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Q58502

- DUT_METJA

UniProt

Q58502 - DUT_METJA

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
dut, MJ1102
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

SABIO-RKQ58502.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
MjDUT
dUTP pyrophosphatase
Gene namesi
Name:dut
Ordered Locus Names:MJ1102
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 156155Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation
PRO_0000153638Add
BLAST

Interactioni

Subunit structurei

Homotrimer Inferred.

Protein-protein interaction databases

STRINGi243232.MJ1102.

Structurei

3D structure databases

ProteinModelPortaliQ58502.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0717.
KOiK01520.
OMAiQCGIDLR.
PhylomeDBiQ58502.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00635. dUTPase_arch.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58502-1 [UniParc]FASTAAdd to Basket

« Hide

MIIGANTSKN FFDNLEEEQI QQCGIDLRVW KIFKIEGEGV IDFSNEKRKL    50
PNYIEIFNSE KDEHIKLDRG VYIVKVADYI KIPENVAGFA YPRSSLLRMG 100
ATLYSAVHDP GYEGRPEYLM QVFNPITIYK YARIAQIVFV ECRDVKGVYE 150
GIYKGR 156
Length:156
Mass (Da):18,070
Last modified:January 23, 2007 - v4
Checksum:iAF6E28A4CF91FF3D
GO

Sequence cautioni

The sequence AAB99105.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99105.1. Different initiation.
PIRiE64437.
RefSeqiNP_248095.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99105; AAB99105; MJ_1102.
GeneIDi1451999.
KEGGimja:MJ_1102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB99105.1 . Different initiation.
PIRi E64437.
RefSeqi NP_248095.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58502.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243232.MJ1102.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB99105 ; AAB99105 ; MJ_1102 .
GeneIDi 1451999.
KEGGi mja:MJ_1102.

Phylogenomic databases

eggNOGi COG0717.
KOi K01520.
OMAi QCGIDLR.
PhylomeDBi Q58502.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
SABIO-RK Q58502.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00635. dUTPase_arch.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. "A bifunctional dCTP deaminase-dUTP nucleotidohydrolase from the hyperthermophilic archaeon Methanocaldococcus jannaschii."
    Bjoernberg O., Neuhard J., Nyman P.O.
    J. Biol. Chem. 278:20667-20672(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-10, CHARACTERIZATION.
  3. "The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase."
    Li H., Xu H., Graham D.E., White R.H.
    J. Biol. Chem. 278:11100-11106(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiDUT_METJA
AccessioniPrimary (citable) accession number: Q58502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 84 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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