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Q58375 (SUMT_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen-III C-methyltransferase

Short name=Urogen III methylase
EC=2.1.1.107
Alternative name(s):
SUMT
Uroporphyrinogen III methylase
Short name=UROM
Gene names
Name:cobA
Synonyms:corA
Ordered Locus Names:MJ0965
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin By similarity.

Catalytic activity

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.

S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.

Sequence similarities

Belongs to the precorrin methyltransferase family.

Sequence caution

The sequence AAB98967.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242Uroporphyrinogen-III C-methyltransferase
PRO_0000150371

Regions

Region88 – 903S-adenosyl-L-methionine binding By similarity

Sites

Binding site121S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site1181S-adenosyl-L-methionine By similarity
Binding site1701S-adenosyl-L-methionine; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q58375 [UniParc].

Last modified January 16, 2004. Version 2.
Checksum: BBE8388F036B6851

FASTA24226,340
        10         20         30         40         50         60 
MTGKVILVGA GPGDPELITI KGLKAIKEAD VVVYDDLISK ELLNYAKKDA ELIYVGKRKG 

        70         80         90        100        110        120 
KHSFKQEEIN KILVEKAKEG KLVVRLKGGD PFVFGRGGEE ILELKKHNIP YEVIPGITSA 

       130        140        150        160        170        180 
IAVPEVAGIP VTHRKVATSF TVVTGHEAED KKEKQVDLSK LNADTIVILM GITNLENLVK 

       190        200        210        220        230        240 
ELLQNPKRSK ETPVAIIMEG TTKNQRVIKG TLGDIVEKAK KENARPPGVI VVGEVVNVLD 


SQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB98967.1. Different initiation.
PIRE64420.
RefSeqNP_247960.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ58375.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ0965.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB98967; AAB98967; MJ_0965.
GeneID1451863.
KEGGmja:MJ_0965.

Phylogenomic databases

eggNOGCOG0007.
KOK02303.
OMAPAAFIHW.
PhylomeDBQ58375.

Enzyme and pathway databases

UniPathwayUPA00148; UER00211.

Family and domain databases

Gene3D3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamPF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMSSF53790. SSF53790. 1 hit.
TIGRFAMsTIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEPS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUMT_METJA
AccessionPrimary (citable) accession number: Q58375
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: July 9, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names