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Q58295

- DPOL_METJA

UniProt

Q58295 - DPOL_METJA

Protein

DNA polymerase

Gene

pol

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (15 Dec 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
    3. endonuclease activity Source: InterPro
    4. nucleotide binding Source: InterPro

    GO - Biological processi

    1. intein-mediated protein splicing Source: InterPro

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    DNA-binding

    Protein family/group databases

    MEROPSiN10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase (EC:2.7.7.7)
    Cleaved into the following 2 chains:
    Gene namesi
    Name:pol
    Ordered Locus Names:MJ0885
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425DNA polymerase, 1st partSequence AnalysisPRO_0000007317Add
    BLAST
    Chaini426 – 794369Mja pol-1 inteinSequence AnalysisPRO_0000007318Add
    BLAST
    Chaini795 – 88288DNA polymerase, 2nd partSequence AnalysisPRO_0000007319Add
    BLAST
    Chaini883 – 1358476Mja pol-2 inteinSequence AnalysisPRO_0000007320Add
    BLAST
    Chaini1359 – 1634276DNA polymerase, 3rd partSequence AnalysisPRO_0000007321Add
    BLAST

    Post-translational modificationi

    This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.Curated

    Keywords - PTMi

    Autocatalytic cleavage, Protein splicing

    Interactioni

    Protein-protein interaction databases

    STRINGi243232.MJ0885.

    Structurei

    3D structure databases

    ProteinModelPortaliQ58295.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini552 – 693142DOD-type homing endonuclease 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1163 – 1295133DOD-type homing endonuclease 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DNA polymerase type-B family.Curated
    Contains 2 DOD-type homing endonuclease domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0417.
    KOiK02319.
    OMAiERRINIK.

    Family and domain databases

    Gene3Di2.170.16.10. 4 hits.
    3.10.28.10. 2 hits.
    3.30.420.10. 1 hit.
    InterProiIPR006172. DNA-dir_DNA_pol_B.
    IPR017964. DNA-dir_DNA_pol_B_CS.
    IPR006133. DNA-dir_DNA_pol_B_exonuc.
    IPR006134. DNA-dir_DNA_pol_B_multi_dom.
    IPR028992. Hedgehog/Intein_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR027434. Homing_endonucl.
    IPR006142. INTEIN.
    IPR004042. Intein_endonuc.
    IPR006141. Intein_splice_site.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PfamiPF00136. DNA_pol_B. 3 hits.
    PF03104. DNA_pol_B_exo1. 1 hit.
    PF14528. LAGLIDADG_3. 1 hit.
    [Graphical view]
    PRINTSiPR00379. INTEIN.
    SMARTiSM00305. HintC. 2 hits.
    SM00306. HintN. 2 hits.
    SM00486. POLBc. 1 hit.
    [Graphical view]
    SUPFAMiSSF51294. SSF51294. 4 hits.
    SSF53098. SSF53098. 1 hit.
    SSF55608. SSF55608. 2 hits.
    TIGRFAMsiTIGR01443. intein_Cterm. 2 hits.
    TIGR01445. intein_Nterm. 1 hit.
    PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
    PS50818. INTEIN_C_TER. 2 hits.
    PS50819. INTEIN_ENDONUCLEASE. 2 hits.
    PS50817. INTEIN_N_TER. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q58295-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGMSMGKIKI DALIDNTYKT IEDKAVIYLY LINSILKDRD FKPYFYVELH     50
    KEKVENEDIE KIKEFLLKND LLKFVENIEV VKKIILRKEK EVIKIIATHP 100
    QKVPKLRKIK ECEIVKEIYE HDIPFAKRYL IDNEIIPMTY WDFENKKPVS 150
    IEIPKLKSVA FDMEVYNRDT EPNPERDPIL MASFWDENGG KVITYKEFNH 200
    PNIEVVKNEK ELIKKIIETL KEYDVIYTYN GDNFDFPYLK ARAKIYGIDI 250
    NLGKDGEELK IKRGGMEYRS YIPGRVHIDL YPISRRLLKL TKYTLEDVVY 300
    NLFGIEKLKI PHTKIVDYWA NNDKTLIEYS LQDAKYTYKI GKYFFPLEVM 350
    FSRIVNQTPF EITRMSSGQM VEYLLMKRAF KENMIVPNKP DEEEYRRRVL 400
    TTYEGGYVKE PEKGMFEDII SMDFRCHPKG TKVVVKGKGI VNIEDVKEGN 450
    YVLGIDGWQK VKKVWKYEYE GELINVNGLK CTPNHKIPLR YKIKHKKINK 500
    NDYLVRDIYA KSLLTKFKGE GKLILCKDFE TIGNYEKYIN DMDEDFILKS 550
    ELIGILLAEG HLLRRDIEYF DSSRGKKRIS HQYRVEITVN EDEKDFIEKI 600
    KYIFKKLFNY ELYVRRKKGT KAITLGCAKK DIYLKIEEIL KNKEKYLPNA 650
    ILRGFFEGDG YVNTVRRAVV VNQGTNNYDK IKFIASLLDR LGIKYSFYTY 700
    SYEERGKKLK RYVIEIFSKG DLIKFSILIS FISRRKNNLL NEIIRQKTLY 750
    KIGDYGFYDL DDVCVSLESY KGEVYDLTLE GRPYYFANGI LTHNSLYPSI 800
    IISYNISPDT LDCECCKDVS EKILGHWFCK KKEGLIPKTL RNLIERRINI 850
    KRRMKKMAEI GEINEEYNLL DYEQKSLKIL ANSILPDEYL TIIEEDGIKV 900
    VKIGEYIDDL MRKHKDKIKF SGISEILETK NLKTFSFDKI TKKCEIKKVK 950
    ALIRHPYFGK AYKIKLRSGR TIKVTRGHSL FKYENGKIVE VKGDDVRFGD 1000
    LIVVPKKLTC VDKEVVINIP KRLINADEEE IKDLVITKHK DKAFFVKLKK 1050
    TLEDIENNKL KVIFDDCILY LKELGLIDYN IIKKINKVDI KILDEEKFKA 1100
    YKKYFDTVIE HGNFKKGRCN IQYIKIKDYI ANIPDKEFED CEIGAYSGKI 1150
    NALLKLDEKL AKFLGFFVTR GRLKKQKLKG ETVYEISVYK SLPEYQKEIA 1200
    ETFKEVFGAG SMVKDKVTMD NKIVYLVLKY IFKCGDKDKK HIPEELFLAS 1250
    ESVIKSFLDG FLKAKKNSHK GTSTFMAKDE KYLNQLMILF NLVGIPTRFT 1300
    PVKNKGYKLT LNPKYGTVKD LMLDEVKEIE AFEYSGYVYD LSVEDNENFL 1350
    VNNIYAHNSV YGYLAFPRAR FYSRECAEIV TYLGRKYILE TVKEAEKFGF 1400
    KVLYIDTDGF YAIWKEKISK EELIKKAMEF VEYINSKLPG TMELEFEGYF 1450
    KRGIFVTKKR YALIDENGRV TVKGLEFVRR DWSNIAKITQ RRVLEALLVE 1500
    GSIEKAKKII QDVIKDLREK KIKKEDLIIY TQLTKDPKEY KTTAPHVEIA 1550
    KKLMREGKRI KVGDIIGYII VKGTKSISER AKLPEEVDID DIDVNYYIDN 1600
    QILPPVLRIM EAVGVSKNEL KKEGAQLTLD KFFK 1634
    Length:1,634
    Mass (Da):191,710
    Last modified:December 15, 1998 - v2
    Checksum:i84A1FAFAB1F97DDD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98889.1.
    PIRiE64410.
    RefSeqiNP_247880.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB98889; AAB98889; MJ_0885.
    GeneIDi1451774.
    KEGGimja:MJ_0885.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98889.1 .
    PIRi E64410.
    RefSeqi NP_247880.1. NC_000909.1.

