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Protein

Trk system potassium uptake protein TrkA homolog

Gene

trkA

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of a potassium transport system.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30NAD1 Publication1
Binding sitei51NAD1 Publication1
Binding sitei97NAD; shared with dimeric partner1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 11NAD1 Publication5
Nucleotide bindingi73 – 74NAD1 Publication2

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

NAD, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Trk system potassium uptake protein TrkA homolog
Short name:
K(+)-uptake protein TrkA homolog
Gene namesi
Name:trkA
Ordered Locus Names:MJ1105
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001487251 – 218Trk system potassium uptake protein TrkA homologAdd BLAST218

Interactioni

Subunit structurei

Homotetramer. Dimer of dimers.1 Publication

Protein-protein interaction databases

STRINGi243232.MJ_1105.

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Helixi10 – 21Combined sources12
Beta strandi25 – 31Combined sources7
Helixi33 – 42Combined sources10
Beta strandi44 – 50Combined sources7
Helixi55 – 60Combined sources6
Turni61 – 65Combined sources5
Beta strandi67 – 71Combined sources5
Helixi76 – 88Combined sources13
Beta strandi94 – 97Combined sources4
Helixi103 – 109Combined sources7
Beta strandi113 – 116Combined sources4
Helixi118 – 130Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LSSX-ray2.30A/B/C/D1-136[»]
ProteinModelPortaliQ58505.
SMRiQ58505.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58505.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 124RCK N-terminalPROSITE-ProRule annotationAdd BLAST123
Domaini136 – 217RCK C-terminalPROSITE-ProRule annotationAdd BLAST82

Domaini

The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport.1 Publication

Sequence similaritiesi

Contains 1 RCK C-terminal domain.PROSITE-ProRule annotation
Contains 1 RCK N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG01957. Archaea.
COG0569. LUCA.
InParanoidiQ58505.
KOiK03499.
OMAiFNDSWGV.
PhylomeDBiQ58505.

Family and domain databases

Gene3Di3.30.70.1450. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR006036. K_uptake_TrkA.
IPR016040. NAD(P)-bd_dom.
IPR006037. RCK_C.
IPR003148. RCK_N.
[Graphical view]
PfamiPF02080. TrkA_C. 1 hit.
PF02254. TrkA_N. 1 hit.
[Graphical view]
PRINTSiPR00335. KUPTAKETRKA.
SUPFAMiSSF116726. SSF116726. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS51202. RCK_C. 1 hit.
PS51201. RCK_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58505-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYIIIAGIGR VGYTLAKSLS EKGHDIVLID IDKDICKKAS AEIDALVING
60 70 80 90 100
DCTKIKTLED AGIEDADMYI AVTGKEEVNL MSSLLAKSYG INKTIARISE
110 120 130 140 150
IEYKDVFERL GVDVVVSPEL IAANYIEKLI ERPGILDLAI VGRGEAEILE
160 170 180 190 200
FIIPEKAKVV NKKIKELGRP QDYLIIAIYD GDELKIPSGD TELKSGDRVL
210
VLVKKDAADA IRKMFLEE
Length:218
Mass (Da):23,996
Last modified:November 1, 1996 - v1
Checksum:i28CFD33E8791E0CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99108.1.
PIRiH64437.
RefSeqiWP_010870617.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99108; AAB99108; MJ_1105.
GeneIDi1452002.
KEGGimja:MJ_1105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99108.1.
PIRiH64437.
RefSeqiWP_010870617.1. NC_000909.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LSSX-ray2.30A/B/C/D1-136[»]
ProteinModelPortaliQ58505.
SMRiQ58505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99108; AAB99108; MJ_1105.
GeneIDi1452002.
KEGGimja:MJ_1105.

Phylogenomic databases

eggNOGiarCOG01957. Archaea.
COG0569. LUCA.
InParanoidiQ58505.
KOiK03499.
OMAiFNDSWGV.
PhylomeDBiQ58505.

Miscellaneous databases

EvolutionaryTraceiQ58505.

Family and domain databases

Gene3Di3.30.70.1450. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR006036. K_uptake_TrkA.
IPR016040. NAD(P)-bd_dom.
IPR006037. RCK_C.
IPR003148. RCK_N.
[Graphical view]
PfamiPF02080. TrkA_C. 1 hit.
PF02254. TrkA_N. 1 hit.
[Graphical view]
PRINTSiPR00335. KUPTAKETRKA.
SUPFAMiSSF116726. SSF116726. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS51202. RCK_C. 1 hit.
PS51201. RCK_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRKA_METJA
AccessioniPrimary (citable) accession number: Q58505
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.