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Protein

RIO-type serine/threonine-protein kinase Rio2

Gene

rio2

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi76Magnesium 1By similarity1
Binding sitei93ATPPROSITE-ProRule annotation1
Active sitei202Proton acceptorPROSITE-ProRule annotation1
Metal bindingi207Magnesium 2By similarity1
Metal bindingi220Magnesium 1By similarity1
Metal bindingi220Magnesium 2By similarity1
Binding sitei220ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi72 – 77ATPPROSITE-ProRule annotation6
Nucleotide bindingi158 – 164ATPPROSITE-ProRule annotation7
Nucleotide bindingi206 – 207ATPPROSITE-ProRule annotation2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RIO-type serine/threonine-protein kinase Rio2 (EC:2.7.11.1)
Gene namesi
Name:rio2
Ordered Locus Names:MJ1073
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002135351 – 270RIO-type serine/threonine-protein kinase Rio2Add BLAST270

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi243232.MJ_1073.

Structurei

3D structure databases

ProteinModelPortaliQ58473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 270Protein kinasePROSITE-ProRule annotationAdd BLAST206

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG01181. Archaea.
COG0478. LUCA.
InParanoidiQ58473.
KOiK07179.
OMAiHREGYTN.
PhylomeDBiQ58473.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR030484. Rio2.
IPR015285. RIO2_wHTH_N.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10593:SF36. PTHR10593:SF36. 1 hit.
PfamiPF09202. Rio2_N. 1 hit.
[Graphical view]
SMARTiSM00090. RIO. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS01245. RIO1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHHEWVPLD EIVRKAKMPE KDVLYRLKRL NKFGFVVRST YGYAVSMGGY
60 70 80 90 100
DALAINAFVK KGILKAIGNK LGVGKEGDVY TVLLSDGREA VLKFHKHGRT
110 120 130 140 150
CFTRGKRYRG YLADKHHISW LYVSRLTAER EFEILNELFP IVKVPEPIEW
160 170 180 190 200
NRHAIIMGKV VGEELKRLDL SEFMSKEEIK DLFWKIIEEV KKAYEIGYIH
210 220 230 240 250
GDLSEFNILL DENGDFVIID WPQAVPKYHP DAEFYLKRDI WNVIRYFKKY
260 270
KIDKEDEKID VDKIFEYITK
Length:270
Mass (Da):31,881
Last modified:November 1, 1996 - v1
Checksum:i837BCE317A8A5CDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99073.1.
PIRiH64433.
RefSeqiWP_010870585.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB99073; AAB99073; MJ_1073.
GeneIDi1451969.
KEGGimja:MJ_1073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99073.1.
PIRiH64433.
RefSeqiWP_010870585.1. NC_000909.1.

3D structure databases

ProteinModelPortaliQ58473.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99073; AAB99073; MJ_1073.
GeneIDi1451969.
KEGGimja:MJ_1073.

Phylogenomic databases

eggNOGiarCOG01181. Archaea.
COG0478. LUCA.
InParanoidiQ58473.
KOiK07179.
OMAiHREGYTN.
PhylomeDBiQ58473.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR030484. Rio2.
IPR015285. RIO2_wHTH_N.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10593:SF36. PTHR10593:SF36. 1 hit.
PfamiPF09202. Rio2_N. 1 hit.
[Graphical view]
SMARTiSM00090. RIO. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS01245. RIO1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIO2_METJA
AccessioniPrimary (citable) accession number: Q58473
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.