Q58273 (HDRB2_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CoB--CoM heterodisulfide reductase subunit B 2
EC=1.8.98.1

Gene names

Name:	hdrB2
Ordered Locus Names:	MJ0863

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrB may have a function in energy transduction By similarity.
Catalytic activity	Coenzyme B + coenzyme M + methanophenazine = N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L-threonine + dihydromethanophenazine.
Pathway	Cofactor metabolism; coenzyme M-coenzyme B heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1.
Subunit structure	The heterodisulfide reductase is composed of three subunits; hdrA, hdrB and hdrC By similarity.
Sequence similarities	Belongs to the hdrB family.

Ontologies

Keywords
Biological process	Methanogenesis
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cofactor metabolic process Inferred from electronic annotation. Source: InterPro methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	CoB--CoM heterodisulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	CoB--CoM heterodisulfide reductase subunit B 2		PRO_0000150066

Sequences

	Sequence		Length	Mass (Da)
	Q58273 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 35A2A278491E8ED0	FASTA	295	32,789
	10 20 30 40 50 60 MKYAFFLGCI MPHRYPGVEK ATKIVMEELG VELEYMPGAS CCPAPGVFGS FDQKTWLTLA 70 80 90 100 110 120 ARNLCIAEEM GLDIVTVCNG CYGSLFEAAH ILHENKEALD FVNEKLDKIG KQYKGTIKVR 130 140 150 160 170 180 HFAELIYKDI GVDKIKEKVV KPLDVLNVAI HYGCHFLKPS DVKHLDSPER PKLLEEIVAA 190 200 210 220 230 240 TGAKPVMYRD YLMCCGAGGG VRARFLPTAL DMTKEKIRNM LEAGADCTVN VCPFCHLQFD 250 260 270 280 290 RGQVEIKEKF GEEYKLPVLH LSQLLGLAFG MKPEDLAVSV HAIPVDPVLK KLGIE

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98868.1.
PIR	G64407.
RefSeq	NP_247858.1. NC_000909.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1451752.
GenomeReviews	Gene locus MJ0863 in contig L77117_GR.
KEGG	mja:MJ_0863.
NMPDR	fig|243232.1.peg.895.
TIGR	MJ0863.
Phylogenomic databases
HOGENOM	HBG513215.
OMA	HYGCHFL.
ProtClustDB	CLSK876313.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_0863-MONOMER.
Family and domain databases
InterPro	IPR017678. CoB/CoM_hetero-S_Rdtase_bsu. IPR004017. Cys_rich_dom. [Graphical view]
KO	K03389.
Pfam	PF02754. CCG. 2 hits. [Graphical view]
TIGRFAMs	TIGR03288. CoB_CoM_SS_B. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HDRB2_METJA

Accession

Primary (citable) accession number: Q58273

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program