Reviewed,
UniProtKB/Swiss-Prot Q58392 (MTM1_METJA)
Last modified
January 19, 2010.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Modification methylase MjaI Short name=M.MjaI EC=2.1.1.113 Alternative name(s): N-4 cytosine-specific methyltransferase MjaI | ||||
| Gene names |
| ||||
| Organism | Methanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 2190 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus |
Protein attributes
| Sequence length | 303 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | This methylase recognizes the double-stranded sequence CTAG, causes specific methylation on C-1 on both strands, and protects the DNA from cleavage by the MjaI endonuclease Potential. |
| Catalytic activity | S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N(4)-methylcytosine. |
| Sequence similarities | Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Restriction system |
| Ligand | S-adenosyl-L-methionine |
| Molecular function | Methyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA methylation on cytosine Inferred from electronic annotation. Source: InterPro DNA restriction-modification systemInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | DNA binding Inferred from electronic annotation. Source: InterPro N-methyltransferase activityInferred from electronic annotation. Source: InterPro site-specific DNA-methyltransferase (cytosine-N4-specific) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 303 | 303 | Modification methylase MjaI | PRO_0000087936 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. Venter J.C.Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440. |
| [2] | "Method for screening restriction endonucleases." Noren C.J., Roberts R.J., Patti J., Byrd D.R., Morgan R.D. Patent number WO9911821, 11-MAR-1999 Cited for: CHARACTERIZATION. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L77117 Genomic DNA. Translation: AAB98988.1. |
| PIR | A64423. |
| RefSeq | NP_247980.1. |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| REBASE | 3889. M.MjaI. |
Genome annotation databases | |
| GeneID | 1451883. |
| GenomeReviews | Gene locus MJ0985 in contig L77117_GR. |
| KEGG | mja:MJ0985. |
| NMPDR | fig|243232.1.peg.1017. |
| TIGR | MJ0985. |
Phylogenomic databases | |
| HOGENOM | HBG405684. |
| OMA | MIEMWDE. |
Enzyme and pathway databases | |
| BRENDA | 2.1.1.113. 256362. |
Family and domain databases | |
| InterPro | IPR002941. DNA_methylase_N4/N6. IPR001091. MeTrfase_CN4. IPR017985. MeTrfase_CN4_CS. [Graphical view] |
| Pfam | PF01555. N6_N4_Mtase. 1 hit. [Graphical view] |
| PRINTS | PR00508. S21N4MTFRASE. |
| PROSITE | PS00093. N4_MTASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MTM1_METJA | ||||||||
| Accession | Primary (citable) accession number: Q58392 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Methanococcus jannaschii Methanococcus jannaschii: entries and gene names |
| Restriction enzymes and methylases Classification of restriction enzymes and methylases and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


