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Q58516

- ASNH1_METJA

UniProt

Q58516 - ASNH1_METJA

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Protein
Putative asparagine synthetase [glutamine-hydrolyzing] 1
Gene
MJ1116
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21For GATase activity By similarity
Binding sitei116 – 1161Glutamine By similarity
Binding sitei289 – 2891ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi363 – 3642ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. asparagine synthase (glutamine-hydrolyzing) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. L-asparagine biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Asparagine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00134; UER00195.

Protein family/group databases

MEROPSiC44.976.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative asparagine synthetase [glutamine-hydrolyzing] 1 (EC:6.3.5.4)
Gene namesi
Ordered Locus Names:MJ1116
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 541540Putative asparagine synthetase [glutamine-hydrolyzing] 1
PRO_0000056937Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ1116.

Structurei

3D structure databases

ProteinModelPortaliQ58516.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 213212Glutamine amidotransferase type-2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 725Glutamine binding By similarity
Regioni92 – 943Glutamine binding By similarity

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0367.
KOiK01953.
OMAiIYVASEM.
PhylomeDBiQ58516.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.60.20.10. 1 hit.
InterProiIPR006426. Asn_synth_AEB.
IPR001962. Asn_synthase.
IPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00733. Asn_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001589. Asn_synthetase_glu-h. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01536. asn_synth_AEB. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58516-1 [UniParc]FASTAAdd to Basket

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MCSISGIIVK DNQISAKYSI DMMKILKHRG RDNSGLLLDD EVIYFNDFED    50
VEDLEEEMIG NLSLAHNRLA IVGRYGVQPI PNEDETIWLV CNGEIYNYIE 100
LREYLKQNHE FRTDSDNEVI IHLYEEEKLE ELDGDYAFAI YDKSKNVVRL 150
ARDMFGVKPL FYVDRDKYFA FASERKALWH LLINIDGCER DLDELNSKIK 200
TLKPNSQLIY YLDDNRFEII EGFKKLELNY MKERSYEEAK EYLDRALKNS 250
VLKRVRGLDK VGIICSGGVD SSLIAKLASL YCEVILYAVG TENSEDLIYA 300
ERLAKDLNLK LRKKIISEEE YEEYVFKVAK AIDEVDLMKI GVGIPIYVAS 350
EMANEDGLKV VLSGQGADEL FGGYARHERI YRERGEEELK KELLKDVYNL 400
YKVNLERDDH CTMANGVELR VPFLDEEVVE IALSIPIEYK MSELSNRPYA 450
ESNISLKSEP INGLKNTNLN IKCVRSVRKK ILRDVASQYL PDYIAYRPKK 500
AAQYGSGGEK MIYKVAKKYG FSKKRINEFL DMLKRKIVSE F 541
Length:541
Mass (Da):62,655
Last modified:November 1, 1997 - v1
Checksum:i9B3FA64E39A957BB
GO

Sequence cautioni

The sequence AAB99117.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99117.1. Different initiation.
PIRiC64439.
RefSeqiNP_248108.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99117; AAB99117; MJ_1116.
GeneIDi1452012.
KEGGimja:MJ_1116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99117.1 . Different initiation.
PIRi C64439.
RefSeqi NP_248108.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58516.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243232.MJ1116.

Protein family/group databases

MEROPSi C44.976.

Protocols and materials databases

DNASUi 1452012.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB99117 ; AAB99117 ; MJ_1116 .
GeneIDi 1452012.
KEGGi mja:MJ_1116.

Phylogenomic databases

eggNOGi COG0367.
KOi K01953.
OMAi IYVASEM.
PhylomeDBi Q58516.

Enzyme and pathway databases

UniPathwayi UPA00134 ; UER00195 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.60.20.10. 1 hit.
InterProi IPR006426. Asn_synth_AEB.
IPR001962. Asn_synthase.
IPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00733. Asn_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001589. Asn_synthetase_glu-h. 1 hit.
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01536. asn_synth_AEB. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiASNH1_METJA
AccessioniPrimary (citable) accession number: Q58516
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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