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Protein

Elongation factor 2

Gene

fusA

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi28 – 358GTPBy similarity
Nucleotide bindingi94 – 985GTPBy similarity
Nucleotide bindingi148 – 1514GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 2
Short name:
EF-2
Gene namesi
Name:fusA
Synonyms:fus
Ordered Locus Names:MJ1048
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 726726Elongation factor 2PRO_0000091032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei602 – 6021DiphthamideBy similarity

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_1048.

Structurei

3D structure databases

ProteinModelPortaliQ58448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 260242tr-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01559. Archaea.
COG0480. LUCA.
InParanoidiQ58448.
KOiK03234.
OMAiFTGHVTR.
PhylomeDBiQ58448.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00054_A. EF_G_EF_2_A. 1 hit.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004543. Transl_elong_EFG/EF2_arc.
IPR005517. Transl_elong_EFG/EF2_IV.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00490. aEF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKRAKMIAK IKELMEKYDR IRNIGICAHI DHGKTTLSDN LLAGAGMISK
60 70 80 90 100
ELAGEQLALD FDEEEAQRGI TIFAANVSMV HTYEGNEYLI NLIDTPGHVD
110 120 130 140 150
FGGDVTRAMR AIDGAIVVVC AVEGVMPQTE TVLRQALRER VKPVLFINKV
160 170 180 190 200
DRLINELKLT PEELQSRFIK IINDINNLIR KMAPEEFKDK WLVRVEDGSV
210 220 230 240 250
AFGSAYNNWA ISVPFMKKSG ITFKDIIKYC EEDRQDELAE KAPLHEVVLD
260 270 280 290 300
MVIKHLPSPP EAQKYRIPHL WKGDLNSEAG KAMLNCDPNG PLAGVITKII
310 320 330 340 350
VDKHAGAVSV CRLFSGRIKQ GDEVYMVNNQ QKAKIQQVSV FMGPERIPVD
360 370 380 390 400
SISAGNICAL VGLKEASAGE TICSPDKIIE PFEAITHISE PVITVAIEAK
410 420 430 440 450
NTKDLPKLIE VLRQVAREDP TVKVEINEET GEHLLSGMGE LHIEIITKLK
460 470 480 490 500
IERDAGIPVE VGQPIVVYRE TVTGQSPVVE SKSPNKHNKL YFVVEPLEES
510 520 530 540 550
VLQAYKEGRI PDVDTKRKLD DKIVQELIKA GMDPEEAKRV MCIYEGNVLI
560 570 580 590 600
NMTRGIVHLD EVKELIIQGF KEAMRNGPLA AEKCQGVKVK LMDAVLHEDA
610 620 630 640 650
IHRGPAQMIP AARFGIRDAM MQANPVLLEP MQFVYINTPQ DFMGAAMREI
660 670 680 690 700
SNRRGQILDM EQEGDMAIIK AKCPVAEMFG FAGAIRGATQ GRCLWSIEFA
710 720
GYEKVPRDMQ EQLIKQIRER KGLKLE
Length:726
Mass (Da):80,989
Last modified:November 1, 1997 - v1
Checksum:iE5C9D63DB0971D31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99052.1.
PIRiG64430.

Genome annotation databases

EnsemblBacteriaiAAB99052; AAB99052; MJ_1048.
KEGGimja:MJ_1048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99052.1.
PIRiG64430.

3D structure databases

ProteinModelPortaliQ58448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_1048.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB99052; AAB99052; MJ_1048.
KEGGimja:MJ_1048.

Phylogenomic databases

eggNOGiarCOG01559. Archaea.
COG0480. LUCA.
InParanoidiQ58448.
KOiK03234.
OMAiFTGHVTR.
PhylomeDBiQ58448.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00054_A. EF_G_EF_2_A. 1 hit.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004543. Transl_elong_EFG/EF2_arc.
IPR005517. Transl_elong_EFG/EF2_IV.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00490. aEF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEF2_METJA
AccessioniPrimary (citable) accession number: Q58448
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.