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Protein

Elongation factor 2

Gene

fusA

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 35GTPBy similarity8
Nucleotide bindingi94 – 98GTPBy similarity5
Nucleotide bindingi148 – 151GTPBy similarity4

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMJAN243232:G1GKE-1138-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 2
Short name:
EF-2
Gene namesi
Name:fusA
Synonyms:fus
Ordered Locus Names:MJ1048
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000910321 – 726Elongation factor 2Add BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei602DiphthamideBy similarity1

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_1048

Structurei

3D structure databases

ProteinModelPortaliQ58448
SMRiQ58448
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 260tr-type GAdd BLAST242

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01559 Archaea
COG0480 LUCA
InParanoidiQ58448
KOiK03234
OMAiEHLISGM
OrthoDBiPOG093Z00HF
PhylomeDBiQ58448

Family and domain databases

Gene3Di3.30.230.102 hits
HAMAPiMF_00054_A EF_G_EF_2_A, 1 hit
InterProiView protein in InterPro
IPR035647 EFG_III/V
IPR000640 EFG_V-like
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR004543 Transl_elong_EFG/EF2_arc
IPR005517 Transl_elong_EFG/EF2_IV
PfamiView protein in Pfam
PF00679 EFG_C, 1 hit
PF03764 EFG_IV, 1 hit
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PRINTSiPR00315 ELONGATNFCT
SMARTiView protein in SMART
SM00838 EFG_C, 1 hit
SM00889 EFG_IV, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
SSF52540 SSF52540, 1 hit
SSF54211 SSF54211, 1 hit
SSF54980 SSF54980, 2 hits
TIGRFAMsiTIGR00490 aEF-2, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q58448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKRAKMIAK IKELMEKYDR IRNIGICAHI DHGKTTLSDN LLAGAGMISK
60 70 80 90 100
ELAGEQLALD FDEEEAQRGI TIFAANVSMV HTYEGNEYLI NLIDTPGHVD
110 120 130 140 150
FGGDVTRAMR AIDGAIVVVC AVEGVMPQTE TVLRQALRER VKPVLFINKV
160 170 180 190 200
DRLINELKLT PEELQSRFIK IINDINNLIR KMAPEEFKDK WLVRVEDGSV
210 220 230 240 250
AFGSAYNNWA ISVPFMKKSG ITFKDIIKYC EEDRQDELAE KAPLHEVVLD
260 270 280 290 300
MVIKHLPSPP EAQKYRIPHL WKGDLNSEAG KAMLNCDPNG PLAGVITKII
310 320 330 340 350
VDKHAGAVSV CRLFSGRIKQ GDEVYMVNNQ QKAKIQQVSV FMGPERIPVD
360 370 380 390 400
SISAGNICAL VGLKEASAGE TICSPDKIIE PFEAITHISE PVITVAIEAK
410 420 430 440 450
NTKDLPKLIE VLRQVAREDP TVKVEINEET GEHLLSGMGE LHIEIITKLK
460 470 480 490 500
IERDAGIPVE VGQPIVVYRE TVTGQSPVVE SKSPNKHNKL YFVVEPLEES
510 520 530 540 550
VLQAYKEGRI PDVDTKRKLD DKIVQELIKA GMDPEEAKRV MCIYEGNVLI
560 570 580 590 600
NMTRGIVHLD EVKELIIQGF KEAMRNGPLA AEKCQGVKVK LMDAVLHEDA
610 620 630 640 650
IHRGPAQMIP AARFGIRDAM MQANPVLLEP MQFVYINTPQ DFMGAAMREI
660 670 680 690 700
SNRRGQILDM EQEGDMAIIK AKCPVAEMFG FAGAIRGATQ GRCLWSIEFA
710 720
GYEKVPRDMQ EQLIKQIRER KGLKLE
Length:726
Mass (Da):80,989
Last modified:November 1, 1997 - v1
Checksum:iE5C9D63DB0971D31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB99052.1
PIRiG64430
RefSeqiWP_010870561.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB99052; AAB99052; MJ_1048
GeneIDi1451945
KEGGimja:MJ_1048

Similar proteinsi

Entry informationi

Entry nameiEF2_METJA
AccessioniPrimary (citable) accession number: Q58448
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome