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Reviewed, UniProtKB/Swiss-Prot Q58504 (KHSE_METJA)

Last modified June 16, 2009. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39
Gene names
Name: thrB
Ordered Locus Names: MJ1104
OrganismMethanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP]
Taxonomic identifier2190 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processphosphorylation

Inferred from electronic annotation. Source: InterPro

threonine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

homoserine kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296Homoserine kinase HAMAP MF_00384
PRO_0000156641

Regions

Nucleotide binding86 – 9611ATP Potential

Secondary structure

................................................ 296
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q58504-1 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: 49919E68F3834C78

FASTA29632,259
        10         20         30         40         50         60 
MKVRVKAPCT SANLGVGFDV FGLCLKEPYD VIEVEAIDDK EIIIEVDDKN IPTDPDKNVA 

        70         80         90        100        110        120 
GIVAKKMIDD FNIGKGVKIT IKKGVKAGSG LGSSAASSAG TAYAINELFK LNLDKLKLVD 

       130        140        150        160        170        180 
YASYGELASS GAKHADNVAP AIFGGFTMVT NYEPLEVLHI PIDFKLDILI AIPNISINTK 

       190        200        210        220        230        240 
EAREILPKAV GLKDLVNNVG KACGMVYALY NKDKSLFGRY MMSDKVIEPV RGKLIPNYFK 

       250        260        270        280        290 
IKEEVKDKVY GITISGSGPS IIAFPKEEFI DEVENILRDY YENTIRTEVG KGVEVV 

« Hide

Cross-references

Sequence databases

L77117 Genomic DNA. Translation: AAB99107.1. Different initiation.
PIRG64437.
RefSeqNP_248097.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1FWKX-ray2.10A/B/C/D1-296[»]
1FWLX-ray2.25A/B/C/D1-296[»]
1H72X-ray1.80C1-296[»]
1H73X-ray2.00A1-296[»]
1H74X-ray1.90A/B/C/D1-296[»]
ModBaseSearch...

Genome annotation databases

GeneID1452001.
GenomeReviewsGene locus MJ1104 in contig L77117_GR.
KEGGmja:MJ1104.
NMPDRfig|243232.1.peg.1134.
TIGRMJ1104.

Phylogenomic databases

HOGENOMQ58504.

Enzyme and pathway databases

BioCycMJAN243232:MJ_1104-MON.
BRENDA2.7.1.39. 256362.

Family and domain databases

HAMAPMF_00384.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR006203. GHMP_knse_ATP_bd_CS.
IPR000870. Homoserine_kin.
IPR014721. Ribosomal_S5_D2-type_fold.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
TIGRFAMsTIGR00191. thrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKHSE_METJA
AccessionPrimary (citable) accession number: Q58504
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 1, 2001
Last modified: June 16, 2009
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents