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Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99Carbamoyl phosphateUniRule annotation1
Binding sitei157OrnithineUniRule annotation1
Binding sitei222OrnithineUniRule annotation1
Binding sitei290Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:argF
Ordered Locus Names:MJ0881
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001130651 – 305Ornithine carbamoyltransferaseAdd BLAST305

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0881.

Structurei

3D structure databases

ProteinModelPortaliQ58291.
SMRiQ58291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 51Carbamoyl phosphate bindingUniRule annotation4
Regioni126 – 129Carbamoyl phosphate bindingUniRule annotation4
Regioni226 – 227Ornithine bindingUniRule annotation2
Regioni262 – 263Carbamoyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGiarCOG00912. Archaea.
COG0078. LUCA.
InParanoidiQ58291.
KOiK00611.
OMAiHPMFLGK.
OrthoDBiPOG093Z05BF.
PhylomeDBiQ58291.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase. 1 hit.
InterProiView protein in InterPro
IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
PfamiView protein in Pfam
PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiView protein in PROSITE
PS00097. CARBAMOYLTRANSFERASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLLDLDVLS REDVLKIIEY GIYFKKNRRK HEKILEGKSV AILFEKPSTR
60 70 80 90 100
TRMSFDIAVY ELGGHPLIMN QNEIHLGKKE SIKDTAKVMG RYVDTIVARV
110 120 130 140 150
YKHRHLEEMA KYSSVPVINA LSDLAHPCQI LADLMTIKEY KGKFKGLKIA
160 170 180 190 200
YLGDGNNVCN SLILGSALVG MDTYVGTPKG YEPNAKVVLK AKEIINNYGE
210 220 230 240 250
GSLTLTNDPI EAAEDADVLY TDVWISMGDD KDKEEVLKIF PPFQINSKLL
260 270 280 290 300
EYAKDDVIVM HCLPANRGYE ITDDVIDGEH SVVYDEAENR LHVQKGVFKF

IFERK
Length:305
Mass (Da):34,569
Last modified:November 1, 1996 - v1
Checksum:i98F12CBA15BB319A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98885.1.
PIRiA64410.
RefSeqiWP_010870395.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98885; AAB98885; MJ_0881.
GeneIDi1451770.
KEGGimja:MJ_0881.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiOTC_METJA
AccessioniPrimary (citable) accession number: Q58291
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families