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Q58295

- DPOL_METJA

UniProt

Q58295 - DPOL_METJA

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Protein
DNA polymerase
Gene
pol, MJ0885
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
  3. endonuclease activity Source: InterPro
  4. nucleotide binding Source: InterPro

GO - Biological processi

  1. intein-mediated protein splicing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Protein family/group databases

MEROPSiN10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase (EC:2.7.7.7)
Cleaved into the following 2 chains:
Gene namesi
Name:pol
Ordered Locus Names:MJ0885
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425DNA polymerase, 1st part Reviewed prediction
PRO_0000007317Add
BLAST
Chaini426 – 794369Mja pol-1 intein Reviewed prediction
PRO_0000007318Add
BLAST
Chaini795 – 88288DNA polymerase, 2nd part Reviewed prediction
PRO_0000007319Add
BLAST
Chaini883 – 1358476Mja pol-2 intein Reviewed prediction
PRO_0000007320Add
BLAST
Chaini1359 – 1634276DNA polymerase, 3rd part Reviewed prediction
PRO_0000007321Add
BLAST

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation Reviewed prediction.

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ0885.

Structurei

3D structure databases

ProteinModelPortaliQ58295.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini552 – 693142DOD-type homing endonuclease 1
Add
BLAST
Domaini1163 – 1295133DOD-type homing endonuclease 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0417.
KOiK02319.
OMAiERRINIK.

Family and domain databases

Gene3Di2.170.16.10. 4 hits.
3.10.28.10. 2 hits.
3.30.420.10. 1 hit.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR027434. Homing_endonucl.
IPR006142. INTEIN.
IPR004042. Intein_endonuc.
IPR006141. Intein_splice_site.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 3 hits.
PF03104. DNA_pol_B_exo1. 1 hit.
PF14528. LAGLIDADG_3. 1 hit.
[Graphical view]
PRINTSiPR00379. INTEIN.
SMARTiSM00305. HintC. 2 hits.
SM00306. HintN. 2 hits.
SM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF51294. SSF51294. 4 hits.
SSF53098. SSF53098. 1 hit.
SSF55608. SSF55608. 2 hits.
TIGRFAMsiTIGR01443. intein_Cterm. 2 hits.
TIGR01445. intein_Nterm. 1 hit.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
PS50818. INTEIN_C_TER. 2 hits.
PS50819. INTEIN_ENDONUCLEASE. 2 hits.
PS50817. INTEIN_N_TER. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q58295-1 [UniParc]FASTAAdd to Basket

