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Protein

Probable S-adenosylmethionine-dependent methyltransferase MJ0882

Gene

MJ0882

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable methyltransferase that uses S-adenosylmethionine as the methyl donor. Binds neither NAD nor NADP in vitro.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841S-adenosyl-L-methionineCurated
Binding sitei129 – 1291S-adenosyl-L-methionineCurated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable S-adenosylmethionine-dependent methyltransferase MJ0882 (EC:2.1.1.-)
Gene namesi
Ordered Locus Names:MJ0882
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Probable S-adenosylmethionine-dependent methyltransferase MJ0882PRO_0000157176Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0882.

Structurei

Secondary structure

1
197
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi14 – 218Combined sources
Beta strandi24 – 318Combined sources
Turni35 – 384Combined sources
Helixi42 – 509Combined sources
Beta strandi58 – 625Combined sources
Helixi68 – 736Combined sources
Helixi74 – 763Combined sources
Beta strandi77 – 859Combined sources
Helixi87 – 9913Combined sources
Beta strandi107 – 1115Combined sources
Turni114 – 1174Combined sources
Beta strandi123 – 1286Combined sources
Helixi136 – 14914Combined sources
Beta strandi150 – 16213Combined sources
Helixi164 – 17714Combined sources
Beta strandi181 – 1866Combined sources
Beta strandi189 – 1957Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DUSX-ray1.80A4-197[»]
ProteinModelPortaliQ58292.
SMRiQ58292. Positions 4-197.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58292.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 675S-adenosyl-L-methionine bindingCurated
Regioni129 – 1324Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Phylogenomic databases

eggNOGiarCOG00110. Archaea.
COG2813. LUCA.
InParanoidiQ58292.
OMAiITNPPIR.
PhylomeDBiQ58292.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58292-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHYFSEKPTT KSDVKIVEDI LRGKKLKFKT DSGVFSYGKV DKGTKILVEN
60 70 80 90 100
VVVDKDDDIL DLGCGYGVIG IALADEVKST TMADINRRAI KLAKENIKLN
110 120 130 140 150
NLDNYDIRVV HSDLYENVKD RKYNKIITNP PIRAGKEVLH RIIEEGKELL
160 170 180 190
KDNGEIWVVI QTKQGAKSLA KYMKDVFGNV ETVTIKGGYR VLKSKKL
Length:197
Mass (Da):22,244
Last modified:November 1, 1996 - v1
Checksum:iF4E108E500ABEB28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98886.1.
PIRiB64410.

Genome annotation databases

EnsemblBacteriaiAAB98886; AAB98886; MJ_0882.
KEGGimja:MJ_0882.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98886.1.
PIRiB64410.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DUSX-ray1.80A4-197[»]
ProteinModelPortaliQ58292.
SMRiQ58292. Positions 4-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_0882.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98886; AAB98886; MJ_0882.
KEGGimja:MJ_0882.

Phylogenomic databases

eggNOGiarCOG00110. Archaea.
COG2813. LUCA.
InParanoidiQ58292.
OMAiITNPPIR.
PhylomeDBiQ58292.

Miscellaneous databases

EvolutionaryTraceiQ58292.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. "Structure-based experimental confirmation of biochemical function to a methyltransferase, MJ0882, from hyperthermophile Methanococcus jannaschii."
    Huang L., Hung L., Odell M., Yokota H., Kim R., Kim S.H.
    J. Struct. Funct. Genomics 2:121-127(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 4-197, S-ADENOSYLMETHIONINE BINDING.

Entry informationi

Entry nameiY882_METJA
AccessioniPrimary (citable) accession number: Q58292
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.