Q58441 (MTD_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
F420-dependent methylenetetrahydromethanopterin dehydrogenase
Short name=MTD
EC=1.5.99.9

Alternative name(s):
Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase

Gene names

Name:	mtd
Ordered Locus Names:	MJ1035

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible reduction of methenyl-H4MPT+ to methylene-H4MPT By similarity. HAMAP MF_00058
Catalytic activity	5,10-methylenetetrahydromethanopterin + coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420. HAMAP MF_00058
Pathway	One-carbon metabolism; methanogenesis from CO(2); 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (coenzyme F420 route): step 1/1. HAMAP MF_00058
Sequence similarities	Belongs to the MTD family.

Ontologies

Keywords
Biological process	Methanogenesis One-carbon metabolism
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ferredoxin hydrogenase activity Inferred from electronic annotation. Source: InterPro methylenetetrahydromethanopterin dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	F420-dependent methylenetetrahydromethanopterin dehydrogenase HAMAP MF_00058		PRO_0000075038

Sequences

	Sequence		Length	Mass (Da)
	Q58441 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 93A1D2357CC85DDF	FASTA	277	30,306
	10 20 30 40 50 60 MVVKIGIIKC GNIGMSPVVD LALDERADRK DIAVRVLGSG AKMDPESVEE VTKKMVEEVK 70 80 90 100 110 120 PDFIIYIGPN PAAPGPKKAR EILSQSGIPA VIIGDAPGLR VKDEMEQQGL GYIIIKCDPM 130 140 150 160 170 180 IGARREFLDP VEMALFNADV IRVLAGTGAL RIVQEAIDKM IDAVKEGKEI ELPKIVITEQ 190 200 210 220 230 240 KAVEAMEFTN PYAKAKAMAA FTIAEKVGDV DVKGCFMTKE AEKYIPIVAS AHEMIRYAAK 250 260 270 LVDEARELEK AMDAVSRKPH HPEGKRLSKK ALMEKPE

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB99039.1.
PIR	B64429.
RefSeq	NP_248029.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q58441.
SMR	Q58441. Positions 2-277.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1451932.
GenomeReviews	Gene locus MJ1035 in contig L77117_GR.
KEGG	mja:MJ_1035.
NMPDR	fig|243232.1.peg.1066.
TIGR	MJ1035.
Phylogenomic databases
HOGENOM	HBG538567.
OMA	NPYAKAK.
ProtClustDB	PRK00994.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_1035-MONOMER.
Family and domain databases
HAMAP	MF_00058. MTD. [Tree]
InterPro	IPR002844. Methylene_DH. [Graphical view]
KO	K00319.
Pfam	PF01993. MTD. 1 hit. [Graphical view]
PIRSF	PIRSF005627. MTD. 1 hit.
ProDom	PD017604. Methylene_DH. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF102324. MeTD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MTD_METJA

Accession

Primary (citable) accession number: Q58441

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program