    3D structure databases

    ProteinModelPortali Q58295.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ0885.

    Protein family/group databases

    MEROPSi N10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB98889 ; AAB98889 ; MJ_0885 .
    GeneIDi 1451774.
    KEGGi mja:MJ_0885.

    Phylogenomic databases

    eggNOGi COG0417.
    KOi K02319.
    OMAi ERRINIK.

    Family and domain databases

    Gene3Di 2.170.16.10. 4 hits.
    3.10.28.10. 2 hits.
    3.30.420.10. 1 hit.
    InterProi IPR006172. DNA-dir_DNA_pol_B.
    IPR017964. DNA-dir_DNA_pol_B_CS.
    IPR006133. DNA-dir_DNA_pol_B_exonuc.
    IPR006134. DNA-dir_DNA_pol_B_multi_dom.
    IPR028992. Hedgehog/Intein_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR027434. Homing_endonucl.
    IPR006142. INTEIN.
    IPR004042. Intein_endonuc.
    IPR006141. Intein_splice_site.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    Pfami PF00136. DNA_pol_B. 3 hits.
    PF03104. DNA_pol_B_exo1. 1 hit.
    PF14528. LAGLIDADG_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00379. INTEIN.
    SMARTi SM00305. HintC. 2 hits.
    SM00306. HintN. 2 hits.
    SM00486. POLBc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51294. SSF51294. 4 hits.
    SSF53098. SSF53098. 1 hit.
    SSF55608. SSF55608. 2 hits.
    TIGRFAMsi TIGR01443. intein_Cterm. 2 hits.
    TIGR01445. intein_Nterm. 1 hit.
    PROSITEi PS00116. DNA_POLYMERASE_B. 1 hit.
    PS50818. INTEIN_C_TER. 2 hits.
    PS50819. INTEIN_ENDONUCLEASE. 2 hits.
    PS50817. INTEIN_N_TER. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

    Entry informationi

    Entry nameiDPOL_METJA
    AccessioniPrimary (citable) accession number: Q58295
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Intein-containing proteins
      List of intein-containing protein entries
    2. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3