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Q58295

- DPOL_METJA

UniProt

Q58295 - DPOL_METJA

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Protein

DNA polymerase

Gene

pol

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
  3. endonuclease activity Source: InterPro
  4. nucleotide binding Source: InterPro

GO - Biological processi

  1. intein-mediated protein splicing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase (EC:2.7.7.7)
Cleaved into the following 2 chains:
Gene namesi
Name:pol
Ordered Locus Names:MJ0885
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425DNA polymerase, 1st partSequence AnalysisPRO_0000007317Add
BLAST
Chaini426 – 794369Mja pol-1 inteinSequence AnalysisPRO_0000007318Add
BLAST
Chaini795 – 88288DNA polymerase, 2nd partSequence AnalysisPRO_0000007319Add
BLAST
Chaini883 – 1358476Mja pol-2 inteinSequence AnalysisPRO_0000007320Add
BLAST
Chaini1359 – 1634276DNA polymerase, 3rd partSequence AnalysisPRO_0000007321Add
BLAST

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.Curated

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ0885.

Structurei

3D structure databases

ProteinModelPortaliQ58295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini552 – 693142DOD-type homing endonuclease 1PROSITE-ProRule annotationAdd
BLAST
Domaini1163 – 1295133DOD-type homing endonuclease 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated
Contains 2 DOD-type homing endonuclease domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0417.
InParanoidiQ58295.
KOiK02319.
OMAiERRINIK.

Family and domain databases

Gene3Di2.170.16.10. 4 hits.
3.10.28.10. 2 hits.
3.30.420.10. 1 hit.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR027434. Homing_endonucl.
IPR006142. INTEIN.
IPR004042. Intein_endonuc.
IPR006141. Intein_splice_site.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 3 hits.
PF03104. DNA_pol_B_exo1. 1 hit.
PF14528. LAGLIDADG_3. 1 hit.
[Graphical view]
PRINTSiPR00379. INTEIN.
SMARTiSM00305. HintC. 2 hits.
SM00306. HintN. 2 hits.
SM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF51294. SSF51294. 4 hits.
SSF53098. SSF53098. 1 hit.
SSF55608. SSF55608. 2 hits.
TIGRFAMsiTIGR01443. intein_Cterm. 2 hits.
TIGR01445. intein_Nterm. 1 hit.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
PS50818. INTEIN_C_TER. 2 hits.
PS50819. INTEIN_ENDONUCLEASE. 2 hits.
PS50817. INTEIN_N_TER. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58295-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGMSMGKIKI DALIDNTYKT IEDKAVIYLY LINSILKDRD FKPYFYVELH
60 70 80 90 100
KEKVENEDIE KIKEFLLKND LLKFVENIEV VKKIILRKEK EVIKIIATHP
110 120 130 140 150
QKVPKLRKIK ECEIVKEIYE HDIPFAKRYL IDNEIIPMTY WDFENKKPVS
160 170 180 190 200
IEIPKLKSVA FDMEVYNRDT EPNPERDPIL MASFWDENGG KVITYKEFNH
210 220 230 240 250
PNIEVVKNEK ELIKKIIETL KEYDVIYTYN GDNFDFPYLK ARAKIYGIDI
260 270 280 290 300
NLGKDGEELK IKRGGMEYRS YIPGRVHIDL YPISRRLLKL TKYTLEDVVY
310 320 330 340 350
NLFGIEKLKI PHTKIVDYWA NNDKTLIEYS LQDAKYTYKI GKYFFPLEVM
360 370 380 390 400
FSRIVNQTPF EITRMSSGQM VEYLLMKRAF KENMIVPNKP DEEEYRRRVL
410 420 430 440 450
TTYEGGYVKE PEKGMFEDII SMDFRCHPKG TKVVVKGKGI VNIEDVKEGN
460 470 480 490 500
YVLGIDGWQK VKKVWKYEYE GELINVNGLK CTPNHKIPLR YKIKHKKINK
510 520 530 540 550
NDYLVRDIYA KSLLTKFKGE GKLILCKDFE TIGNYEKYIN DMDEDFILKS
560 570 580 590 600
ELIGILLAEG HLLRRDIEYF DSSRGKKRIS HQYRVEITVN EDEKDFIEKI
610 620 630 640 650
KYIFKKLFNY ELYVRRKKGT KAITLGCAKK DIYLKIEEIL KNKEKYLPNA
660 670 680 690 700
ILRGFFEGDG YVNTVRRAVV VNQGTNNYDK IKFIASLLDR LGIKYSFYTY
710 720 730 740 750
SYEERGKKLK RYVIEIFSKG DLIKFSILIS FISRRKNNLL NEIIRQKTLY
760 770 780 790 800
KIGDYGFYDL DDVCVSLESY KGEVYDLTLE GRPYYFANGI LTHNSLYPSI
810 820 830 840 850
IISYNISPDT LDCECCKDVS EKILGHWFCK KKEGLIPKTL RNLIERRINI
860 870 880 890 900
KRRMKKMAEI GEINEEYNLL DYEQKSLKIL ANSILPDEYL TIIEEDGIKV
910 920 930 940 950
VKIGEYIDDL MRKHKDKIKF SGISEILETK NLKTFSFDKI TKKCEIKKVK
960 970 980 990 1000
ALIRHPYFGK AYKIKLRSGR TIKVTRGHSL FKYENGKIVE VKGDDVRFGD
1010 1020 1030 1040 1050
LIVVPKKLTC VDKEVVINIP KRLINADEEE IKDLVITKHK DKAFFVKLKK
1060 1070 1080 1090 1100
TLEDIENNKL KVIFDDCILY LKELGLIDYN IIKKINKVDI KILDEEKFKA
1110 1120 1130 1140 1150
YKKYFDTVIE HGNFKKGRCN IQYIKIKDYI ANIPDKEFED CEIGAYSGKI
1160 1170 1180 1190 1200
NALLKLDEKL AKFLGFFVTR GRLKKQKLKG ETVYEISVYK SLPEYQKEIA
1210 1220 1230 1240 1250
ETFKEVFGAG SMVKDKVTMD NKIVYLVLKY IFKCGDKDKK HIPEELFLAS
1260 1270 1280 1290 1300
ESVIKSFLDG FLKAKKNSHK GTSTFMAKDE KYLNQLMILF NLVGIPTRFT
1310 1320 1330 1340 1350
PVKNKGYKLT LNPKYGTVKD LMLDEVKEIE AFEYSGYVYD LSVEDNENFL
1360 1370 1380 1390 1400
VNNIYAHNSV YGYLAFPRAR FYSRECAEIV TYLGRKYILE TVKEAEKFGF
1410 1420 1430 1440 1450
KVLYIDTDGF YAIWKEKISK EELIKKAMEF VEYINSKLPG TMELEFEGYF
1460 1470 1480 1490 1500
KRGIFVTKKR YALIDENGRV TVKGLEFVRR DWSNIAKITQ RRVLEALLVE
1510 1520 1530 1540 1550
GSIEKAKKII QDVIKDLREK KIKKEDLIIY TQLTKDPKEY KTTAPHVEIA
1560 1570 1580 1590 1600
KKLMREGKRI KVGDIIGYII VKGTKSISER AKLPEEVDID DIDVNYYIDN
1610 1620 1630
QILPPVLRIM EAVGVSKNEL KKEGAQLTLD KFFK
Length:1,634
Mass (Da):191,710
Last modified:December 15, 1998 - v2
Checksum:i84A1FAFAB1F97DDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98889.1.
PIRiE64410.
RefSeqiNP_247880.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98889; AAB98889; MJ_0885.
GeneIDi1451774.
KEGGimja:MJ_0885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98889.1 .
PIRi E64410.
RefSeqi NP_247880.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58295.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0885.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98889 ; AAB98889 ; MJ_0885 .
GeneIDi 1451774.
KEGGi mja:MJ_0885.

