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Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable L-aspartate dehydrogenase (nadX)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124NAD; via amide nitrogenUniRule annotation1
Binding sitei190NADUniRule annotation1
Active sitei218UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandNAD, NADP

Enzyme and pathway databases

BioCyciMJAN243232:G1GKE-994-MONOMER
UniPathwayiUPA00253; UER00456

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
Gene namesi
Name:nadXUniRule annotation
Ordered Locus Names:MJ0915
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448961 – 267Probable L-aspartate dehydrogenaseAdd BLAST267

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0915

Structurei

3D structure databases

ProteinModelPortaliQ58325
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00254 Archaea
COG1712 LUCA
InParanoidiQ58325
KOiK06989
OMAiMIMSVGA
OrthoDBiPOG093Z0FE7
PhylomeDBiQ58325

Family and domain databases

HAMAPiMF_01265 NadX, 1 hit
InterProiView protein in InterPro
IPR005106 Asp/hSer_DH_NAD-bd
IPR002811 Asp_DH
IPR022487 Asp_DH_arc
IPR020626 Asp_DH_prok
IPR011182 L-Asp_DH
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01958 DUF108, 1 hit
PF03447 NAD_binding_3, 1 hit
PIRSFiPIRSF005227 Asp_dh_NAD_syn, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03855 NAD_NadX, 1 hit

Sequencei

Sequence statusi: Complete.

Q58325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIGIVGCG AIGNFITKKV LDGTIKNAKI SAVYDRNFDK AKTLSERTGA
60 70 80 90 100
KICSSIDDLV KEDLDLVVEA ASIKAVEEIA EKSLINNKDV LIMSVGALAD
110 120 130 140 150
KKLFLKLRDL AKTVGRKIYL PSGAIGGLDA IKALRLGEIE EVVLKTTKPV
160 170 180 190 200
AALEDALKNL GYKPEDIKNP VIVFEGDVFK AIKEFPANIN VSVTLSIAAE
210 220 230 240 250
FPAKVVIVAD PNAKLNKHEL FVKSSIGTLR VCIENVPFEE NPRTSALAAY
260
SAVRLIRDLA EPVKVGT
Length:267
Mass (Da):28,755
Last modified:November 1, 1996 - v1
Checksum:iB2C427DFD3AE1A4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB98920.1
PIRiC64414
RefSeqiWP_010870429.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB98920; AAB98920; MJ_0915
GeneIDi1451804
KEGGimja:MJ_0915

Similar proteinsi

Entry informationi

Entry nameiASPD_METJA
AccessioniPrimary (citable) accession number: Q58325
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health