Q58378 (PATS_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Soluble P-type ATPase-like phosphatase
EC=3.6.3.-

Gene names

Name:	patS
Ordered Locus Names:	MJ0968

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Most probably acts as a phosphatase in the cytosol.
Cofactor	Magnesium.
Enzyme regulation	Inhibited by orthovanadate.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]
Biophysicochemical properties	Temperature dependence: Optimum temperature is 50 degrees Celsius.

Ontologies

Keywords
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cation transport Inferred from electronic annotation. Source: InterPro
Cellular component	membrane Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Soluble P-type ATPase-like phosphatase		PRO_0000046397
Sites
	Active site	8	1	4-aspartylphosphate intermediate Probable

Sequences

	Sequence		Length	Mass (Da)
	Q58378 [UniParc]. Last modified November 1, 1998. Version 3. Checksum: FC6D56FD985E4381	FASTA	273	30,739
	10 20 30 40 50 60 MKVAIVFDSA GTLVKIMRVI KDLKKNKFIC NSQTVDIVDK KKGRALVIIK EDPLKVVDKE 70 80 90 100 110 120 NPEKLISDLL KEVEIGISYC NPPINREGIF KDRKTKVKEL QEPLNILKRY EVETGYGSAL 130 140 150 160 170 180 IIDTYAGEVE YTIATAGCLF KEVKETIKQL KDLGVKVFIA SGDRKGFIKR LAEITGVDER 190 200 210 220 230 240 YIMAEAHQEL KRDLIRNLKK EGYFTIMVGD GANDVPAMIE SDLAVVTLQN GNVSRRALET 250 260 270 ADIKIYNIKE IVDICKKVIN GEIKGRMQIK ECS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
[2]	"Soluble P-type ATPase from an archaeon, Methanococcus jannaschii." Ogawa H., Haga T., Toyoshima C. FEBS Lett. 471:99-102(2000) [PubMed: 10760521] [Abstract] Cited for: CHARACTERIZATION.
[3]	"The Methanocaldococcus jannaschii protein Mj0968 is not a P-type ATPase." Bramkamp M., Gassel M., Herkenhoff-Hesselmann B., Bertrand J., Altendorf K. FEBS Lett. 543:31-36(2003) [PubMed: 12753900] [Abstract] Cited for: CHARACTERIZATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98973.1.
PIR	H64420.
RefSeq	NP_247963.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q58378.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1451866.
GenomeReviews	Gene locus MJ0968 in contig L77117_GR.
KEGG	mja:MJ_0968.
NMPDR	fig|243232.1.peg.1000.
TIGR	MJ0968.
Phylogenomic databases
HOGENOM	HBG545847.
OMA	FDSAGTL.
ProtClustDB	CLSK876407.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_0968-MONOMER.
Family and domain databases
InterPro	IPR001757. ATPase_P-typ_ion-transptr. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.1000. HAD-like_dom. 1 hit.
KO	K01533.
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
PROSITE	PS00154. ATPASE_E1_E2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PATS_METJA

Accession

Primary (citable) accession number: Q58378

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1998
Last modified:	December 14, 2011
This is version 78 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program