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Q58504 (KHSE_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:thrB
Ordered Locus Names:MJ1104
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384

Subcellular location

Cytoplasm Potential HAMAP MF_00384.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Sequence caution

The sequence AAB99107.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

homoserine kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296Homoserine kinase HAMAP MF_00384
PRO_0000156641

Regions

Nucleotide binding86 – 9611ATP Potential

Secondary structure

1 ................................................ 296
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q58504 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: 49919E68F3834C78

FASTA29632,259
        10         20         30         40         50         60 
MKVRVKAPCT SANLGVGFDV FGLCLKEPYD VIEVEAIDDK EIIIEVDDKN IPTDPDKNVA 

        70         80         90        100        110        120 
GIVAKKMIDD FNIGKGVKIT IKKGVKAGSG LGSSAASSAG TAYAINELFK LNLDKLKLVD 

       130        140        150        160        170        180 
YASYGELASS GAKHADNVAP AIFGGFTMVT NYEPLEVLHI PIDFKLDILI AIPNISINTK 

       190        200        210        220        230        240 
EAREILPKAV GLKDLVNNVG KACGMVYALY NKDKSLFGRY MMSDKVIEPV RGKLIPNYFK 

       250        260        270        280        290 
IKEEVKDKVY GITISGSGPS IIAFPKEEFI DEVENILRDY YENTIRTEVG KGVEVV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L77117 Genomic DNA. Translation: AAB99107.1. Different initiation.
PIRG64437.
RefSeqNP_248097.1. NC_000909.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FWKX-ray2.10A/B/C/D1-296[»]
1FWLX-ray2.25A/B/C/D1-296[»]
1H72X-ray1.80C1-296[»]
1H73X-ray2.00A1-296[»]
1H74X-ray1.90A/B/C/D1-296[»]
ProteinModelPortalQ58504.
SMRQ58504. Positions 1-296.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1452001.
GenomeReviewsGene locus MJ1104 in contig L77117_GR.
KEGGmja:MJ_1104.
NMPDRfig|243232.1.peg.1134.
TIGRMJ1104.

Phylogenomic databases

HOGENOMHBG646290.
OMAGSAHADN.
ProtClustDBPRK01212.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-14633.
MJAN243232:MJ_1104-MONOMER.

Family and domain databases

HAMAPMF_00384. Homoser_kinase.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00872.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. ThrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKHSE_METJA
AccessionPrimary (citable) accession number: Q58504
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 1, 2001
Last modified: November 16, 2011
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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