« Hide

MGMSMGKIKI DALIDNTYKT IEDKAVIYLY LINSILKDRD FKPYFYVELH     50
KEKVENEDIE KIKEFLLKND LLKFVENIEV VKKIILRKEK EVIKIIATHP 100
QKVPKLRKIK ECEIVKEIYE HDIPFAKRYL IDNEIIPMTY WDFENKKPVS 150
IEIPKLKSVA FDMEVYNRDT EPNPERDPIL MASFWDENGG KVITYKEFNH 200
PNIEVVKNEK ELIKKIIETL KEYDVIYTYN GDNFDFPYLK ARAKIYGIDI 250
NLGKDGEELK IKRGGMEYRS YIPGRVHIDL YPISRRLLKL TKYTLEDVVY 300
NLFGIEKLKI PHTKIVDYWA NNDKTLIEYS LQDAKYTYKI GKYFFPLEVM 350
FSRIVNQTPF EITRMSSGQM VEYLLMKRAF KENMIVPNKP DEEEYRRRVL 400
TTYEGGYVKE PEKGMFEDII SMDFRCHPKG TKVVVKGKGI VNIEDVKEGN 450
YVLGIDGWQK VKKVWKYEYE GELINVNGLK CTPNHKIPLR YKIKHKKINK 500
NDYLVRDIYA KSLLTKFKGE GKLILCKDFE TIGNYEKYIN DMDEDFILKS 550
ELIGILLAEG HLLRRDIEYF DSSRGKKRIS HQYRVEITVN EDEKDFIEKI 600
KYIFKKLFNY ELYVRRKKGT KAITLGCAKK DIYLKIEEIL KNKEKYLPNA 650
ILRGFFEGDG YVNTVRRAVV VNQGTNNYDK IKFIASLLDR LGIKYSFYTY 700
SYEERGKKLK RYVIEIFSKG DLIKFSILIS FISRRKNNLL NEIIRQKTLY 750
KIGDYGFYDL DDVCVSLESY KGEVYDLTLE GRPYYFANGI LTHNSLYPSI 800
IISYNISPDT LDCECCKDVS EKILGHWFCK KKEGLIPKTL RNLIERRINI 850
KRRMKKMAEI GEINEEYNLL DYEQKSLKIL ANSILPDEYL TIIEEDGIKV 900
VKIGEYIDDL MRKHKDKIKF SGISEILETK NLKTFSFDKI TKKCEIKKVK 950
ALIRHPYFGK AYKIKLRSGR TIKVTRGHSL FKYENGKIVE VKGDDVRFGD 1000
LIVVPKKLTC VDKEVVINIP KRLINADEEE IKDLVITKHK DKAFFVKLKK 1050
TLEDIENNKL KVIFDDCILY LKELGLIDYN IIKKINKVDI KILDEEKFKA 1100
YKKYFDTVIE HGNFKKGRCN IQYIKIKDYI ANIPDKEFED CEIGAYSGKI 1150
NALLKLDEKL AKFLGFFVTR GRLKKQKLKG ETVYEISVYK SLPEYQKEIA 1200
ETFKEVFGAG SMVKDKVTMD NKIVYLVLKY IFKCGDKDKK HIPEELFLAS 1250
ESVIKSFLDG FLKAKKNSHK GTSTFMAKDE KYLNQLMILF NLVGIPTRFT 1300
PVKNKGYKLT LNPKYGTVKD LMLDEVKEIE AFEYSGYVYD LSVEDNENFL 1350
VNNIYAHNSV YGYLAFPRAR FYSRECAEIV TYLGRKYILE TVKEAEKFGF 1400
KVLYIDTDGF YAIWKEKISK EELIKKAMEF VEYINSKLPG TMELEFEGYF 1450
KRGIFVTKKR YALIDENGRV TVKGLEFVRR DWSNIAKITQ RRVLEALLVE 1500
GSIEKAKKII QDVIKDLREK KIKKEDLIIY TQLTKDPKEY KTTAPHVEIA 1550
KKLMREGKRI KVGDIIGYII VKGTKSISER AKLPEEVDID DIDVNYYIDN 1600
QILPPVLRIM EAVGVSKNEL KKEGAQLTLD KFFK 1634
Length:1,634
Mass (Da):191,710
Last modified:December 15, 1998 - v2
Checksum:i84A1FAFAB1F97DDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98889.1.
PIRiE64410.
RefSeqiNP_247880.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98889; AAB98889; MJ_0885.
GeneIDi1451774.
KEGGimja:MJ_0885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98889.1 .
PIRi E64410.
RefSeqi NP_247880.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58295.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0885.

Protein family/group databases

MEROPSi N10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98889 ; AAB98889 ; MJ_0885 .
GeneIDi 1451774.
KEGGi mja:MJ_0885.

Phylogenomic databases

eggNOGi COG0417.
KOi K02319.
OMAi ERRINIK.

Family and domain databases

Gene3Di 2.170.16.10. 4 hits.
3.10.28.10. 2 hits.
3.30.420.10. 1 hit.
InterProi IPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR027434. Homing_endonucl.
IPR006142. INTEIN.
IPR004042. Intein_endonuc.
IPR006141. Intein_splice_site.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF00136. DNA_pol_B. 3 hits.
PF03104. DNA_pol_B_exo1. 1 hit.
PF14528. LAGLIDADG_3. 1 hit.
[Graphical view ]
PRINTSi PR00379. INTEIN.
SMARTi SM00305. HintC. 2 hits.
SM00306. HintN. 2 hits.
SM00486. POLBc. 1 hit.
[Graphical view ]
SUPFAMi SSF51294. SSF51294. 4 hits.
SSF53098. SSF53098. 1 hit.
SSF55608. SSF55608. 2 hits.
TIGRFAMsi TIGR01443. intein_Cterm. 2 hits.
TIGR01445. intein_Nterm. 1 hit.
PROSITEi PS00116. DNA_POLYMERASE_B. 1 hit.
PS50818. INTEIN_C_TER. 2 hits.
PS50819. INTEIN_ENDONUCLEASE. 2 hits.
PS50817. INTEIN_N_TER. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiDPOL_METJA
AccessioniPrimary (citable) accession number: Q58295
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: September 3, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Intein-containing proteins
    List of intein-containing protein entries
  2. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3