ID   Q584D3_TRYB2            Unreviewed;        78 AA.
AC   Q584D3; D6XFJ0;
DT   10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2005, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   SubName: Full=Ubiquitin, putative {ECO:0000313|EMBL:AAX79072.1};
GN   Name=Tb04.1H19.1090 {ECO:0000313|EMBL:AAZ10845.1};
GN   ORFNames=Tb927.4.2540 {ECO:0000313|EMBL:AAX79072.1};
OS   Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=185431 {ECO:0000313|EMBL:AAX79072.1, ECO:0000313|Proteomes:UP000008524};
RN   [1] {ECO:0000313|EMBL:AAX79072.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX79072.1};
RA   El-Sayed N.M., Khalak H., Adams M.D.;
RL   Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAZ10845.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ10845.1};
RX   PubMed=16020724; DOI=10.1126/science.1112181;
RA   El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA   Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA   Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA   Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA   Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA   Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA   Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA   Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA   Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT   "Comparative genomics of trypanosomatid parasitic protozoa.";
RL   Science 309:404-409(2005).
RN   [3] {ECO:0000313|EMBL:AAZ10845.1, ECO:0000313|Proteomes:UP000008524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ10845.1,
RC   ECO:0000313|Proteomes:UP000008524};
RX   PubMed=16020726; DOI=10.1126/science.1112642;
RA   Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA   Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA   Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA   Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA   Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA   Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA   Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA   Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA   Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA   Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA   Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA   Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA   Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA   Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA   Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA   Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA   Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA   Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT   "The genome of the African trypanosome Trypanosoma brucei.";
RL   Science 309:416-422(2005).
RN   [4] {ECO:0000313|EMBL:AAX79072.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX79072.1};
RA   Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA   Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA   Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA   Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA   Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT   ".";
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:AAZ10845.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ10845.1};
RA   Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA   Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA   Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA   Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA   Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT   "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2
RT   through 8.";
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0007829|PDB:2LRW}
RP   STRUCTURE BY NMR.
RA   Wang R., Liao S., Wang T., Zhang J., Tu X.;
RT   "Solution structure of a ubiqutin-like protein from Trypanosoma bucei.";
RL   Submitted (APR-2012) to the PDB data bank.
RN   [7] {ECO:0007829|PDB:5GO0}
RP   STRUCTURE BY NMR.
RA   Wang R., Liao S., Zhang J., Tu X.;
RT   "Solution structure of nedd8 from Trypanosoma brucei.";
RL   Submitted (JUL-2016) to the PDB data bank.
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DR   EMBL; AC079933; AAX79072.1; -; Genomic_DNA.
DR   EMBL; CP000067; AAZ10845.1; -; Genomic_DNA.
DR   RefSeq; XP_844404.1; XM_839311.1.
DR   PDB; 2LRW; NMR; -; A=1-78.
DR   PDB; 5GO0; NMR; -; A=1-78.
DR   PDBsum; 2LRW; -.
DR   PDBsum; 5GO0; -.
DR   AlphaFoldDB; Q584D3; -.
DR   SMR; Q584D3; -.
DR   STRING; 185431.Q584D3; -.
DR   PaxDb; 5691-AAZ10845; -.
DR   GeneID; 3656780; -.
DR   KEGG; tbr:Tb927.4.2540; -.
DR   VEuPathDB; TriTrypDB:Tb927.4.2540; -.
DR   eggNOG; KOG0005; Eukaryota.
DR   InParanoid; Q584D3; -.
DR   OMA; YAGKQMA; -.
DR   OrthoDB; 158575at2759; -.
DR   Proteomes; UP000008524; Chromosome 4.
DR   GO; GO:0005929; C:cilium; IDA:GeneDB.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB.
DR   GO; GO:0005634; C:nucleus; IDA:GeneDB.
DR   GO; GO:0031386; F:protein tag activity; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR   GO; GO:0019941; P:modification-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0045116; P:protein neddylation; IBA:GO_Central.
DR   GO; GO:0030162; P:regulation of proteolysis; IBA:GO_Central.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR019956; Ubiquitin_dom.
DR   PANTHER; PTHR10666:SF173; NEDD8; 1.
DR   PANTHER; PTHR10666; UBIQUITIN; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   PRINTS; PR00348; UBIQUITIN.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:2LRW, ECO:0007829|PDB:5GO0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008524}.
FT   DOMAIN          1..77
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50053"
SQ   SEQUENCE   78 AA;  8668 MW;  AD02638DE4B17375 CRC64;
     MLLKVKTVSN KVIQITSLTD DNTIAELKGK LEESEGIPGN MIRLVYQGKQ LEDEKRLKDY
     QMSAGATFHM VVALRAGC
//