Phylogenomic databases

eggNOGi COG0417.
InParanoidi Q58295.
KOi K02319.
OMAi ERRINIK.

Family and domain databases

Gene3Di 2.170.16.10. 4 hits.
3.10.28.10. 2 hits.
3.30.420.10. 1 hit.
InterProi IPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR027434. Homing_endonucl.
IPR006142. INTEIN.
IPR004042. Intein_endonuc.
IPR006141. Intein_splice_site.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF00136. DNA_pol_B. 3 hits.
PF03104. DNA_pol_B_exo1. 1 hit.
PF14528. LAGLIDADG_3. 1 hit.
[Graphical view ]
PRINTSi PR00379. INTEIN.
SMARTi SM00305. HintC. 2 hits.
SM00306. HintN. 2 hits.
SM00486. POLBc. 1 hit.
[Graphical view ]
SUPFAMi SSF51294. SSF51294. 4 hits.
SSF53098. SSF53098. 1 hit.
SSF55608. SSF55608. 2 hits.
TIGRFAMsi TIGR01443. intein_Cterm. 2 hits.
TIGR01445. intein_Nterm. 1 hit.
PROSITEi PS00116. DNA_POLYMERASE_B. 1 hit.
PS50818. INTEIN_C_TER. 2 hits.
PS50819. INTEIN_ENDONUCLEASE. 2 hits.
PS50817. INTEIN_N_TER. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiDPOL_METJA
AccessioniPrimary (citable) accession number: Q58295
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: October 29, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Intein-containing proteins
    List of intein-containing protein entries
  2. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3