Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q58516 (ASNH1_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative asparagine synthetase [glutamine-hydrolyzing] 1

EC=6.3.5.4
Gene names
Ordered Locus Names:MJ1116
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length541 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate.

Pathway

Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.

Sequence similarities

Belongs to the asparagine synthetase family.

Contains 1 glutamine amidotransferase type-2 domain.

Sequence caution

The sequence AAB99117.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 541540Putative asparagine synthetase [glutamine-hydrolyzing] 1
PRO_0000056937

Regions

Domain2 – 213212Glutamine amidotransferase type-2
Nucleotide binding363 – 3642ATP By similarity
Region68 – 725Glutamine binding By similarity
Region92 – 943Glutamine binding By similarity

Sites

Active site21For GATase activity By similarity
Binding site1161Glutamine By similarity
Binding site2891ATP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q58516 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 9B3FA64E39A957BB

FASTA54162,655
        10         20         30         40         50         60 
MCSISGIIVK DNQISAKYSI DMMKILKHRG RDNSGLLLDD EVIYFNDFED VEDLEEEMIG 

        70         80         90        100        110        120 
NLSLAHNRLA IVGRYGVQPI PNEDETIWLV CNGEIYNYIE LREYLKQNHE FRTDSDNEVI 

       130        140        150        160        170        180 
IHLYEEEKLE ELDGDYAFAI YDKSKNVVRL ARDMFGVKPL FYVDRDKYFA FASERKALWH 

       190        200        210        220        230        240 
LLINIDGCER DLDELNSKIK TLKPNSQLIY YLDDNRFEII EGFKKLELNY MKERSYEEAK 

       250        260        270        280        290        300 
EYLDRALKNS VLKRVRGLDK VGIICSGGVD SSLIAKLASL YCEVILYAVG TENSEDLIYA 

       310        320        330        340        350        360 
ERLAKDLNLK LRKKIISEEE YEEYVFKVAK AIDEVDLMKI GVGIPIYVAS EMANEDGLKV 

       370        380        390        400        410        420 
VLSGQGADEL FGGYARHERI YRERGEEELK KELLKDVYNL YKVNLERDDH CTMANGVELR 

       430        440        450        460        470        480 
VPFLDEEVVE IALSIPIEYK MSELSNRPYA ESNISLKSEP INGLKNTNLN IKCVRSVRKK 

       490        500        510        520        530        540 
ILRDVASQYL PDYIAYRPKK AAQYGSGGEK MIYKVAKKYG FSKKRINEFL DMLKRKIVSE 


F 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB99117.1. Different initiation.
PIRC64439.
RefSeqNP_248108.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ58516.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ1116.

Protein family/group databases

MEROPSC44.976.

Protocols and materials databases

DNASU1452012.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB99117; AAB99117; MJ_1116.
GeneID1452012.
KEGGmja:MJ_1116.

Phylogenomic databases

eggNOGCOG0367.
KOK01953.
OMAIYVASEM.
PhylomeDBQ58516.

Enzyme and pathway databases

UniPathwayUPA00134; UER00195.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.60.20.10. 1 hit.
InterProIPR006426. Asn_synth_AEB.
IPR001962. Asn_synthase.
IPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00733. Asn_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF001589. Asn_synthetase_glu-h. 1 hit.
SUPFAMSSF56235. SSF56235. 1 hit.
TIGRFAMsTIGR01536. asn_synth_AEB. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASNH1_METJA
AccessionPrimary (citable) accession number: Q58516
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names