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Protein

Archaeosine synthase

Gene

arcS

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of 7-cyano-7-deazaguanine (preQ0) to archaeosine. It can also use asparagine in place of glutamine.2 Publications

Catalytic activityi

L-glutamine + 7-cyano-7-carbaguanine(15) in tRNA + H2O = L-glutamate + archaeine(15) in tRNA.1 Publication

Temperature dependencei

Optimum temperature is 40 degrees Celsius. It decreases significantly at temperatures above 45 degrees Celsius.1 Publication

Pathwayi: archaeosine-tRNA biosynthesis

This protein is involved in the pathway archaeosine-tRNA biosynthesis, which is part of tRNA modification.
View all proteins of this organism that are known to be involved in the pathway archaeosine-tRNA biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

  • archaeosine-tRNA biosynthetic process Source: UniProtKB
  • tRNA modification Source: UniProtKB

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16209.
UniPathwayiUPA00393.

Names & Taxonomyi

Protein namesi
Recommended name:
Archaeosine synthase (EC:2.6.1.97)
Alternative name(s):
Glutamine:preQ0-tRNA amidinotransferase
Gene namesi
Name:arcS
Ordered Locus Names:MJ1022
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001071461 – 569Archaeosine synthaseAdd BLAST569

Proteomic databases

PRIDEiQ58428.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi243232.MJ_1022.

Structurei

3D structure databases

ProteinModelPortaliQ58428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini495 – 569PUAPROSITE-ProRule annotationAdd BLAST75

Phylogenomic databases

eggNOGiarCOG00990. Archaea.
COG1549. LUCA.
InParanoidiQ58428.
KOiK07557.
OMAiYPAAHYD.
OrthoDBiPOG093Z0DR7.
PhylomeDBiQ58428.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiView protein in InterPro
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR002616. tRNA_ribo_trans-like.
IPR004521. Uncharacterised_CHP00451.
IPR005122. Uracil-DNA_glycosylase-like.
PfamiView protein in Pfam
PF01472. PUA. 1 hit.
SMARTiView protein in SMART
SM00359. PUA. 1 hit.
SUPFAMiSSF51713. SSF51713. 1 hit.
SSF52141. SSF52141. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00451. unchar_dom_2. 1 hit.
PROSITEiView protein in PROSITE
PS50890. PUA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEPIAYDIG RLCKEEDKEL TPKLIDIDVI GLSQEKIFYG IMTPFRCPNS
60 70 80 90 100
KSIYELRKSY VKADGIKMPF DTFRELTSIF KKSFIGTVKY KGNVFKYQIL
110 120 130 140 150
NFGKHVDLIE LEDADLYIIA DGRRLIERKE LQIIPKIREK ISPNSAIYSP
160 170 180 190 200
AVFPWEIPLL AYIGVDYFDD SLAKLYASMG YKFTKNRAVK VDSFSFEELY
210 220 230 240 250
NNNKKVYEEI LEEVRIAIKN GFLRNVVEET AVSHPYLWAN YRRYEPDLRN
260 270 280 290 300
IPLSKENKII VTTNINIPEV KKYLERLDNY EPYSNIIVLL PCSSKKPYSI
310 320 330 340 350
SQSHQKFIKA IKSAKVVVEE VILTSPYGLV PRALERLVNY DIPVTGEWSF
360 370 380 390 400
EEIELINNCL KNFLKKVKEK FDDYIVIAHL PEHYLEILEL DDIVITSKGN
410 420 430 440 450
PTSEEALKNL TDTLKKYKEL TKSKDINKKG QRIHNIQQLA EFQFGINFIP
460 470 480 490 500
NEIFINHKGQ IFTKINNKNQ QIASINPKNG LLILTLSGGE LLWNSGGKDI
510 520 530 540 550
NYIEVNYEIK KGSLFPPGFV DCNENISYND EVVLIKDDTF LGIGRALMSG
560
FEMKKAKHGA LVNIRNVKS
Length:569
Mass (Da):65,582
Last modified:November 1, 1996 - v1
Checksum:iE29EC27908E366ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB99026.1.
PIRiE64427.

Genome annotation databases

EnsemblBacteriaiAAB99026; AAB99026; MJ_1022.
KEGGimja:MJ_1022.

Entry informationi

Entry nameiARCS_METJA
AccessioniPrimary (citable) accession number: Q58428
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways