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Q58484

- AROE_METJA

UniProt

Q58484 - AROE_METJA

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Protein

Shikimate dehydrogenase

Gene

aroE

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Shikimate + NADP+ = 3-dehydroshikimate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei70 – 701Proton acceptorSequence Analysis
Binding sitei106 – 1061SubstrateBy similarity
Binding sitei196 – 1961NADP; via carbonyl oxygen1 Publication
Binding sitei200 – 2001NADP1 Publication
Binding sitei224 – 2241NADP; via carbonyl oxygen1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi130 – 1345NADP1 Publication
Nucleotide bindingi152 – 1576NADP1 Publication
Nucleotide bindingi247 – 2515NADPBy similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. shikimate 3-dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
  3. shikimate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00053; UER00087.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate dehydrogenase (EC:1.1.1.25)
Gene namesi
Name:aroE
Ordered Locus Names:MJ1084
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Shikimate dehydrogenasePRO_0000136060Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi243232.MJ1084.

Structurei

Secondary structure

1
282
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 159Combined sources
Helixi21 – 3111Combined sources
Beta strandi36 – 427Combined sources
Helixi45 – 506Combined sources
Helixi51 – 588Combined sources
Beta strandi62 – 654Combined sources
Helixi72 – 765Combined sources
Beta strandi78 – 803Combined sources
Helixi82 – 876Combined sources
Beta strandi92 – 965Combined sources
Beta strandi99 – 1035Combined sources
Helixi106 – 11813Combined sources
Beta strandi125 – 1295Combined sources
Helixi133 – 14210Combined sources
Beta strandi144 – 1518Combined sources
Helixi155 – 16915Combined sources
Helixi173 – 1764Combined sources
Beta strandi177 – 1804Combined sources
Beta strandi191 – 1944Combined sources
Beta strandi217 – 2237Combined sources
Beta strandi227 – 2304Combined sources
Helixi232 – 2387Combined sources
Turni239 – 2413Combined sources
Beta strandi243 – 2453Combined sources
Helixi248 – 26316Combined sources
Helixi269 – 28012Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NVTX-ray2.35A/B1-282[»]
ProteinModelPortaliQ58484.
SMRiQ58484. Positions 1-282.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58484.

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0169.
InParanoidiQ58484.
KOiK00014.
OMAiDYVYLPF.
PhylomeDBiQ58484.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00222. Shikimate_DH_AroE.
InterProiIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
PfamiPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00507. aroE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58484-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MINAKTKVIG LIGHPVEHSF SPIMHNAAFK DKGLNYVYVA FDVLPENLKY
60 70 80 90 100
VIDGAKALGI VGFNVTIPHK IEIMKYLDEI DKDAQLIGAV NTIKIEDGKA
110 120 130 140 150
IGYNTDGIGA RMALEEEIGR VKDKNIVIYG AGGAARAVAF ELAKDNNIII
160 170 180 190 200
ANRTVEKAEA LAKEIAEKLN KKFGEEVKFS GLDVDLDGVD IIINATPIGM
210 220 230 240 250
YPNIDVEPIV KAEKLREDMV VMDLIYNPLE TVLLKEAKKV NAKTINGLGM
260 270 280
LIYQGAVAFK IWTGVEPNIE VMKNAIIDKI TK
Length:282
Mass (Da):30,877
Last modified:November 1, 1996 - v1
Checksum:iE7398E5D642F7BD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99086.1.
PIRiC64435.
RefSeqiNP_248077.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99086; AAB99086; MJ_1084.
GeneIDi1451980.
KEGGimja:MJ_1084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99086.1 .
PIRi C64435.
RefSeqi NP_248077.1. NC_000909.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NVT X-ray 2.35 A/B 1-282 [» ]
ProteinModelPortali Q58484.
SMRi Q58484. Positions 1-282.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ1084.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB99086 ; AAB99086 ; MJ_1084 .
GeneIDi 1451980.
KEGGi mja:MJ_1084.

Phylogenomic databases

eggNOGi COG0169.
InParanoidi Q58484.
KOi K00014.
OMAi DYVYLPF.
PhylomeDBi Q58484.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00087 .

Miscellaneous databases

EvolutionaryTracei Q58484.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00222. Shikimate_DH_AroE.
InterProi IPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view ]
Pfami PF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00507. aroE. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. "Crystal structure of shikimate 5-dehydrogenase (SDH) bound to NADP: insights into function and evolution."
    Padyana A.K., Burley S.K.
    Structure 11:1005-1013(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) IN COMPLEX WITH NADP, SUBUNIT.

Entry informationi

Entry nameiAROE_METJA
AccessioniPrimary (citable) accession number: Q58484
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3