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Q58401 (HEM4_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative uroporphyrinogen-III synthase

Short name=UROS
EC=4.2.1.75
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene names
Name:hemD
Ordered Locus Names:MJ0994
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.

Catalytic activity

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.

Sequence similarities

Belongs to the uroporphyrinogen-III synthase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionuroporphyrinogen-III synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240Putative uroporphyrinogen-III synthase
PRO_0000135249

Sequences

Sequence LengthMass (Da)Tools
Q58401 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F0AA2E8CCEF9BAE8

FASTA24027,614
        10         20         30         40         50         60 
MKVVITRPKE RADVFASLLK KEGFEPIIFP TLEIVYNKDL DVNLDSYDWI AFTSPSGVIG 

        70         80         90        100        110        120 
LYNILTENER ENVKNKKIAV IGEKTAKTFK KYFGRDPDIM PNEYTAESLL REIKKVSKEE 

       130        140        150        160        170        180 
EKFLIPTTPS TRDVLKNNLN ADLLFVYKSA EPENLKEDIK KLKELIAKDK FILTFTSGLT 

       190        200        210        220        230        240 
AKNFFKYVDD EFAEIIKDNY IVAIGPITAK VIEKFGFKPL IPKVYTIEGM LEVIRTLKER 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB98999.1.
PIRB64424.
RefSeqNP_247989.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ58401.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ0994.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB98999; AAB98999; MJ_0994.
GeneID1451892.
KEGGmja:MJ_0994.

Phylogenomic databases

eggNOGCOG1587.
KOK01719.
OMAELYETIF.
PhylomeDBQ58401.

Enzyme and pathway databases

UniPathwayUPA00251; UER00320.

Family and domain databases

InterProIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMSSF69618. SSF69618. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEM4_METJA
AccessionPrimary (citable) accession number: Q58401
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names