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Q58347 (PUR2_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase

EC=6.3.4.13
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene names
Name:purD
Ordered Locus Names:MJ0937
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
PRO_0000151510

Regions

Domain109 – 324216ATP-grasp
Nucleotide binding140 – 20263ATP By similarity

Sites

Metal binding2821Magnesium or manganese 1 By similarity
Metal binding2941Magnesium or manganese 1 By similarity
Metal binding2941Magnesium or manganese 2 By similarity
Metal binding2961Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q58347 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 9AD115FBC8AB8BD1

FASTA44449,098
        10         20         30         40         50         60 
MKILLIGGGA RESAIAHALK KNEEVKLYTL MKNKNPGIAR LSEEIKLAKE TDLDAVKEFA 

        70         80         90        100        110        120 
EKVKPDLAVI GPEAPLGEGV VDLLEEMGIS AVGPKKLAAQ IETNKEFMRN LFKKYNIKGS 

       130        140        150        160        170        180 
LMYKAFEEYG EELESFIDEL TEKGIKAVVK PVGLTGGKGV KVVGEQLKDN EEAKKYAKEI 

       190        200        210        220        230        240 
FETGLGGGKV LIEEKLEGVE FTLHGFVDGD TIKFTPFVQD HPHALEGDEG SITGGMGSYS 

       250        260        270        280        290        300 
CPDHKLPFMT EEDVKLAKEI MEETVKALKE EVGGYKGILY GQFMLTKEGP KIIEYNARFG 

       310        320        330        340        350        360 
DPEAMNLLAI LKNDFLEVCE AIVNKKLKDI DVEFENKATV CKYVVPKGYP DNPVRGEPIT 

       370        380        390        400        410        420 
VDEEAIKKTG AILHYASVNE DNGSLYMTGS RAVAVVGVAD TIEEAERIAE EATKYIKGEV 

       430        440 
YHRSDIGKKE LIKKRIEKMN ELRR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB98942.1.
PIRA64417.
RefSeqNP_247932.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ58347.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ0937.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB98942; AAB98942; MJ_0937.
GeneID1451833.
KEGGmja:MJ_0937.

Phylogenomic databases

eggNOGCOG0151.
KOK01945.
OMAYKGFLYA.
PhylomeDBQ58347.

Enzyme and pathway databases

UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR2_METJA
AccessionPrimary (citable) accession number: Q58347
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names