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Q58401

- HEM4_METJA

UniProt

Q58401 - HEM4_METJA

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Protein
Putative uroporphyrinogen-III synthase
Gene
hemD, MJ0994
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi

GO - Molecular functioni

  1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:hemD
Ordered Locus Names:MJ0994
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Putative uroporphyrinogen-III synthase
PRO_0000135249Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ0994.

Structurei

3D structure databases

ProteinModelPortaliQ58401.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1587.
KOiK01719.
OMAiELYETIF.
PhylomeDBiQ58401.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58401-1 [UniParc]FASTAAdd to Basket

« Hide

MKVVITRPKE RADVFASLLK KEGFEPIIFP TLEIVYNKDL DVNLDSYDWI    50
AFTSPSGVIG LYNILTENER ENVKNKKIAV IGEKTAKTFK KYFGRDPDIM 100
PNEYTAESLL REIKKVSKEE EKFLIPTTPS TRDVLKNNLN ADLLFVYKSA 150
EPENLKEDIK KLKELIAKDK FILTFTSGLT AKNFFKYVDD EFAEIIKDNY 200
IVAIGPITAK VIEKFGFKPL IPKVYTIEGM LEVIRTLKER 240
Length:240
Mass (Da):27,614
Last modified:November 1, 1996 - v1
Checksum:iF0AA2E8CCEF9BAE8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98999.1.
PIRiB64424.
RefSeqiNP_247989.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98999; AAB98999; MJ_0994.
GeneIDi1451892.
KEGGimja:MJ_0994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98999.1 .
PIRi B64424.
RefSeqi NP_247989.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58401.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0994.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98999 ; AAB98999 ; MJ_0994 .
GeneIDi 1451892.
KEGGi mja:MJ_0994.

Phylogenomic databases

eggNOGi COG1587.
KOi K01719.
OMAi ELYETIF.
PhylomeDBi Q58401.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00320 .

Family and domain databases

InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view ]
Pfami PF02602. HEM4. 1 hit.
[Graphical view ]
SUPFAMi SSF69618. SSF69618. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiHEM4_METJA
AccessioniPrimary (citable) accession number: Q58401
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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