530 540 550
SKGVAHYIYS KKLRKIFNKL NMLTKDNKNI DAFCNLPLDK LAYLIAGLFD
560 570 580 590 600
SDGYIYLNRK NIEFYSISEK LVEQLQFVLL RFGIHSSIRK KKTKTMVSPT
610 620 630 640 650
NGKEYKCKDI YVLTIRDFMS IKRFYENIPL RHEEKRRKLE EIIKNKEIGQ
660 670 680 690 700
IPSEFVALRF TPIAKIWCDC GFSVDLTMFK PRTKRQRELN KKRVKLLFEL
710 720 730 740 750
LDGKKLITNY KEYYSKRKNP YFDFIVREKI NGNNYYSLNE KGRVLMSLLN
760 770 780 790 800
KHIKDKENLE EMYNFLVNLE KCPICGKPIH KEMRYSWKKE CYDGDIYWDR
810 820 830 840 850
IKEIKKIKVN DKYAYDIELP DDGSNSHYIV ANGFIVHNSA GLNLPCRRAI
860 870 880 890 900
VKDLTRFTNK GMRYIPIMEI QQCIGRAGRP GLDPYGEGII VAKNDRDYLR
910 920 930 940 950
AYQALTQKPE PIYSKLSNQA VLRTQLLGLI ATGEIRDEYD LEWFIRNTFY
960 970 980 990 1000
AHQYGNLREV AKNINEVIRF LEENEFIIDF MPTELGKRVS ELYIDPLSAK
1010 1020 1030 1040 1050
FIIDGLEEME NEEEIYYLYL ISKTLEMMPN LRVYNSEELN LIDEMDSLGI
1060 1070 1080 1090 1100
KSFEIEDLEA FKTAKMLYDW INEVPEDEIL KRYKIEPGIL RYKVENAVWI
1110 1120 1130 1140 1150
MHALKEIAKL IGKSSDIPEK LEIRLEYGAK EDIIELLSIK YIGRVRARKL
1160 1170 1180 1190
YNAGIRSIED IINNPSKVAS IIGEKIAKKI LDELGVKFGQ QKLSF
Length:1,195
Mass (Da):138,674
Last modified:November 1, 1996 - v1
Checksum:i87C9CF1A87EFB52D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB99126.1
PIRiC64440
RefSeqiWP_010870635.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB99126; AAB99126; MJ_1124
GeneIDi1452020
KEGGimja:MJ_1124

Entry informationi

Entry nameiHELS_METJA
AccessioniPrimary (citable) accession number: Q58524
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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