Homoserine kinase - Methanocaldococcus jannaschii

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Reviewed, UniProtKB/Swiss-Prot Q58504 (KHSE_METJA)

Last modified June 16, 2009. Version 72. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	MJ1104

Organism

Methanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP]

Taxonomic identifier

2190 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

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Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

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Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	phosphorylation Inferred from electronic annotation. Source: InterPro threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 296

296

Homoserine kinase HAMAP MF_00384

PRO_0000156641

Regions

Nucleotide binding

86 – 96

ATP Potential

Secondary structure

296

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q58504-1 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: 49919E68F3834C78
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FASTA

296

32,259

        10         20         30         40         50         60 
MKVRVKAPCT SANLGVGFDV FGLCLKEPYD VIEVEAIDDK EIIIEVDDKN IPTDPDKNVA 

        70         80         90        100        110        120 
GIVAKKMIDD FNIGKGVKIT IKKGVKAGSG LGSSAASSAG TAYAINELFK LNLDKLKLVD 

       130        140        150        160        170        180 
YASYGELASS GAKHADNVAP AIFGGFTMVT NYEPLEVLHI PIDFKLDILI AIPNISINTK 

       190        200        210        220        230        240 
EAREILPKAV GLKDLVNNVG KACGMVYALY NKDKSLFGRY MMSDKVIEPV RGKLIPNYFK 

       250        260        270        280        290 
IKEEVKDKVY GITISGSGPS IIAFPKEEFI DEVENILRDY YENTIRTEVG KGVEVV

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
[2]	"Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily." Zhou T., Daugherty M., Grishin N.V., Osterman A.L., Zhang H. Structure 8:1247-1257(2000) [PubMed: 11188689] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
+	Additional computationally mapped references.

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Cross-references

Sequence databases

L77117 Genomic DNA. Translation: AAB99107.1. Different initiation.

PIR

G64437.

RefSeq

NP_248097.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1FWK	X-ray	2.10	A/B/C/D	1-296	[»]
1FWL	X-ray	2.25	A/B/C/D	1-296	[»]
1H72	X-ray	1.80	C	1-296	[»]
1H73	X-ray	2.00	A	1-296	[»]
1H74	X-ray	1.90	A/B/C/D	1-296	[»]

ModBase

Search...

Genome annotation databases

GeneID

1452001.

GenomeReviews

Gene locus MJ1104 in contig L77117_GR.

KEGG

mja:MJ1104.

NMPDR

fig|243232.1.peg.1134.

TIGR

MJ1104.

Phylogenomic databases

HOGENOM

Q58504.

Enzyme and pathway databases

BioCyc

MJAN243232:MJ_1104-MON.

BRENDA

2.7.1.39. 256362.

Family and domain databases

HAMAP

MF_00384.
[Tree]

InterPro

IPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR006203. GHMP_knse_ATP_bd_CS.
IPR000870. Homoserine_kin.
IPR014721. Ribosomal_S5_D2-type_fold.
[Graphical view]

Gene3D

G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.

Pfam

PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]

PIRSF

PIRSF000676. Homoser_kin. 1 hit.

PRINTS

PR00958. HOMSERKINASE.

TIGRFAMs

TIGR00191. thrB. 1 hit.

PROSITE

PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

ProtoNet

Search...

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Entry information

Entry name

KHSE_METJA

Accession

Primary (citable) accession number: Q58504

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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