Q58475 (TRPE_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	MJ1075

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	Anthranilate synthase component 1		PRO_0000154128

Sequences

	Sequence		Length	Mass (Da)
	Q58475 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 7094E20F7C2A5124	FASTA	474	54,300
	10 20 30 40 50 60 MIIKKIKMDV CPLDVYEQIR GENTFLLESA EGVPKVARYS ILGKAEGKVI FKNGKLKVES 70 80 90 100 110 120 FTEFGDKAKD LEGKYECPLD ALREVRNEYL KYIDISNIEP IPRFKGGLVG YLSYDIIRYW 130 140 150 160 170 180 IDLSNINPKP INDLKFPDAE FFIVKDFISF DLKEKVINLI AEDDEGIREL ERIIKNAKIG 190 200 210 220 230 240 NNDNKEEKTT ENKDLKIKSN MSKEEFIEAV KKAKEYIFAG DIFQVVLSRR IEIDLDNLDH 250 260 270 280 290 300 LKIYKKVREI NPSPYMYYLD FGDRKIIGSS PEILVRTDYK DNKRLVITRP IAGTIRRGKT 310 320 330 340 350 360 EEEDKELEKK LLSDEKERAE HVMLVDLARN DIGKISKFGT VEVTDFMIIE KYSHVQHIVS 370 380 390 400 410 420 NVVGELKDNY DSFLAVKATF PAGTLSGAPK VRAMEIIEEL EKTWRGPYGG GVGYFGWDDL 430 440 450 460 470 MDLAITIRTF VISKNKGYIQ VGAGIVADSI PENEWEETER KGMANVKTIE SLLK

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB99074.1.
PIR	B64434.
RefSeq	NP_248068.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q58475.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1451971.
GenomeReviews	Gene locus MJ1075 in contig L77117_GR.
KEGG	mja:MJ_1075.
NMPDR	fig|243232.1.peg.1105.
TIGR	MJ1075.
Phylogenomic databases
HOGENOM	HBG507440.
OMA	IRDYMAR.
ProtClustDB	CLSK2517684.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_1075-MONOMER.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR010116. Anthranilate_synth_I_arc. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
KO	K01657.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR01820. TrpE-arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_METJA

Accession

Primary (citable) accession number: Q58475

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program