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Q58504

- KHSE_METJA

UniProt

Q58504 - KHSE_METJA

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Protein

Homoserine kinase

Gene

thrB

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.By similarity

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi86 – 9611ATPSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. homoserine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14633.
SABIO-RKQ58504.
UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinase (EC:2.7.1.39)
Short name:
HK
Short name:
HSK
Gene namesi
Name:thrB
Ordered Locus Names:MJ1104
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Homoserine kinasePRO_0000156641Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ1104.

Structurei

Secondary structure

1
296
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 1211
Helixi15 – 173
Turni18 – 203
Beta strandi21 – 4727
Turni55 – 573
Helixi59 – 7012
Beta strandi76 – 827
Beta strandi89 – 913
Helixi93 – 10816
Helixi115 – 13016
Helixi138 – 1436
Beta strandi145 – 1517
Turni152 – 1554
Beta strandi156 – 1605
Beta strandi168 – 1714
Helixi179 – 1846
Beta strandi188 – 1914
Helixi192 – 21019
Helixi214 – 2218
Helixi228 – 2325
Helixi238 – 2458
Helixi246 – 2483
Beta strandi249 – 2546
Beta strandi261 – 2655
Helixi267 – 2693
Helixi270 – 28011
Beta strandi284 – 2874
Beta strandi293 – 2953

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FWKX-ray2.10A/B/C/D1-296[»]
1FWLX-ray2.25A/B/C/D1-296[»]
1H72X-ray1.80C1-296[»]
1H73X-ray2.00A1-296[»]
1H74X-ray1.90A/B/C/D1-296[»]
ProteinModelPortaliQ58504.
SMRiQ58504. Positions 1-296.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58504.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0083.
InParanoidiQ58504.
KOiK00872.
OMAiKENIVYQ.
PhylomeDBiQ58504.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58504-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVRVKAPCT SANLGVGFDV FGLCLKEPYD VIEVEAIDDK EIIIEVDDKN
60 70 80 90 100
IPTDPDKNVA GIVAKKMIDD FNIGKGVKIT IKKGVKAGSG LGSSAASSAG
110 120 130 140 150
TAYAINELFK LNLDKLKLVD YASYGELASS GAKHADNVAP AIFGGFTMVT
160 170 180 190 200
NYEPLEVLHI PIDFKLDILI AIPNISINTK EAREILPKAV GLKDLVNNVG
210 220 230 240 250
KACGMVYALY NKDKSLFGRY MMSDKVIEPV RGKLIPNYFK IKEEVKDKVY
260 270 280 290
GITISGSGPS IIAFPKEEFI DEVENILRDY YENTIRTEVG KGVEVV
Length:296
Mass (Da):32,259
Last modified:June 1, 2001 - v2
Checksum:i49919E68F3834C78
GO

Sequence cautioni

The sequence AAB99107.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99107.1. Different initiation.
PIRiG64437.
RefSeqiNP_248097.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99107; AAB99107; MJ_1104.
GeneIDi1452001.
KEGGimja:MJ_1104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99107.1 . Different initiation.
PIRi G64437.
RefSeqi NP_248097.1. NC_000909.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FWK X-ray 2.10 A/B/C/D 1-296 [» ]
1FWL X-ray 2.25 A/B/C/D 1-296 [» ]
1H72 X-ray 1.80 C 1-296 [» ]
1H73 X-ray 2.00 A 1-296 [» ]
1H74 X-ray 1.90 A/B/C/D 1-296 [» ]
ProteinModelPortali Q58504.
SMRi Q58504. Positions 1-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ1104.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB99107 ; AAB99107 ; MJ_1104 .
GeneIDi 1452001.
KEGGi mja:MJ_1104.

Phylogenomic databases

eggNOGi COG0083.
InParanoidi Q58504.
KOi K00872.
OMAi KENIVYQ.
PhylomeDBi Q58504.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00064 .
BioCyci MetaCyc:MONOMER-14633.
SABIO-RK Q58504.

Miscellaneous databases

EvolutionaryTracei Q58504.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPi MF_00384. Homoser_kinase.
InterProi IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
Pfami PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000676. Homoser_kin. 1 hit.
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsi TIGR00191. thrB. 1 hit.
PROSITEi PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. "Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily."
    Zhou T., Daugherty M., Grishin N.V., Osterman A.L., Zhang H.
    Structure 8:1247-1257(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).

Entry informationi

Entry nameiKHSE_METJA
AccessioniPrimary (citable) accession number: Q58504
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3