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Q58504

- KHSE_METJA

UniProt

Q58504 - KHSE_METJA

Protein

Homoserine kinase

Gene

thrB

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.By similarity

    Catalytic activityi

    ATP + L-homoserine = ADP + O-phospho-L-homoserine.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi86 – 9611ATPSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. homoserine kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-14633.
    SABIO-RKQ58504.
    UniPathwayiUPA00050; UER00064.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homoserine kinase (EC:2.7.1.39)
    Short name:
    HK
    Short name:
    HSK
    Gene namesi
    Name:thrB
    Ordered Locus Names:MJ1104
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Homoserine kinasePRO_0000156641Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243232.MJ1104.

    Structurei

    Secondary structure

    1
    296
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 1211
    Helixi15 – 173
    Turni18 – 203
    Beta strandi21 – 4727
    Turni55 – 573
    Helixi59 – 7012
    Beta strandi76 – 827
    Beta strandi89 – 913
    Helixi93 – 10816
    Helixi115 – 13016
    Helixi138 – 1436
    Beta strandi145 – 1517
    Turni152 – 1554
    Beta strandi156 – 1605
    Beta strandi168 – 1714
    Helixi179 – 1846
    Beta strandi188 – 1914
    Helixi192 – 21019
    Helixi214 – 2218
    Helixi228 – 2325
    Helixi238 – 2458
    Helixi246 – 2483
    Beta strandi249 – 2546
    Beta strandi261 – 2655
    Helixi267 – 2693
    Helixi270 – 28011
    Beta strandi284 – 2874
    Beta strandi293 – 2953

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FWKX-ray2.10A/B/C/D1-296[»]
    1FWLX-ray2.25A/B/C/D1-296[»]
    1H72X-ray1.80C1-296[»]
    1H73X-ray2.00A1-296[»]
    1H74X-ray1.90A/B/C/D1-296[»]
    ProteinModelPortaliQ58504.
    SMRiQ58504. Positions 1-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ58504.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0083.
    KOiK00872.
    OMAiKENIVYQ.
    PhylomeDBiQ58504.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPiMF_00384. Homoser_kinase.
    InterProiIPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR000870. Homoserine_kinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PfamiPF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000676. Homoser_kin. 1 hit.
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsiTIGR00191. thrB. 1 hit.
    PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q58504-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVRVKAPCT SANLGVGFDV FGLCLKEPYD VIEVEAIDDK EIIIEVDDKN    50
    IPTDPDKNVA GIVAKKMIDD FNIGKGVKIT IKKGVKAGSG LGSSAASSAG 100
    TAYAINELFK LNLDKLKLVD YASYGELASS GAKHADNVAP AIFGGFTMVT 150
    NYEPLEVLHI PIDFKLDILI AIPNISINTK EAREILPKAV GLKDLVNNVG 200
    KACGMVYALY NKDKSLFGRY MMSDKVIEPV RGKLIPNYFK IKEEVKDKVY 250
    GITISGSGPS IIAFPKEEFI DEVENILRDY YENTIRTEVG KGVEVV 296
    Length:296
    Mass (Da):32,259
    Last modified:June 1, 2001 - v2
    Checksum:i49919E68F3834C78
    GO

    Sequence cautioni

    The sequence AAB99107.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99107.1. Different initiation.
    PIRiG64437.
    RefSeqiNP_248097.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB99107; AAB99107; MJ_1104.
    GeneIDi1452001.
    KEGGimja:MJ_1104.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB99107.1 . Different initiation.
    PIRi G64437.
    RefSeqi NP_248097.1. NC_000909.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FWK X-ray 2.10 A/B/C/D 1-296 [» ]
    1FWL X-ray 2.25 A/B/C/D 1-296 [» ]
    1H72 X-ray 1.80 C 1-296 [» ]
    1H73 X-ray 2.00 A 1-296 [» ]
    1H74 X-ray 1.90 A/B/C/D 1-296 [» ]
    ProteinModelPortali Q58504.
    SMRi Q58504. Positions 1-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ1104.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB99107 ; AAB99107 ; MJ_1104 .
    GeneIDi 1452001.
    KEGGi mja:MJ_1104.

    Phylogenomic databases

    eggNOGi COG0083.
    KOi K00872.
    OMAi KENIVYQ.
    PhylomeDBi Q58504.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00064 .
    BioCyci MetaCyc:MONOMER-14633.
    SABIO-RK Q58504.

    Miscellaneous databases

    EvolutionaryTracei Q58504.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPi MF_00384. Homoser_kinase.
    InterProi IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR000870. Homoserine_kinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    Pfami PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000676. Homoser_kin. 1 hit.
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsi TIGR00191. thrB. 1 hit.
    PROSITEi PS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
    2. "Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily."
      Zhou T., Daugherty M., Grishin N.V., Osterman A.L., Zhang H.
      Structure 8:1247-1257(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).

    Entry informationi

    Entry nameiKHSE_METJA
    AccessioniPrimary (citable) accession number: Q58504
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3