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Protein

Trk system potassium uptake protein TrkA homolog

Gene

trkA

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of a potassium transport system.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301NAD1 Publication
Binding sitei51 – 511NAD1 Publication
Binding sitei97 – 971NAD; shared with dimeric partner1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 115NAD1 Publication
Nucleotide bindingi73 – 742NAD1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

NAD, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Trk system potassium uptake protein TrkA homolog
Short name:
K(+)-uptake protein TrkA homolog
Gene namesi
Name:trkA
Ordered Locus Names:MJ1105
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Trk system potassium uptake protein TrkA homologPRO_0000148725Add
BLAST

Interactioni

Subunit structurei

Homotetramer. Dimer of dimers.1 Publication

Protein-protein interaction databases

STRINGi243232.MJ_1105.

Structurei

Secondary structure

1
218
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65Combined sources
Helixi10 – 2112Combined sources
Beta strandi25 – 317Combined sources
Helixi33 – 4210Combined sources
Beta strandi44 – 507Combined sources
Helixi55 – 606Combined sources
Turni61 – 655Combined sources
Beta strandi67 – 715Combined sources
Helixi76 – 8813Combined sources
Beta strandi94 – 974Combined sources
Helixi103 – 1097Combined sources
Beta strandi113 – 1164Combined sources
Helixi118 – 13013Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LSSX-ray2.30A/B/C/D1-136[»]
ProteinModelPortaliQ58505.
SMRiQ58505. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58505.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 124123RCK N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini136 – 21782RCK C-terminalPROSITE-ProRule annotationAdd
BLAST

Domaini

The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport.1 Publication

Sequence similaritiesi

Contains 1 RCK C-terminal domain.PROSITE-ProRule annotation
Contains 1 RCK N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG01957. Archaea.
COG0569. LUCA.
InParanoidiQ58505.
KOiK03499.
OMAiFNDSWGV.
PhylomeDBiQ58505.

Family and domain databases

Gene3Di3.30.70.1450. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR006036. K_uptake_TrkA.
IPR016040. NAD(P)-bd_dom.
IPR006037. RCK_C.
IPR003148. RCK_N.
[Graphical view]
PfamiPF02080. TrkA_C. 1 hit.
PF02254. TrkA_N. 1 hit.
[Graphical view]
PRINTSiPR00335. KUPTAKETRKA.
SUPFAMiSSF116726. SSF116726. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS51202. RCK_C. 1 hit.
PS51201. RCK_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58505-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYIIIAGIGR VGYTLAKSLS EKGHDIVLID IDKDICKKAS AEIDALVING
60 70 80 90 100
DCTKIKTLED AGIEDADMYI AVTGKEEVNL MSSLLAKSYG INKTIARISE
110 120 130 140 150
IEYKDVFERL GVDVVVSPEL IAANYIEKLI ERPGILDLAI VGRGEAEILE
160 170 180 190 200
FIIPEKAKVV NKKIKELGRP QDYLIIAIYD GDELKIPSGD TELKSGDRVL
210
VLVKKDAADA IRKMFLEE
Length:218
Mass (Da):23,996
Last modified:November 1, 1996 - v1
Checksum:i28CFD33E8791E0CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99108.1.
PIRiH64437.

Genome annotation databases

EnsemblBacteriaiAAB99108; AAB99108; MJ_1105.
KEGGimja:MJ_1105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99108.1.
PIRiH64437.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LSSX-ray2.30A/B/C/D1-136[»]
ProteinModelPortaliQ58505.
SMRiQ58505. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99108; AAB99108; MJ_1105.
KEGGimja:MJ_1105.

Phylogenomic databases

eggNOGiarCOG01957. Archaea.
COG0569. LUCA.
InParanoidiQ58505.
KOiK03499.
OMAiFNDSWGV.
PhylomeDBiQ58505.

Miscellaneous databases

EvolutionaryTraceiQ58505.

Family and domain databases

Gene3Di3.30.70.1450. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR006036. K_uptake_TrkA.
IPR016040. NAD(P)-bd_dom.
IPR006037. RCK_C.
IPR003148. RCK_N.
[Graphical view]
PfamiPF02080. TrkA_C. 1 hit.
PF02254. TrkA_N. 1 hit.
[Graphical view]
PRINTSiPR00335. KUPTAKETRKA.
SUPFAMiSSF116726. SSF116726. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS51202. RCK_C. 1 hit.
PS51201. RCK_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. "A mechanism of regulating transmembrane potassium flux through a ligand-mediated conformational switch."
    Roosild T.P., Miller S., Booth I.R., Choe S.
    Cell 109:781-791(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 1-136 IN COMPLEX WITH NAD, DOMAIN, SUBUNIT.

Entry informationi

Entry nameiTRKA_METJA
AccessioniPrimary (citable) accession number: Q58505
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: December 9, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.