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Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99Carbamoyl phosphateUniRule annotation1
Binding sitei157OrnithineUniRule annotation1
Binding sitei222OrnithineUniRule annotation1
Binding sitei290Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciMJAN243232:G1GKE-955-MONOMER
UniPathwayiUPA00068; UER00112

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:argF
Ordered Locus Names:MJ0881
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001130651 – 305Ornithine carbamoyltransferaseAdd BLAST305

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0881

Structurei

3D structure databases

ProteinModelPortaliQ58291
SMRiQ58291
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 51Carbamoyl phosphate bindingUniRule annotation4
Regioni126 – 129Carbamoyl phosphate bindingUniRule annotation4
Regioni226 – 227Ornithine bindingUniRule annotation2
Regioni262 – 263Carbamoyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGiarCOG00912 Archaea
COG0078 LUCA
InParanoidiQ58291
KOiK00611
OMAiDGNNVCN
OrthoDBiPOG093Z05BF
PhylomeDBiQ58291

Family and domain databases

Gene3Di3.40.50.1370, 2 hits
HAMAPiMF_01109 OTCase, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR002292 Orn/put_carbamltrans
IPR024904 OTCase_ArgI
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00102 OTCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00658 orni_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q58291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLLDLDVLS REDVLKIIEY GIYFKKNRRK HEKILEGKSV AILFEKPSTR
60 70 80 90 100
TRMSFDIAVY ELGGHPLIMN QNEIHLGKKE SIKDTAKVMG RYVDTIVARV
110 120 130 140 150
YKHRHLEEMA KYSSVPVINA LSDLAHPCQI LADLMTIKEY KGKFKGLKIA
160 170 180 190 200
YLGDGNNVCN SLILGSALVG MDTYVGTPKG YEPNAKVVLK AKEIINNYGE
210 220 230 240 250
GSLTLTNDPI EAAEDADVLY TDVWISMGDD KDKEEVLKIF PPFQINSKLL
260 270 280 290 300
EYAKDDVIVM HCLPANRGYE ITDDVIDGEH SVVYDEAENR LHVQKGVFKF

IFERK
Length:305
Mass (Da):34,569
Last modified:November 1, 1996 - v1
Checksum:i98F12CBA15BB319A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB98885.1
PIRiA64410
RefSeqiWP_010870395.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB98885; AAB98885; MJ_0881
GeneIDi1451770
KEGGimja:MJ_0881

Similar proteinsi

Entry informationi

Entry nameiOTC_METJA
AccessioniPrimary (citable) accession number: Q58291
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health