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Q58484 (AROE_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Shikimate dehydrogenase
EC=1.1.1.25
Gene names
Name:aroE
Ordered Locus Names:MJ1084
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus ›

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP-Rule MF_00222

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP-Rule MF_00222

Subunit structure

Homodimer. Ref.2

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Shikimate dehydrogenase HAMAP-Rule MF_00222
PRO_0000136060

Regions

Nucleotide binding130 – 1345NADP HAMAP-Rule MF_00222
Nucleotide binding152 – 1576NADP HAMAP-Rule MF_00222
Nucleotide binding247 – 2515NADP By similarity

Sites

Active site701Proton acceptor Potential
Binding site1061Substrate By similarity
Binding site1961NADP; via carbonyl oxygen
Binding site2001NADP
Binding site2241NADP; via carbonyl oxygen

Secondary structure

1 .................................................. 282
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q58484 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E7398E5D642F7BD1

FASTA28230,877
        10         20         30         40         50         60 
MINAKTKVIG LIGHPVEHSF SPIMHNAAFK DKGLNYVYVA FDVLPENLKY VIDGAKALGI 

        70         80         90        100        110        120 
VGFNVTIPHK IEIMKYLDEI DKDAQLIGAV NTIKIEDGKA IGYNTDGIGA RMALEEEIGR 

       130        140        150        160        170        180 
VKDKNIVIYG AGGAARAVAF ELAKDNNIII ANRTVEKAEA LAKEIAEKLN KKFGEEVKFS 

       190        200        210        220        230        240 
GLDVDLDGVD IIINATPIGM YPNIDVEPIV KAEKLREDMV VMDLIYNPLE TVLLKEAKKV 

       250        260        270        280 
NAKTINGLGM LIYQGAVAFK IWTGVEPNIE VMKNAIIDKI TK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L77117 Genomic DNA. Translation: AAB99086.1.
PIRC64435.
RefSeqNP_248077.1. NC_000909.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1NVTX-ray2.35A/B1-282[»]
ProteinModelPortalQ58484.
SMRQ58484. Positions 1-282.
ModBaseSearch...

Protein-protein interaction databases

STRING243232.MJ1084.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB99086; AAB99086; MJ_1084.
GeneID1451980.
KEGGmja:MJ_1084.

Phylogenomic databases

eggNOGCOG0169.
KOK00014.
OMAAFKIWTG.
ProtClustDBPRK00258.

Enzyme and pathway databases

UniPathwayUPA00053; UER00087.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00222. Shikimate_DH_AroE.
InterProIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
PfamPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00507. aroE. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ58484.

Entry information

Entry nameAROE_METJA
AccessionPrimary (citable) accession number: Q58484
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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