Uncharacterized protein MJ1054 - Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Uncharacterized protein MJ1054
EC=1.1.1.-

Cleaved into the following chain:

Mja UDPGD intein

Gene names

Ordered Locus Names:

MJ1054

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	895 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Post-translational modification

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation Potential.

Sequence similarities

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Contains 1 DOD-type homing endonuclease domain.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Autocatalytic cleavage Protein splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intein-mediated protein splicing Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro endonuclease activity Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 260

260

Uncharacterized protein MJ1054, 1st part Potential

PRO_0000035997

Chain

261 – 714

454

Mja UDPGD intein Potential

PRO_0000035998

Chain

715 – 895

181

Uncharacterized protein MJ1054, 2nd part Potential

PRO_0000035999

Regions

Domain

468 – 614

147

DOD-type homing endonuclease

Nucleotide binding

2 – 19

18

NAD Potential

Sites

Active site

261

1

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q58454 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: B511AA68CCA41445
Show »

FASTA

895

102,615

        10         20         30         40         50         60 
MNISVIGTGY VGLIQAVGLA EFGFDVVGID IDESKVKALN RGECPLYEEG LEGLLKKHVN 

        70         80         90        100        110        120 
KNLTFTTSYK PIKDSDVIFL CVGTPQDKDG NADLRFLFSA VEKIKETIDK EDYKVIVIKS 

       130        140        150        160        170        180 
TVPVGTNRRV KELLKDYNVD VVSNPEFLRE GIAVYDFFNP ERVILGFENL NNKKPIEIME 

       190        200        210        220        230        240 
EVYKYFKDKN IPFVITNWET AELIKYASNA FLATKISFIN ELAKLSDKVK ADIKTISYAM 

       250        260        270        280        290        300 
GLDPRIGNKF LNAGIGYGGS CFHPDEVLFI DRGRGLECIT FKELFELEDK DNVKILSFDG 

       310        320        330        340        350        360 
EKLSLKKLKL ASKRYYNDDL ITLRFNLGRE IKITKDHPVV ILEDGELKIK LTSDVKEGDK 

       370        380        390        400        410        420 
VILPYGNFGE EREIEIDILE ELSKTDLIEK VWIHNKDLAT NEFNIIKPYL SNKYPHDVKR 

       430        440        450        460        470        480 
NGTIRAKDIL PIKEILDKYG SKNRLFTAKS KSTTIPYKIK IDKDFARLIG YYLSEGWISK 

       490        500        510        520        530        540 
DYGRNGVVRK RIGLCFGIHE EEYINDVKNI LNKLGIKYIE KIKDGSHSIL ISSKILAYVF 

       550        560        570        580        590        600 
ENILNCGINC YNKNIPPQMF NAKEEIKWEF LKGLFRGDGG IVRLNNNKNL NIEFATVSKK 

       610        620        630        640        650        660 
MAHSLLILLQ LLGIVASVKK CYNNKSTTMA YIIRINGLEQ VKKIGELFGK KWENYKDIAE 

       670        680        690        700        710        720 
SYKRNIEPLG YKKSDNFAIL EVKEIIKEHY SGYVYSVETE NSLLITSYGI LIHNCFPKDV 

       730        740        750        760        770        780 
KALIKQFENN NIEPILIKAT DIVNEEQIKW FFEKIKNYYG NLNGKTFAVL GLAFKPNTDD 

       790        800        810        820        830        840 
LRESRAIKLI DMLLESGAIV KGFDYVEKAR ENTINMYKLD KSKGFYGYNL YVLDDLYETV 

       850        860        870        880        890 
KNVDGIIITV EYDFNKEDWE KIGNLVKEKV VFDGRNILDV EKIKKLGFKY YGVGR

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References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii."
Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G.

Venter J.C.
Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB99056.1.
PIR	E64431.
RefSeq	NP_248048.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q58454.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1451951.
GenomeReviews	Gene locus MJ1054 in contig L77117_GR.
KEGG	mja:MJ_1054.
NMPDR	fig\|243232.1.peg.1085.
TIGR	MJ1054.
Phylogenomic databases
HOGENOM	HBG541125.
OMA	HEEEYIN.
ProtClustDB	CLSK796708.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_1054-MONOMER.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR003586. Hedgehog_hint_C. IPR003587. Hedgehog_hint_N. IPR006142. INTEIN. IPR004042. Intein_endonuc. IPR006141. Intein_splice_site. IPR016040. NAD(P)-bd_dom. IPR017476. Nucleotide_sugar_DH. IPR014027. UDP-Glc/GDP-Man_DH_C. IPR014026. UDP-Glc/GDP-Man_DH_dimer. IPR001732. UDP-Glc/GDP-Man_DH_N. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00012.
Pfam	PF00984. UDPG_MGDP_dh. 1 hit. PF03720. UDPG_MGDP_dh_C. 1 hit. PF03721. UDPG_MGDP_dh_N. 1 hit. [Graphical view]
PRINTS	PR00379. INTEIN.
SMART	SM00305. HintC. 1 hit. SM00306. HintN. 1 hit. SM00984. UDPG_MGDP_dh_C. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit. SSF52413. UDP-Glc/GDP-Man_DH_C. 1 hit.
TIGRFAMs	TIGR01443. Intein_Cterm. 1 hit. TIGR01445. Intein_Nterm. 1 hit. TIGR03026. NDP-sugDHase. 1 hit.
PROSITE	PS50818. INTEIN_C_TER. 1 hit. PS50819. INTEIN_ENDONUCLEASE. 1 hit. PS50817. INTEIN_N_TER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y1054_METJA

Accession

Primary (citable) accession number: Q58454

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Intein-containing proteins

List of intein-containing protein entries

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Cleaved into the following chain:

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents